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  • BDD Moderators: Keif’ Richards | negrogesic

White Grapefruit Juice

For people who have questions about which drugs it potentiates... here is a great chart and it potentiates any of the 3A4 substrates. (its huge)

NSFW:
cyp450yd7.gif


For further reading, the active constituent of GFJ is Bergamottin.

Reg makes a good point also as many don't find substantial benefit to this form of potentiation. It is more beneficial in extending the effects rather than making them stronger.
 
^ That's not a list of the drugs GFJ potentiates. That's just the list of the inhibitors (drugs which potentiate benzos and opiates), substrates (the enzymes that metabolize the drugs), and the inducers (the drugs that lower the level of the drug in your body).
 
kokaino said:
Grapefruit juice WILL NOT potentiate lorazepam. Lorazepam is in a family of benzos called the 3-hydroxy benzos, which include temazepam, oxazepam, lormetazepam, cinolazepam, and flutemazepam.

These benzos will NOT be potentiated by grapefruit juice at all.

Sorry!
Click to expand...

Right you are, because these benzos are not metabolized by enzyme modification but rather conjugation.
 
^ Yup, which sucks because temazepam happens to be my favorite benzo of all.

Nimetazepam is also metabolized by conjugation like the 3-hydroxy benzos, but it's metabolites (one of them being nitrazepam) are then metabolized via oxidation.
 
Cane2theLeft said:
For people who have questions about which drugs it potentiates... here is a great chart and it potentiates any of the 3A4 substrates. (its huge)

NSFW:
cyp450yd7.gif


For further reading, the active constituent of GFJ is Bergamottin.

Reg makes a good point also as many don't find substantial benefit to this form of potentiation. It is more beneficial in extending the effects rather than making them stronger.
Click to expand...

Naringin as well as Bergamottin.

http://en.wikipedia.org/wiki/Naringin
 
Well its nice to see they have white grapefruit juice. I've searched every gas station i can think of here in florida and all i find is ruby red. ugh this is pissing me off
 
Hey guys does White Grapefruit juice help meds to dissolve faster or just absorption?

I am asking because I know nothing of chemistry and I was wondering if it helps them to dissolve faster, if it would also make them pass through your system faster and make you crash sooner. I hope it's just the absorption!!!!
 
Its actually neither.lol
White grapefruit juice potentiates (makes stronger in effect) certain drugs like opiate/oids by inhibiting an enzyme that metabolizes and helps break down the drug in your liver.
WGJ can double or triple (maybe more it depends on your personal physiology) the effectiveness of these meds and drugs.
Be aware though that BAD side effects like respiratory depression are increased along with the wanted effects.
So, its only something those with a large tolerance should be trying.
 
DuckEcho said:
Well its nice to see they have white grapefruit juice. I've searched every gas station i can think of here in florida and all i find is ruby red. ugh this is pissing me off
Click to expand...

You know the picture of the Ocean Spray 100% White Grapefruit Juice I posted in post #16?

Well, if all else fails (you can't find it in a Wal-mart down there, etc.), you can order it online from here - http://buy.oceanspray.com/Products/...Ocean-Spray-100--White-Grapefruit-Juice-60-oz

Ironically, it says "Florida grown" if you zoom in on the picture. So you'd think that of all the states, FL would be one of the easiest to find white grapefruit for sale in.
 
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