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Which psychedelics have a cross tolerance with MDMA?

Okami

Okami

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Joined
Jun 3, 2011
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I took some "acid" on thursday that definately didn't feel like everything else I've gotten as acid. The weird thing on friday I took mdma and I didn't properly come up from it despite it being almost 2 months since last taking mdma and it's quality is definately assured. What psychedelics fit on blotters and would cause this sort of tolerance?

N.B. Please note this isn't a what did I take thread, I haven't tried describing the effects of this fake acid. I want to know what psychedelics are also seretonin releasers (I'm assuming that's the mechanism of the cross tolerance?).
 
It does not necessarily have to be serotonin release, it could be reuptake inhibition as well from something like 5-MeO-AMT or dopamine action from a DOX compound. It is not impossible it was something like 25I-NBOMe, even though it does not cause direct release of monoamines strong serotonergic action might have a result like this since there was only 1 day in between.

Maybe you should reconsider taking something like MDMA the day after a mystery compound next time, whatever it is.

And I can tell you this thread is going to be very short anyway. Because even if you did not describe the direct effects of the thursday trip, preventing you from rolling on friday is an indirect effect that causes you to start an ID thread - you saying that is not the case does not make it so (or, 'not-so'). Because that is obviously still the point here: trying to figure out what substance there are that have a speculated interaction.
 
Well I was hoping to get some clues so that I could find out what reagents to buy to test the blotters I have left over.
 
I've read that Marquis reagent may react with blotter paper, Ehrlich's reagent may be a better bet for testing blotters.
 
Solipsis said:
It does not necessarily have to be serotonin release, it could be reuptake inhibition as well from something like 5-MeO-AMT or dopamine action from a DOX compound. It is not impossible it was something like 25I-NBOMe, even though it does not cause direct release of monoamines strong serotonergic action might have a result like this since there was only 1 day in between.
Click to expand...
Wait, what? When has there been found "dopamine action" with the DOx? I'm very interested, do you have some links maybe?
The DOx sure has a lot of side effects that could be ascribed to some kind of release of dopamine, but when I've asked around, absolutely everybody always insist that they are "pure" 5HT2a agonists.

on topic, isn't MDMA also a mild 5HT2a agonist? If it is, a slight decrease in effect from almost every serotonergic psychedelic should be expected.
 
Not to the extent that there was and surely the stimulation would still be present but there was almost none. The psychedelic that I took was very stimulating apperently reminiscent of meth. Is there a meth and MDMA cross tolerance :)?
 
Yes, I'm sure there'll be cross tolerance between methamphetamine and MDMA. I'm no expert on the pharmacology of MDMA, but I think that the stimulating part of the MDMA roll comes from dopamine release.
 
I have had a very dull MDMA + 6-APB + TMA-6 experience a week after a 25I-NBOMe trip... I would imagine the high affinity from the NBOMe's to play a mayor role in their tolerance development.

I don't remember THAT kind of crosstolerance between mushrooms and MDMA for example.
 
blazR said:
I have had a very dull MDMA + 6-APB + TMA-6 experience a week after a 25I-NBOMe trip... I would imagine the high affinity from the NBOMe's to play a mayor role in their tolerance development.

I don't remember THAT kind of crosstolerance between mushrooms and MDMA for example.
Click to expand...

An entire week after? I've had pretty much expected mdma experience with no noticeable tolerance at 4 day festival where on day 1 I took 2c-b, day 3 real acid (a strong dose). The fourth day I dosed MDMA and if there was a cross tolerance it was no where near to this degree.
 
Yes, an entire week after 25I-NBOMe..

I've had experiences like you, not noticing any kind of cross tolerance between "regular" 2c's and MDMA.
 
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