User145667
Bluelighter
- Joined
- May 30, 2019
- Messages
- 154
You know what I mean? Anyone who has drank Opium Tea knows that there is a very long duration (12-16 hours long if one has low tolerance, and still a good 5-8 hour effect for those who have "duration tolerance," and who would normally only feel traditional opioids for about 1-3 hours these days; at least IME). It's almost like God created Opium as an all natural "OxyContin" or "MS Contin" type of pain reliever.
(And, while we're on the topic, it also seems like God created Kratom---which I like to call "Opium Lite" or "Diet Opium"---to work as an all natural "Suboxone/Methadone" type of treatment opioid. [And in Thailand, it is actually used for this very purpose, as an Opium substitute]. Just like Suboxone, it contains a partial Mu Receptor Agonist---that is, 7-HOM---which happens to have a potency of around 17-30 times the potency of morphine; and similarly, Buprenorphine [Suboxone] also happens to possess a similar potency, and is itself also a partial agonist. Both drugs have a "ceiling effect," both are used to treat withdrawal syndrome, both have mildly stimulating properties, both of them contain both a partial agonist type substance, as well as an antagonist type substance; and finally, both are used buccally [Thai people usually chew the fresh leaves, and thus absorb the goodies through the mouth; Much like the fact that Suboxone is absorbed in the mouth. Oh yeah, and as partial agonists, both have the ability to block other Opioids -- seeing how partial agonists both partially activate the receptor, as well as antagonize/reverse agonize the receptor, to my knowledge. Sorry for the rant, I just found the many parallels really interesting.)
Obviously this "time release" aspect of oral Opium has to be caused by the entourage effect of all or one or a combination of the alkaloids found present in the Opium Poppy plant. Does anyone know *which* alkaloid(s) happens to cause said effect? How does it go about doing this? Does it cause the Morphine to be broken down slower? How does it effect the half life like that? Could you isolate the culprit alkaloid and then pair it with heroin or oxy or Dillies or something and get those drugs to also last significantly longer as well (I have always wondered this lol)? Thanks.
Also, on a kind of unrelated note: does anyone know why Morphine is the only opiate/opioid that causes this really fatigued, almost painful kind of tired feeling on the come up? I even feel it when I shoot it. I never get that from any other opioid, just Morphine. Do you guys know what I'm talking about? What causes that? Just curious lol.
(And, while we're on the topic, it also seems like God created Kratom---which I like to call "Opium Lite" or "Diet Opium"---to work as an all natural "Suboxone/Methadone" type of treatment opioid. [And in Thailand, it is actually used for this very purpose, as an Opium substitute]. Just like Suboxone, it contains a partial Mu Receptor Agonist---that is, 7-HOM---which happens to have a potency of around 17-30 times the potency of morphine; and similarly, Buprenorphine [Suboxone] also happens to possess a similar potency, and is itself also a partial agonist. Both drugs have a "ceiling effect," both are used to treat withdrawal syndrome, both have mildly stimulating properties, both of them contain both a partial agonist type substance, as well as an antagonist type substance; and finally, both are used buccally [Thai people usually chew the fresh leaves, and thus absorb the goodies through the mouth; Much like the fact that Suboxone is absorbed in the mouth. Oh yeah, and as partial agonists, both have the ability to block other Opioids -- seeing how partial agonists both partially activate the receptor, as well as antagonize/reverse agonize the receptor, to my knowledge. Sorry for the rant, I just found the many parallels really interesting.)
Obviously this "time release" aspect of oral Opium has to be caused by the entourage effect of all or one or a combination of the alkaloids found present in the Opium Poppy plant. Does anyone know *which* alkaloid(s) happens to cause said effect? How does it go about doing this? Does it cause the Morphine to be broken down slower? How does it effect the half life like that? Could you isolate the culprit alkaloid and then pair it with heroin or oxy or Dillies or something and get those drugs to also last significantly longer as well (I have always wondered this lol)? Thanks.
Also, on a kind of unrelated note: does anyone know why Morphine is the only opiate/opioid that causes this really fatigued, almost painful kind of tired feeling on the come up? I even feel it when I shoot it. I never get that from any other opioid, just Morphine. Do you guys know what I'm talking about? What causes that? Just curious lol.
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