In the short term, in terms of the feel itself, MXE feels the cleanest, with euphoric psychedelics second, then Cannabis, then non-eurphoric psychedelics - but in terms of the real negative side effects that lay below the surface and come out more as you begin to use the drugs I feel that in the simplest terms, Cannabis would be the safest, followed by psychedelics, followed by MXE not being that safe and being quite addictive.
In most peoples lives I feel psychedelics would come out on top as being the safest, because most people don't take them with the frequency they'll take something like Cannabis. Cannabis comes next, because when taken frequently, daily, as a large number of smokers use it, it can cause paranoia and anxiety, as well as memory and learning problems - if taken sporadically like psychedelics though these issues vanish, and aside from these things it's relatively harm free. Finally comes MXE, this drug has a lot of side effects, both the side effects of traditional psychedelics but also seemingly those of serotonergic empathogens like MDMA etc.. i.e. depression after prolonged use.. alongside these side effects, it's also one of the most addictive and delusional drugs I've tried.
That's not to paint any of them out to be harm free or to be the devil either, all of them should be treated with care and respect, and if proper care and respect is taken, and they are used infrequently, all three can be useful tools imo.
When you say euphoric psychedelics, are you thinking in drugs like amt with strong stimulant properties? Which psychedelics do you consider euphoric psychedelics? sorry if the question isn't very well formulated, english isn't my native languaje.
