Neuroprotection
Bluelighter
- Joined
- Apr 18, 2015
- Messages
- 1,082
Nitric oxide is an important gassius neurotransmitter and neuromodulater, as well as one of the main down stream affectors of NMDAr activation. Its also a key free radical implicated in neurodegeneration and neuropathology, particularly psychitsaphrenia and depression. The NOS1 enzyme generates nitric oxide in neurons in response to calcium imflux into the cell through NMDA channels.
Spesific NOS1 inhibitors including 7 Nitroindizole and methylene blue have been shown to have various benefits I will list below:
Block or reduce excitotoxicity of glutamate and other toxic aminoacids, both exogenous and endogenous.
Prevent opioid withdrawls in anmils and cultured human neuronal cells, as well as block tolerance development to opioids and even reverce it. Also NOS1 inhibition possibley reverces long term adaptations that often leave former addicts at risk of relaps.
Greatly reduce methamphetamine and other stimulants neurotoxicity and prevents/reverses tolerance.
Have potent anxiolytic and antipsychotic affects without typical side affects seen with benzodiazepines and dopamine antagonists.
Drastically reduce benzodiazepine withdrawl symptoms, block seizures associated with withdrawal as well as epilepsy, and over time eliminates tolerance to benzodiazepines and all other gabaAergics. NOS1 inhibitors also reduce propofol and other anaesthetic requirement to produce deap unconsciousness.
Have powerfull antidepressant affects.
Are potent neuroprotective agents in animals.
Given all these benefits, why an’t potent NOS1 inhibitors particularly 7 nitroindizole used in humans. Are there any sideaffects or obstacles prevent drug development
Spesific NOS1 inhibitors including 7 Nitroindizole and methylene blue have been shown to have various benefits I will list below:
Block or reduce excitotoxicity of glutamate and other toxic aminoacids, both exogenous and endogenous.
Prevent opioid withdrawls in anmils and cultured human neuronal cells, as well as block tolerance development to opioids and even reverce it. Also NOS1 inhibition possibley reverces long term adaptations that often leave former addicts at risk of relaps.
Greatly reduce methamphetamine and other stimulants neurotoxicity and prevents/reverses tolerance.
Have potent anxiolytic and antipsychotic affects without typical side affects seen with benzodiazepines and dopamine antagonists.
Drastically reduce benzodiazepine withdrawl symptoms, block seizures associated with withdrawal as well as epilepsy, and over time eliminates tolerance to benzodiazepines and all other gabaAergics. NOS1 inhibitors also reduce propofol and other anaesthetic requirement to produce deap unconsciousness.
Have powerfull antidepressant affects.
Are potent neuroprotective agents in animals.
Given all these benefits, why an’t potent NOS1 inhibitors particularly 7 nitroindizole used in humans. Are there any sideaffects or obstacles prevent drug development