Meanwhile, Johnson & Johnson, corporate owners of Tylenol since the fifties, struck twice: not just with the "headache wars" of the 80's (like the Cola Wars, I still get flashes of PTSD). Compared to Aspirin and Motrin (ibuprofen), Tylenol (paracetemol/acetaminophen) was the shortest-lasting, least effective and most toxic (and still is), but what does data matter when you got good commercials? Yes, it would turn out paying off the FDA helps too.
So when there was a tall enough mountain of evidence for liver damage due to Tylenol, the FDA finally had to say, "excuse us, sirs, we need you, uh, to at least put a warning on it that you shouldn't take Tylenol if you drink alcohol." Johnson & Johnson said Fuck That Noise, and wrote a compromise on another check to the FDA, such that
some booze is ok, a vague 2-3 drinks per day (a lot of booze) and that ALL painkillers on the market everywhere must ALSO carry the same warning. Not to start that thread again, but you can drink alcohol and use aspirin and ibuprofen without worrying about your liver. (Might be bad for stomach bleeding with Aspirin and Aleve though.)
This story has been going on for over forty years and only recently has the FDA decided to try at least reducing the amount of unnecessary toxic chemical in like all the products in WalGreen's. It's only in there to make it harder to get rid of anyway. Tylenol PM is really just Benadryl people, with half your daily max of Tylenol. For no reason, other than to keep Tylenol that much more insidious in the face of recall. It's probably in the Flint drinking water too.
forever changes said:
Apparently there's a drug called Glutethimide which induces the CYP2D6 enzyme.
Yeah, you can stop at "hypnotic sedative." Not OTC. There are hardly any inducers of CYP2D6, and of the ones available, none are worth taking just to get a codeine buzz.