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Why does grapefruit juice help

GF juice makes a differance inb the length of the roll usually. make sure you drink fresh or a very high juice concentrate percentage with no sugar added about 30 mins before rolling on an empty stomach aswell.

as for hydrogen peroxide, the jury is still out. the body actually produces h202 and uses it to defend against bacteria and fungus.

if you ever had a cough and/or a nasty head cold and rolled, did u ever wonder why the next morning you would be fine. and if you took care of yourself the symptoms wouldnt come back?

maybe its the h202 and the body temp rise, maybe not...

:-)
 
JimiHawK* said:
grapefruit juice inhibits CYP3A4 enzyme. Im not sure if MDMA is broken down by that enzyme or not. if it is - then yes you will get more effects from a dose. if not - then the added vitamins etc sure wouldnt hurt.


ive only ever used grapefruit juice to potentiate codeine - and the effects are small but noted.
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Wrong way round bud.
Not inhibit. Induce.
The CYP3A4 enzyme is what demethylates codeine to morphine. If you inhibited it, you'd be reducing it's activity, noit increasing it - not what we want to do!

And no, grapefruit juice will not help your roll. Wrong enzyme.
The antioxidants are all good though!
 
MattPsy said:
Wrong way round bud.
Not inhibit. Induce.
The CYP3A4 enzyme is what demethylates codeine to morphine. If you inhibited it, you'd be reducing it's activity, noit increasing it - not what we want to do!

And no, grapefruit juice will not help your roll. Wrong enzyme.
The antioxidants are all good though!
Click to expand...

I think he was right actually. i know cause they have been using this in supplements to increased effectiveness.

check out
http://en.wikipedia.org/wiki/Naringin
see also
cautions

if it affects caffeine which is a cns stimulant it probably does the same with e and amp etc

also the effects are cumulative. so one glass a day for a week will yield better results. but be carefull. everybody is different.
 
nocturnal_euphoria said:
when the seretonin in your body begins to depleat (rolling nasty ass balls) your seretonin receiver thingies start to take in dopamine instead of seretonin which is okay for the receiver things because it doesnt know the diffrence, but its really bad for your synapsis because the dopamine breaks down and oxidizes into hydrogen-peroxide...BAD!! hydrogen-peroxide is a neurotoxin and will slowly destroy your synapsis....so the vitamin-c (an anti-oxidant) does just that...helps prevent the oxidation of the dopamine to further prevent the production of hydrogen-peroxide...not bad for a 17 year old heh%)
Click to expand...
not bad for a 17 year old, but that theory is outdated bro=D
 
Back to the basic "What can enhance my roll?" question

People have said alot of things like,
Vitamin C (no)
Grapefruit Juice (no)
Vitamin B12 (no)
Not being exposed to the sunlight (no)
Having a good setting (no, just makes you have the best roll the pill can preduce. Not a higher one)
^^^^^ And thats what the real question we want to know the answer too. What can we do to make the effect of one pill seem like two?

Answer: I say we just keep drinking stuff and poppin random stuff untill we find whatever enhances our roll.
(And as soon as we find one, please for the love of God, POST IT!)
P.L.U.R.
 
A good idea would be to drink a glass of oj when you first start to roll because of the antioxidant effects,ect... Then take an ssri (such as Lexapro 10 mg because most people tolerate this drug) about 6 -8 hours into the roll to prevent the dopamine from breaking down into hydrogen peroxide.
 
^
Outdated theory (regarding the SSRI) I believe. AFAIK, you'd have to take it before rolling (which would weaken the roll).
 
MazDan said:
Thanks frizz, added to the Directory under Grapefruit Juice.
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cool.. though i saw u said thanks to C22.. I wrote the FAQ, C22 just posted it in the FAQ forum ;)


and if the SSRI theory is outdated u might want to take the 'This is your brain on Ecstacy' link off the top of the recommended reading at the top of the directory since thats where I suspect most people 1st hear about the theory.. :) surprised to hear it's no longer thought to be true cause i used to swear by prozac.. i would even keep a stop watch going during my rolls so i could make sure to take it at the right time lol
 
I think the jury's still out on the mechanism of MDMA-induced neurotoxicity. Certainly the Nichols/Sprague theory has fallen out of favor, but it hasn't been disproven AFAIK.
 
MattPsy said:
Wrong way round bud.
Not inhibit. Induce.
The CYP3A4 enzyme is what demethylates codeine to morphine. If you inhibited it, you'd be reducing it's activity, noit increasing it - not what we want to do!

And no, grapefruit juice will not help your roll. Wrong enzyme.
The antioxidants are all good though!
Click to expand...

No CYP34A is the enzyme that breaks opiates down to be expelled from the body. CYP2D6 is the enzyme that converts codeine to morphine, Hydrocodone to hydromorphone, etc. This is the tricky part. You want to inhibit CYP3A4 without inhibiting CYP2D6.

This article talks a little about the two different enzymes:

http://en.wikipedia.org/wiki/Codeine

This link talks about the inhibitors and inducers for both enzymes:

[removed at request of source]
 
Last edited by a moderator:
5-HT2 said:
I think the jury's still out on the mechanism of MDMA-induced neurotoxicity. Certainly the Nichols/Sprague theory has fallen out of favor, but it hasn't been disproven AFAIK.
Click to expand...

I was just going off TheDEA.org's site, where he says that post-MDMA administration of SSRI's is ineffective in preventing neurotoxicity (though taking an SSRI before MDMA might work). Not saying that the whole neurotoxicity model is wrong :) (I'm in no way qualified to argue one way or the other...)
 
MattPsy said:
Wrong way round bud.
Not inhibit. Induce.
The CYP3A4 enzyme is what demethylates codeine to morphine. If you inhibited it, you'd be reducing it's activity, noit increasing it - not what we want to do!

And no, grapefruit juice will not help your roll. Wrong enzyme.
The antioxidants are all good though!
Click to expand...


I'll use wikipedia for simplicity/accessibility

Wikipedia said:
Grapefruit juice, and grapefruit in general, is a potent inhibitor of the Cytochrome_P450 enzyme CYP3A4
Click to expand...

http://en.wikipedia.org/wiki/Grapefruit_juice

Wikipedia said:
The conversion of codeine to morphine occurs in the liver and is catalysed by the cytochrome P450 enzyme CYP2D6. CYP3A4 produces norcodeine
Click to expand...

http://en.wikipedia.org/wiki/Codeine




1. drink grapefruit juice 1hr before codeine
2. take your codeine
3. ???
4. PROFIT!


%)
 
Ginger Jack said:
People have said alot of things like,
Vitamin C (no)
Grapefruit Juice (no)
Vitamin B12 (no)
Not being exposed to the sunlight (no)
Having a good setting (no, just makes you have the best roll the pill can preduce. Not a higher one)
^^^^^ And thats what the real question we want to know the answer too. What can we do to make the effect of one pill seem like two?

Answer: I say we just keep drinking stuff and poppin random stuff untill we find whatever enhances our roll.
(And as soon as we find one, please for the love of God, POST IT!)
P.L.U.R.
Click to expand...

Just a small techinicality. There was a study done on giving rats very high doses of Vitamin C I.P. along with MDMA and it blocked the tolerance to Serotonin release if I remember correctly. So it won't potentiate this roll, but maybe the next?
 
tonaros said:
Not everything that makes your roll better is better for your body.. I'm talking about L-Tyrosine specifically, but anyone interested in improving a roll and decreasing neurotoxicity should read this:

http://www.rollinballzcrew.com/preload.shtml
Click to expand...

Some of the info on that site seems screwy. For instance it says Vitamin B-6 + L-Tryptophan = Serotonin, but as far as I know B6 works with 5-htp which comes after L-Tryptophan and the stop from L-Tryp to 5-HTP is the rate limiting part of the reaction so adding B6 won't help at all.

It also says Grapefruit juice will help potentiate MDMA and we've already been through it, and it will not to any appreciable degree.
 
Broshious said:
Just a small techinicality. There was a study done on giving rats very high doses of Vitamin C I.P. along with MDMA and it blocked the tolerance to Serotonin release if I remember correctly. So it won't potentiate this roll, but maybe the next?
Click to expand...
Ya, your right. The neeeext roll. But everyones trying to find out what they can take to potentiate the present roll.
But I know what you mean.
 
Ginger Jack said:
Ya, your right. The neeeext roll. But everyones trying to find out what they can take to potentiate the present roll.
But I know what you mean.
Click to expand...

One person had good results using Tianeptine. Problem is that it's not available in the US and is quite expensive.

Inositol is said to increase the sensitivity of 5HT2A receptors so taking that for awhile before rolling MIGHT help SOMEWHAT. Not sure if it affects any other receptors.
 
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