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Opioids why are benzos most commonly used to potentate opioids?

I'm guessing because of the additive sedative effect....? What does the OP use to potentiate opioids? Note: benzodiazepines do not POTENTIATE opiates, they merely add CNS depression via their own mechanisms on the GABA calcium channels, having no interaction whatsoever with the opioid receptors or metabolism, so it's not a true potentiator compared to something like Grapefruit Juice, which inhibits liver enzymes (P450) and in doing so, slow the rate of metabolism of the opioids, lengthening or strengthening the intensity / duration of the experience. Benzos don't potentiate opioids, they have what is called a "SYNERGISTIC" or more commonly, additive effect, because it's two drugs both causing CNS depression but not by interacting with eachother to produce the added sedation internally.

What's the HR value of this thread..?
 
Yeah, and getting a tagamet script to potentiate both is really easy (it's not on the shelves anymore here since a long time, prolly cause of the many many interactions), but those 600mg horsepills are very welcome for me as I have tolerance to both).
 
THE_REAL_OBLIVION said:
Yeah, and getting a tagamet script to potentiate both is really easy (it's not on the shelves anymore here since a long time, prolly cause of the many many interactions), but those 600mg horsepills are very welcome for me as I have tolerance to both).
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Really? Why'd they take Cimetidine off the shelves? You can still get it here but I never felt it did anything at all.
 
tricomb said:
Really? Why'd they take Cimetidine off the shelves? You can still get it here but I never felt it did anything at all.
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Yeah it's rx only because it causes too many interactions a pharmacist told me, I vaguely remember it being on the shelves though, Tagamet-HB, white and orange box. Can only get it through a script which is good because it allows for high dosage pills. I asked for the 600mg ones, not pushing my luck by asking for the 800's and it was easy to get. Maybe you weren't using enough. I definitely felt crushed kadian beads turned into IR morphine powder which i'd pre-boost with 1200mg of tagamet, wouldn't last nowhere as long without it.
 
They do not go together and especially they are not to be taken together. There is a difference to search for a nod which is more like going to sleep compared to seeking euphoria which is what provides a good feeling.

Increasing GABA is in some ways the opposite of increasing dopamine. We have natural opioid receptors that create dopamine in small amounts that we can't notice every day. Naturally we are led to do things that activate dopamine through those receptors, which is referred to as an action and reward process of thinking. The Mu receptors are the specific receptors that cause the positive drive, well being, and energy. They were named after the poppy plant ('Opioid' and 'Morphine' for 'Mu') because it was with substances derived from the poppy plant that the scientists were able to experiment and single out these receptors, concluding that the 'Mu' receptors were the specific source of activity for dopamine (positive drive, well being, and energy). So it is a release of dopamine with anything, but with opiates it is a release of dopamine which signals absolutely correctly which the natural based chemicals and the specific part of the mind that receives them scientifically speaking.

So if you can picture the dopamine activity increasing between receptors when being released, an increase of GABA will slow down the activity between the receptors - not just with dopamine but with many other areas of the mind also. GABA literally slows down the signals between transmitters in our mind.
 
Rox said:
They do not go together and especially they are not to be taken together. There is a difference to search for a nod which is more like going to sleep compared to seeking euphoria which is what provides a good feeling.

Increasing GABA is in some ways the opposite of increasing dopamine. We have natural opioid receptors that create dopamine in small amounts that we can't notice every day. Naturally we are led to do things that activate dopamine through those receptors, which is referred to as an action and reward process of thinking. The Mu receptors are the specific receptors that cause the positive drive, well being, and energy. They were named after the poppy plant ('Opioid' and 'Morphine' for 'Mu') because it was with substances derived from the poppy plant that the scientists were able to experiment and single out these receptors, concluding that the 'Mu' receptors were the specific source of activity for dopamine (positive drive, well being, and energy). So it is a release of dopamine with anything, but with opiates it is a release of dopamine which signals absolutely correctly which the natural based chemicals and the specific part of the mind that receives them scientifically speaking.

So if you can picture the dopamine activity increasing between receptors when being released, an increase of GABA will slow down the activity between the receptors - not just with dopamine but with many other areas of the mind also. GABA literally slows down the signals between transmitters in our mind.
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Spoken like someone who only knows theory and zero practice. Although I do not wish a benzo habit on anybody, I have a script since forever so I was even allowed to be on Methadone AND diazepam at once since my benzo tolerance surpassed in length my opiate addiction by half a decade. Some people need to add nuance before making such "square" posts.
 
Dang, no lie: I was using opiates (and I'm not an opiate "user" .. I had a few Vicodins/mo for PCOS pain) to potentiate my little slivers of benzo before I ran out.

Maybe I did it backwards. I felt no pain; it sorta got me through. But the benzo was Xanax, which I've recently quit to try Klonipins (all Rx, but Xanax is just a freakin problem. Doc doesn't see why; see my other threads, he's stable on Ativan. I'd been stable on Ativan too, but Xanax is a different little beastie. Tastes nasty too.) I just can't with Xanax (and it's been, geez, almost 2 years this spring.) Hope this K works.
 
Personally, benzos+methadone is a very unique mixture. Obviously not safe, and I'm not recommending it. But there are a LOT of people that once they stop their heroin/opioid addiction/habit and start going to the Methadone Clinic for MMT, they want a new "downer" high to replace it. Strangely enough, my daily methadone dose alone does not provide a high or "feel", and the dose of benzo by itself doesn't make me particularly euphoric, but when I take a couple xanax with my morning methadone dose, it creates a synergistic effect that is like taking a different drug altogether and I have experienced extreme nodding from the combo. Obviously opioids and benzos fight to be metabolized often times by the same liver enzymes (CYP450, CYP3A4, CYP2D19, etc.) so it increases the amount of the drug in the system since it can't be metabolized at its normal rate, causing one or both drugs to have a stronger effect. Doctors often times refer to this as "rather than 1+1 equaling 2, by mixing benzo (1) and opioid (1), you end up with something like 1+1=3 or 1+1=4.

Personally, I like to take cimetidine 200mg tabs OTC with my benzos, as long as they're ones that are boosted by cimetidine, and it's very noticeable. I even used cimetidine to boost my methadone concentrations one day and it was such a boost that I ended up vomiting because it was so strong in my system apparently. Also, a bit of advice: cimetidine (Tagamet, Tagamet-HB) is expensive as HELL in drugstores like CVS, walgreens, Rite Aid, etc, including their store-brand generic Cimetidine 200mg tablet bottles. At my local CVS, their store branded cimetidine 200mg bottle of pills is like 60 tabs for about $12-15. However, at Walmart, a bottle of Cimetidine 200mg x 60 tablets is just under $5, a HUGE savings, and so far the only place I've found with them at this low of a price.

To answer the OP's thread title question directly: basically it's simple, a lot of opioid users love their downer and adding in another strong depressant (benzos) creates a very elevated high due to the high of the opioid, the high of the benzo, added to the potentiation factor, and you get a super high for the user. Whereas with cimetidine, it alone has no psychoactive effects so it would only add length to the opioid high or make it more intense by a bit.
 
Hiltoniano said:
Well I am one of the few who find benzos only increase sedation of opiates while actually reducing euphoria and the "high"
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CaptainKratom said:
Benzos have the power to ruin ANY opiate euphoria for me. The combo is only good if the benzo dose is low, otherwise I'm robbed of euphoria and left with a sleepy dull buzz.
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I have to agree with both of these posts....

Taking benzos in combination with opiates may "fuck you up" more, but I find that it actually takes away from the subtle nuances of the opiate high....that, and it's very dangerous and difficult to gauge!

The only circumstance that justifies mixing benzos with opiates IMO, is when one has an insufficient amount of opiates to either "keep well" or "feel it"...With a sufficient supply of opiates, there's no excuse to risk this notoriously dangerous combination of drugs!
 
^Agreedx3, taking benzos after opiates completely ruins the experience. They turn that warm and fuzzy feeling into a dull sedation. Unfortunately, every time I take a recreational dose of benzos I get a very strong craving for opiates.
 
Oh ROXIanne! said:
^Agreedx3, taking benzos after opiates completely ruins the experience. They turn that warm and fuzzy feeling into a dull sedation.
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Yea like seriously. hah a I know I posted about this on the first page. But the feelings that really make the blissful mindset that narcotics put you in ,soon as you take it the benzos smack you stupid and turn the switch off for higher thinking/ more subtle/complex feelings that include the opiate high and ends up being a sleep/knockout kinda high instead of buzzing super nice. nodding is not even increased i just sleep instead, annoying as hell.
 
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How about you were addicted to benzos from way way WAY before you needed methadone (i'm on bupe now but still...)I'm sure the fact I only went up to 60mg of methadone is due to me being allowed my mere 20mg of valium a day, which at first they tried to taper me from WAY TOO QUICK and had to have my psychiatrist intervene. I'd probably be dead from seizures if he didn't do anything, or I would have jumped off a bridge. Benzo withdrawal is worse than opi withdrawal. I just got on ORT last year because I had started to IV dillies. I was always able to stop eating oxys (CDN's, the real shit) and Supeudol 20mg footballs even if it was a difficult 3-4 days to endure. Impossible for me to endure not shooting up at least 12mg of dillies a day. But I guess if I really wanted to stop, I could have, unlike fucken benzos.
 
Rox said:
They do not go together and especially they are not to be taken together. There is a difference to search for a nod which is more like going to sleep compared to seeking euphoria which is what provides a good feeling.

Increasing GABA is in some ways the opposite of increasing dopamine. We have natural opioid receptors that create dopamine in small amounts that we can't notice every day. Naturally we are led to do things that activate dopamine through those receptors, which is referred to as an action and reward process of thinking. The Mu receptors are the specific receptors that cause the positive drive, well being, and energy. They were named after the poppy plant ('Opioid' and 'Morphine' for 'Mu') because it was with substances derived from the poppy plant that the scientists were able to experiment and single out these receptors, concluding that the 'Mu' receptors were the specific source of activity for dopamine (positive drive, well being, and energy). So it is a release of dopamine with anything, but with opiates it is a release of dopamine which signals absolutely correctly which the natural based chemicals and the specific part of the mind that receives them scientifically speaking.

So if you can picture the dopamine activity increasing between receptors when being released, an increase of GABA will slow down the activity between the receptors - not just with dopamine but with many other areas of the mind also. GABA literally slows down the signals between transmitters in our mind.
Click to expand...

When dealing with morphine (and therefore heroin) you need to factor in the effects of the active metabolite morphine-3-glucuronide. M3G which causes convulsant effects, as well as some other unpleasant effects. It is partially mediated through the GABA receptors, so a benzo can help ease some unpleasant effects in users of heroin or morphine
 
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