Indomethacin also comes in the UK in capsule form, intended to be taken by mouth. Never encountered any that was meant to be shoved up the chocolate starfish,
Flurbiprofen was probably the best antiinflammatory I got to use, although I don't know if its prescribed here since it came from some foreign pharmacy online. It has additional effects on the endocannabinoid system as well as the NSAID type effects which made it quite a good pain reliever for my fucked up leg and hips (bursitis of the hips, impaled through the joint with a long piece of broken glass, recovering, got the shit kicked out of me by chavscum, stanped on my knee and my head) Its never been right since that. Was a little kid at the time. Had to break the glass off as I couldn't pull it out and walk several miles home, since at the time I didn't own a mobile phone and was a long way from anywhere.
That combined with the assault by pikey trash really messed up my knee, I was left with sharp fragments of broken bone in the joint, plus the patellar tendon, plus some calcification of the tendon, resulted in my gait being altered for the worse, and over time my having to compensate for the injury due to pain (kept being told I could have no help at all with the pain. because I was 'too young' (in the BNF it specifically states that being young should be no barrier to being given pain relief if needed, age should be a factor only in dose and never a reason to refuse analgesia in and of itself), resulted in bilateral trochanteric bursitis, which believe you sodding well me is absolutely agonizing.
I had surgery on the knee but it did nothing good, in fact fucked things up worse, and I was given again, absolutely fuck all for the pain during the recovery phase on crutches, I had to rely on some non-medically supplied DHC 30s and walk round the pharmacies all over the city, on crutches, in serious fucking misery, to round up cough mixtures containing opiates. Operation failed miserably, made the joint worse and left me with nerve damage, its never healed and for many years, I walked with the aid of a staff. Although at times it could be a pain, because it was difficult to get a 2m+ tall staff with me on such things as the city tram lines. There was definitely one plus however. I got very little grief from pikey trash, and the few times some filth of that nature DID try anything, it'd pretty reliably drop the bastards; if some dirty little charvers were a big enough set of cretinous inbreeds to try beating on someone they might have despised, but who happened to be walking, painfully or not, with a staff about 2-2.25x as tall as they are. Gave me quite a range, to say nothing of enormous satisfaction if ever I saw bullies, either someone trying it on personally, or giving other kids trouble, since it gave an enormous reach, and of course being so good for sweeping legs out from under such bullying verminous arselickers, was absolutely hilarious at time
But at a price. The surgery damaged at least one sensory nerve supplying the side of my leg, plus one that must have been involved in inhibitory signalling where muscle tone is concerned, because now I have permanent, unceasing spasticity and tightness, a severe, constant cramping and clenching of the calf muscle that never, ever leaves me, as the muscle can no longer relax on its own. Its really, really painful, the only time I ever get any downtime from it is when I use the strong prescription muscle relaxers that are on my list of rx meds. The oxy I get for breakthrough pain does help a little, but I don't like it much at all. I use it because its all I've GOT for breakthrough pain. I think I'm going to try and get something different for my breakthrough med, as I don't like oxycodone. Either that or try to demethylate some by means of the same rxn that can be applied to DHC or codeine, rxn at -10'C with potassium dodecanethiolate, and KOtBu. On codeine its meant to be almost quantitative in yield. Not sure if it works to demethylate oxycodone to oxymorphone, but worth trying at least.
Sadie darlin' why would I mind. Not as if your removing posted content, just the results of my going ov
And otherwise, my main pain med, morphine sulfate, helps, although not as much as prope, which I've more or less switched to now, because I find it has less negative side effects, but best of all is the great increase in duration. My problem used to be that morphine as I got it came as zomorph XR caps. Very little fillers so it was at least injectable and filtered well, doesn't gel up etc. But even taking cimetidine for my stomach and to inhibit CYP-P450-3A4 and P450-2D6 I still get a dose insufficient to take by mouth, so it has to be extracted from the XR beads and either injected or plugged. The docs won't take its piss-poor oral BA into account whatsoever.
And when I do, natural duration is about 6 hours, with cimetidine (I was on ranitidine to start with, but got my doc to switch me to ranitidine so I could take advantage of its enzyme inhibitor properties. He had no idea what I was talking about to start with, claimed the two drugs were more or less identical, so I explained to him that it would let me get more time out of and more total bang-for-buck out of the morphine and why, and he was alright about that and switched me over) a few hours extra. But converting my weekly morphine allowance to prope, each dose lasts a minimum of 12 hours, 15 is more usual and with larger dose it can go nearly all day from early morning to late evening-early night time; its as long acting as pod tea. And not to mention its easy to KO myself with DPM, for those times it gets too much and I just want to blank everything out for a bit and forget the damned thing that hangs fom my waist to one side of my nackers and aches constantly, the prope dope lets me forget all about it and for a proper, respectable length of time; especially with a couple of heminevrin caps opened, and beaten into an oil-water emulsion then plugged with a disposable syringe (forget using one twice for that stuff, its insanely aggressive towards plastics, welds the barrel to the plunger in no time flat.
Thankfully for the muscle cramp I get a real, working muscle relaxer. I've found most of them to be shitty, and I am a total nonresponder to baclofen, at ANY dose orally. And theres no way, no way in hell I'd willingly try an implanted spinal pump for baclofen. (baclofen is one weird ass drug, some people get nothing at all, at any dose, even at ridiculous levels orally but some of them do respond to the drug delivered intrathecally by implanted pump. But some of the people who get it by spinal infusion pump get no benefit, yet a subset of intrathecal nonresponders find it works for them orally. Odd or whatnow? as for me I was more than happy to switch drugs, and eventually was tried on tizanidine, an imidazoline alpha2 adrenergic autoreceptor agonist thats very similar to clonidine, although its less hypotensive and more of a muscle relaxer, shorter acting than clonidine but its probably the most powerful myorelaxant I have ever tried. Its strong ass stuff, and at first even half a 4mg pill knocked me unconscious. But got used to it enough for that only to happen if I want it to, and say, plug it. It is a true blessing from upon high, though for giving me some relief from the agonizing calf hypertonia. The opiates only relieve the pain unless I go with a knockout dose of DPM and-or oxy,
For the guy speaking of oxynorm-its available in IR capsule form and as liquid. I've only had the liquid twice however, both times it was a bottle given to me on discharge from hospital (the local hospital reliably treats me like shite whilst in there, forgets or CBF maintaining me on my rx meds, but typically, I don't know why, see, to think 2x60ct bottles of heminevrin, a handful of morphine 100mg caps plus a couple of boxes each of oxynorm 10mg caps, 30mg and 10mg zomorph caps, and a massive stash of zanaflex and clonidine and some cimetidine and cyclizine. They are quite irresponsible actually in giving even a highly opiate tolerant patient that much chlormethiazole in particular, but gave me bottles of oxy liquid, one time it was one bottle, another two. And unlike regular dr prescribing they didn't give partial bottles but if needing even a tiny bit over the quantity in one, gave me the entire other bottle. Nice stuff too, works well thinned with water and plugged. It can be shot up but theres so much sugar in it that extraction is likely safer.
What I still don't get is why they usually hand me out quite so MUCH;. Least of all things like the morphine 100 XR caps, which I;ve never had on prescription. Or giving out one, let alone multiple ones of those hospital pharmacy stock bottles of chlormethiazole, as it on;y a;es a few caps over the native tolerance of the user to kill em off.
