• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

Why Am I Unable To Get High?

J

jstn789

Greenlighter
Joined
May 11, 2008
Messages
24
I am not able to get high or feel euphoric. What causes this in people and is there any way that I may be able to combat this?

Is anyone else here unable to get high?
 
Pretty vague question fella, although I can probably take a stab at what you're asking about here. But, just to be sure, and to get the ball rolling...

- What substances have you tried, and did you test it for purity? What dosage did you take? Had you taken anything else with it/them, e.g. alcohol? Were you tired, e.g. lack of sleep, or ill, e.g. a cold?
- How heavy are you, and are you over/under weight? Do you have any medical condition(s), physical or psychological? Are you taking any medication?

Of course, no need to answer any of these unless you're comfortable doing so =o)

/al
 
1. It would help to have something to be happy about. Try acheiving something for once, something that will make you feel a little euphoric on it's own. Theirs lots of ways to get into that state of mind without drugs. Like falling in love, creating something, serving others, realizing a yearning...

2. Make sure you're getting good quality substances.

3. Excercise, proper nutrition, adequate rest

4. May be your neurochemistry or genetics. Maybe talk to your parents about their drug use.

i can probably think of a bunch of other possible reasons, but think about those first.
 
is this with all substances or are you just talking about tolerance?

if all, then either you are getting bunk products, not doing enough, or are anxious/depressed so that your idea of "high" is not reached. if your saying all products are having no effect then thats just, frankly, impossible.
could you be more specific?
 
Are you on medications and what drugs specifically are you talking about? Have you ever been high before is or is it something you've never achieved?
 
^ yea, mood stabilizers and antipsychotics, might prevent euphoria from drugs.
 
Catholicism, the Church of Jesus Christ of Latter Day Saints and Islam are other common predictors.
 
Well, I have tried weed, valium, morphine, ritalin, alcohol, percocet and oxys. I have pain sometimes, but whether I have pain or not..nothing works. Does that matter? I didn't think that would be important.

I don't think I would have a tolerance to any. I've gone 4 - 6 months without doing some and then I go back and try and I feel nothing.

I try not to mix drugs, but a couple times I took Oxy with Dex, but it did nothing. Oh, and I took Oxy with muscle relax. can't remember what they were called but someone told me that it feels great...nothing.

I'm not overweight, but I am depressed a lot, I guess. Does this help?
 
jstn789 said:
Well, I have tried weed, valium, morphine, ritalin, alcohol, percocet and oxys. I have pain sometimes, but whether I have pain or not..nothing works. Does that matter? I didn't think that would be important.

I don't think I would have a tolerance to any. I've gone 4 - 6 months without doing some and then I go back and try and I feel nothing.

I try not to mix drugs, but a couple times I took Oxy with Dex, but it did nothing. Oh, and I took Oxy with muscle relax. can't remember what they were called but someone told me that it feels great...nothing.

I'm not overweight, but I am depressed a lot, I guess. Does this help?
Click to expand...

Try GHB and or MDMA, on separate occasions, that might change something for you.
 
what have you tryed, and every1 should be able 2 get high, do you take meds?¿
 
DJ 303 said:
if all, then either you are getting bunk products, not doing enough, or are anxious/depressed so that your idea of "high" is not reached. if your saying all products are having no effect then thats just, frankly, impossible.
Click to expand...

:| The most perfunctory, slapdash meditation on the matter reveals nearly instantaneously that to be a laughable and obviously false conceit. Of course, it's possible. Not only is it possible; it's fairly common.

Anhedonia. There are many routes to anhedonia - depression, schizophrenia, bipolar disorder, Alzheimer's, excessive drug abuse (especially of amphetamines), stroke, head injury (possibly), etc...

I have been devoting what little energy remains to me to understanding the pathophysiology of anhedonia and devising ways to remedy the condition. But, alas!, I am ignorant beyond all measure, and so this undertaking of mine can aptly be likened to attempting to excavate a hole of the proportions of the grand canyon with a gardening trowel. I don't possess the necessary tools; and the fulfillment of my designs is a prerequisite to the acquisition of those tools! Oh, reality, you really are such a cruel, sadistic rascal. [insert bird-giving-hand emoticon here]

The best ideas I've been able to come up with are:

  • Long-term typical neuroleptic treatment
  • Long-term D2 agonist treatment
  • Long-term naltrexone/naloxone treatment
  • Long-term kappa-opioid receptor agonist treatment
  • Kappa-opioid receptor antagonists
  • Long-term SRI therapy
  • Phosphodiesterase 4 inhibitors
  • Soluble guanylyl cyclase antagonists
  • Nitric oxide synthase inhibitors
  • Phosphodiesterase 5 inducers (if there is such a thing)
  • Sigma receptor agonists (antagonists?)
  • Some kind of modulator of prolyl oligopeptidase activity.
  • Possibly glial cell line-derived neurotrophic factor injected into certain parts of the mesolimbic pathway.
  • Gene therapy

These all have tremendous drawbacks - particularly those which antagonize the D2 receptor and those which decrease cGMP levels appreciably, as well as gene therapy which is still in its infancy and can pose tremendous dangers to the health of the patient like... death. In the former case, you run the risk of developing permanent/semi-permanent parkinsonian syndromes like tardive dyskinesia; of developing neuroleptic malignant syndrome; and, finally, of potentially developing a disposition towards psychosis. And in the latter case, you're going to cause vasoconstriction which may lead to stroke, heart attack, necrosis, and inability to achieve an erection. All of them have it in common that they will take some significant amount of time to resolve the problem. Additionally, all of them have it in common that they may produce no desirable effect whatsoever.

I'm looking for an ideal method, one by which I should restore hedonic tone with surgical precision without interrupting or interfering with the functioning of any other brain regions. I should also like to bypass the brain's goddamn, fucking homeostatic mechanisms. Homeostasis is the enemy of depressed people, all recreational drug users, and all pharmacologists, as well as others within related fields. I wish there were a stronger effort on the part of the intellectuals beset by this horrible thing foisted upon humanity to find ways to circumvent it in certain cases in order to improve the enjoyability of life... Oh, but I wouldn't want to distract you from your search for "novel" stimulants that differ from known stimulants either structurally or pharmacodynamically by a hair's breadth. Please continue to beat your dead horses there, assholes.
 
Last edited:
I work with a professor who studies drug addiction, and is relatively well known that there are genetic isoforms of D2 receptors, long and short. Whether you inherit one or the other is genetic, however researchers have found that in mice with the long allele tend to enjoy drugs more, perhaps due to enhanced euphoria. You (as well as many other people) may have the short allele of d2 receptors that alter the ability to get high as easily from recreational drugs.
 
apoptosis said:
I work with a professor who studies drug addiction, and is relatively well known that there are genetic isoforms of D2 receptors, long and short. Whether you inherit one or the other is genetic, however researchers have found that in mice with the long allele tend to enjoy drugs more, perhaps due to enhanced euphoria. You (as well as many other people) may have the short allele of d2 receptors that alter the ability to get high as easily from recreational drugs.
Click to expand...

I thought everyone had both, and that genetics determine and the use of certain drugs change the D2l/D2s ratio in the NAc and VTA.
 
well, fair enough there shibireru, a good post too. (did it really need to be posted twice though?!)

I have heard of anhedonia before though don't claim to be an expert.
You clearly know your stuff on this matter.
However in my defense i was by no means laughing at the condition.
from what I have encountered personally, anhedonia or the inability to feel/reduction in experiencing "pleasure" through usual dopamine pathways is often the case when the person in question is depressed or suffering from some such affliction.
for example i knew a girl who suffered from M.E after extreme and prolonged base amphetamine usage who complained of such a problem.
also i know a friend who literally reports feeling no pleasure at all from what would be usually pleasurable things (eg sexual climax) again through prolonged use of various substances.
i'm sure there are millions of cases of this affliction, these are just ones i have seen.

i guess i should have phrased my post more succinctly, but i was wondering what the idea of "high" was in this case, and which substances had been used to try and achieve said "high".
I guess euphoria is the obvious one but any more details available?

i still stand by, though do correct me please if i am wrong, that whilst the euphoric "high" may not be reached due to some such mental condition, it surely can not be possible, that all substances in all dosages have no effect on the candidate whatsoever (whether it be psychoactive, psychedelic etc)

i would like to know more.

good luck and please post anything else on this condition.
(though resorting to insults helps no one i feel)

DJ
 
jstn789 said:
Well, I have tried weed, valium, morphine, ritalin, alcohol, percocet and oxys. I have pain sometimes, but whether I have pain or not..nothing works. Does that matter? I didn't think that would be important.

I don't think I would have a tolerance to any. I've gone 4 - 6 months without doing some and then I go back and try and I feel nothing.

I try not to mix drugs, but a couple times I took Oxy with Dex, but it did nothing. Oh, and I took Oxy with muscle relax. can't remember what they were called but someone told me that it feels great...nothing.

I'm not overweight, but I am depressed a lot, I guess. Does this help?
Click to expand...

Then you are the same as me, all the drugs you named dont work on me, even if i take silly high doses.
Try MDMA, Amphetamine or other uppers.
Those drugs you named dont even give me a treshold effect, you are just an upper guy like me:).

Do you have social anxiety?
GHB is the only downer that kinda works, doesnt work for my anxiety tough.
 
You must log in or register to reply here.
Top