fastandbulbous
Bluelight Crew
plus receptor agonism/antagonism i believe are far from the only mechanisms taking place in biological action of LSD at the extreme doses.
Such as?
plus receptor agonism/antagonism i believe are far from the only mechanisms taking place in biological action of LSD at the extreme doses.
That's a surprisingly complicated question. Most of these receptors are G-protein coupled receptors, so when an agonist binds, what it does is stabalize the G-protein into a formation where it's G-protein has high affinity for it, this means that when an agonist binds, G-proteins bind to the receptor more frequently. It's the binding of the G-protein which then causes the subsequent effect in the cell.^^ Are the receptors just on and off switches? Or work more like a transistor?
fastandbulbous said:Such as?
nanobrain said:for example, from GSK's Terry Kenakin's article in An.Rev. of Pharm. & Tox., Vol. 42, April 2002, Drug Efficacy at GPCRs:
"receptor behaviors discussed are activation of G proteins; ability to be phosphorylated, desensitized, and internalized; formation of dimers and oligomers; and the interaction with auxiliary membrane and cytosolic proteins."
...
As I perceive the graph above it looks like the LSD plasma level in the brain reaches a certain point and then bang, the brain cell switches on. I'd imagine it to be alot more complicated than that, as in the brain cell is almost always active, tho the frequency or power of the cell is whats affected. Rather than a simple on or off state.
So in saying that, wouldn't a LSD ingestion from 100 to 200ug have a stronger effect on certain 5htp cells, even tho at <100ug dose those 5htp receptors for those same cells are activated?
fastandbulbous said:As I mentioned previously, considering that you're not going to be activating any extra receptor types/subtypes in the jump in dosage from 1.5mg to say 30mg I can't see that they could be so different except in terms of time to peak, duration of trip etc. Although it may be a very good way of excluding DEA agents from infiltrating the higher echelons of the LSD manufacure & distribution, it also seems to seriously increase the possibilities of long term psychological damage due to the duration of a trip from a 30mg dose.
IMO it's simply not worth the risk - but then I'd be very wary of taking 1500ug in one go; the largest dose I've had is probably about 500ug (4 dots of stronger than average dose in the early 80's) and that left it's mark on me!