I am a bit confused as to why this is. I would think SSRI's would have the exact opposite effect and increase the effects. It is my understanding that SSRI's prevent serotonin from being reuptaked, leaving more serotonin in your brain. Therefore, since MDMA releases serotonin, wouldn't being on SSRI's leave more of that serotonin flooding throughout your brain? I think of it like this... MDMA releases serotonin, SSRI's prevent the serotonin from being reuptaken, so more serotonin in your brain, right? Wouldn't more serotonin = more euphoria? I don't get it...
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MDMA &
Empathogenic
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Why do SSRI's prevent rolling?
- Thread starter Tromps
- Start date
SSRIS have a greater affinity for the reuptake trasnporter than MDMA and serotonin both.Ecstasy cannot get into the serotonin axon terminal in order to release the serotonin.
P - antidepressant
red - serotonin
blue - dopamine
Yellow - reuptake transporter
Hammer - MAIOs
E - MDMA
P - antidepressant
red - serotonin
blue - dopamine
Yellow - reuptake transporter
Hammer - MAIOs
E - MDMA
Last edited:
C8H10N4O2
Bluelighter
- Joined
- Jan 4, 2010
- Messages
- 448
MDxx is an SSRE. It enhances the reuptake of serotonin, which causes you to use and reuse a large amount of neurotransmitters in a short period of time. As the effects wear off, your brain is left with less serotonin, because the neurotransmitters deteriorate from overuse and so many have been used that your brain is depleted.
An SSRI is meant to inhibit the exact process MDxx is trying to carry out. It leaves serotonin where it can act upon a postsynaptic neuron for longer, before the presynaptic neuron reabsorbs it. As stated above, SSRIs have a greater affinity for the transporter than MDxx, so an SSRI medication will prevent MDxx from working at all.
By the way, reuptake does not remove serotonin from your brain. It is just moving back to the original neuron that released it. While it is sitting in a presynaptic neuron, it isn't active. Only when it is released into the axon terminal during a nerve impulse, do you get the effects.
An SSRI is meant to inhibit the exact process MDxx is trying to carry out. It leaves serotonin where it can act upon a postsynaptic neuron for longer, before the presynaptic neuron reabsorbs it. As stated above, SSRIs have a greater affinity for the transporter than MDxx, so an SSRI medication will prevent MDxx from working at all.
By the way, reuptake does not remove serotonin from your brain. It is just moving back to the original neuron that released it. While it is sitting in a presynaptic neuron, it isn't active. Only when it is released into the axon terminal during a nerve impulse, do you get the effects.