Benzos Which lasts longer, oxazepam or lorazepam ?

[Kdeem]

And do they both have a stable effect or have a peak followed by a 'plunge' ?

 

[pinpoint]

From wikipedia (since you're too lazy to search):

The half-life of oxazepam is four to 15 hours.
The half-life of lorazepam is 10–20 hours.

Don't understand your other question.

 

[UnsafePony]

Half life is different to duration of effect and in the case of benzodiazepines the two are generally unrelated. Their duration is pretty similar, about 5-8 hours.

Second question doesn't really make sense, they are a downer and just make you feel calm and relaxed for a few hours and gradually wear off.

 

[MikeRWK]

lorazepam is also stronger being dosed in sub milligram to 1-2mg pills while oxazepam comes in 15mg,30mg pills.

 

[Changa707]

Well as far as half-life go's, it's pretty much irrelevant here...i'd say Oxazepam (Serax) has a much slower onset and longer duration of effects compared to Lorazepam...although the after-effects of Lorazepam seem to last just as long as with Oxazepam (both of these benzodiazepines are known to cause depressive after effects in many people, hence I do not prefer them to Clonazepam or Hypnotics such as Temazepam.

However, compared to Clonazepam and Lorazepam (two very potent benzodiazepines)...Oxazepam is less potent, and considered less abusable than other benzos. For this reason Oxazepam is often the benzodiazepines of choice for physicians to prescribe to patients with histories of addiction/drug-abuse.

One thing I like about Oxazepam however is that it does not overpower opiates when taken in combination. Although I do not advise mixing benzodiazepines and opioids, Oxazepam is nice to mix with low-dose opioids...just remember to take the Oxazepam about 1.5 hours prior to taking the opioid (it has a slow onset).

Have fun and be safe! Happy 2015

 

[Kdeem]

Thanks for the responses.

I had already tried oxazepam. After taking about 1.5 hours to start taking effect, the effect/action would be strong/medium in strength (dose related), followed by a three to four hour effect that I would call 'very mild'. After that, nothing.

Should I expect the same from lorazepam ?

 

[MikeRWK]

As someone who was prescribed both at different times for weed wd, the ativan (lorazepam) is stronger.Also the can both be taken sublingually, which is placing them under your tongue and letting them melt.

 

[cook]

Oxazepam is one of the weakest benzodiazepines and lorazepam one of the strongest. Youll get faster and stronger effects from loraz, but it is also much more physically addictive.

 

[phatass]

Briefly i feel the need to chime in to this!
Oxazepam is amongst the best benzo's for treating GAD IMO, we have 50mg oxazepam pills here, if you take one in the morning one at lunch and one at dinner time, you're "covered" for the day IME duration of action is approx 4 hours, remember 50mg's oxazepam is "equivalent" to 25mg's valium, or 1,25mg xanax or 2.5mg lorazepam, that's a high dose to take 3 times daily. I was Rx oxazepam 50m's 3x/day and it worked well for me because it has less abuse potential than many other benzos IME, also it's anxiolytic effect is very efficiant and very much pre-dominant, with little muscle relaxation and quasi no hypnotic effects, hence it doesn't "stop working" like many experience when taking valium daily for example... the stable anxiolytic effect of oxazepam didn't warrant or necessitate to increase dosage.

Lorazepam i took for 2 weeks or a month, so have little personal experience with it compared to oxaz which i was on for years, i didn't understand why lorazepam from what i had read had so little rec value for me (neither did clonazepam strangely), when lot's of rec benzo (ab)users were raving about it... none the less from the little personal experience but especially from what i've read, lorazpam seems to have a higher abuse potential... Also lorazepam can be sublingualed and so will have a rapid onset, which generally means one will tend to do more compulsive re-dosing which they would not do with slower onset benzos... Especially if you've been addicted and/or abused drugs in general...

If you intend to use it
-Therapeutically: Go for oxazepam IMO
-Recreationally: Go for lorazepam IMO

my 0.2
peace

 

[AlphaMethylPhenyl]

I have also heard that oxazepam has less potential for abuse.

 

[MikeRWK]

I have also heard that oxazepam has less potential for abuse.

I would agree it does have less potential.

 

[cook]

I never did stupid things on oxazepam but on loraz its so easy to almost black out and stuff. Not that its recreational but it just way stronger somehow. For some of you it may be exotic but here it is first line benzo you will get from a doc, very slow onset and quite short duration and is quite sedative.

 

[MikeRWK]

I got my hands on like 20 2mg kpins trying to use them the same as serax (oxazepam) to quit smoking weed, they just didnt do anything so I'd pop more.I had 4-6mg in me one night and drank 12 or so beers, was at my cousins whose house was like 1ft away from the neighbors so I went outside and sat at the neighbors picnic table thinking it was his.He took me inside gave me a line of blow I was good for like 20 mins then fucked so I went to bed.

I know its not an exciting story but still I was fucked up.

 

[Nom de Plume]

I can't even feel either of them. I'm truly astonished anyone could. I was once prescribed lorazepam, but implored my doctor to switch to another drug as I felt it was mere placebo.

Edit: You know, on second thought, benzodiazepines really fucking suck in comparison to barbiturates. While I am aware of my discursion, I'm very curious who in the hell duped whom into replacing the former with the latter. The paranoid DEA? The bovine public? The venal pharmaceutical industry? The superlative prescribers? All or possibly none of these?

 

[Changa707]

Nom de Plume, there was never a conspiracy against barbituates or anything like that...within weeks of Mandrax (old trade name for quaaludes) hitting the market, physicians were already aware of their strong abuse potential. Although Mandrax (Methaqualone) isn't exactly a barbituate, it has a similiar effects & toxicity profile to other barbituates.

Not to mention, barbituates have a much lower LD50 than benzodiazepines...hence why the latter replaced the former eventually.
Sure, you could argue that there is a lot of hype surrounding barbituates...especially Mandrax, but in reality most barbituates aren't that great anyways unless IV/IM'd (not that I ever have). But I imagine it would be rather difficult to tell apart Valium and Mandrax in a double blind experiment. When Valium first hit the market in the 60's it was incredibly popular, but it would be untrue to say it replaced barbs completely...the barbitals still have their time and place, but basically because of their toxicity profile they are less commonly prescribed to humans these days (hence why dogs get phenobarbital, it's cheap and effective...but at the cost of saftey.)

I don't have any experience with barbituates, though I have talked with some old school Mandrax users and most of them have very fond memories of the drug. I have often heard people compare the feeling to "that of being a butterfly"...just floating around peacefully.
At the end of the day, barbituates are probably no less dangerous than benzodiazepines if you are a responsible drug user...that means that you have done your research and have an understanding what you are doing. But sadly most people are rather uninformed about drugs, hence why physicians replaced the more dangerous barbituates with the less dangerous benzodiazepines...it has probably saved a lot of lives over the years.

Which barbituates have you tried btw?

 

[cook]

This is getting derailed but Methaqualone is the one sedative id like to try before I die. I just want to know is there anything special but nostalgia behind the hype.

 

[Nom de Plume]

This is getting derailed but Methaqualone is the one sedative id like to try before I die. I just want to know is there anything special but nostalgia behind the hype.

Yes! I think the drug is under-hyped, especially in Europe and North America. We're talking about a drug that's easier to make than MDMA, yet is no where to be found on the streets of nearly every town in these two continents. It is incredibly odd.

In my own experience, you can very easily get very pure methaqualone, or at least one of its derivatives, anywhere in South Asia and southern Africa (especially South Africa, but apparently also in Namibia, Botswana, Lesotho, and other adjacent countries). I'd say Mandrax is about as difficult to acquire in, say, India, as cocaine is in America.

 

[Nom de Plume]

Nom de Plume, there was never a conspiracy against barbituates or anything like that...within weeks of Mandrax (old trade name for quaaludes) hitting the market, physicians were already aware of their strong abuse potential. Although Mandrax (Methaqualone) isn't exactly a barbituate, it has a similiar effects & toxicity profile to other barbituates.

Not to mention, barbituates have a much lower LD50 than benzodiazepines...hence why the latter replaced the former eventually.
Sure, you could argue that there is a lot of hype surrounding barbituates...especially Mandrax, but in reality most barbituates aren't that great anyways unless IV/IM'd (not that I ever have). But I imagine it would be rather difficult to tell apart Valium and Mandrax in a double blind experiment. When Valium first hit the market in the 60's it was incredibly popular, but it would be untrue to say it replaced barbs completely...the barbitals still have their time and place [...]

There's just so much I could say about these two paragraphs that I don't think I'll comment on them. I actually composed a response but after about 1,500 words, I realized it was far too lengthy to be appreciated on an Internet forum. So I just saved it as a file and decided against submitting it.

[...]but basically because of their toxicity profile they are less commonly prescribed to humans these days (hence why dogs get phenobarbital, it's cheap and effective...but at the cost of saftey.)

Too many good drugs are wasted on these damned animals! I should really become a veterinarian. Or, better yet, a dog.

I don't have any experience with barbituates, though I have talked with some old school Mandrax users and most of them have very fond memories of the drug. I have often heard people compare the feeling to "that of being a butterfly"...just floating around peacefully.

Ah, yep! I love this drug so goddamned much. It's pro-sexual, but better than sex, I think. I dare say, if one doesn't enjoy the high of methaqualone, they have no soul. It's a damned shame such a wonderfully supernal substance is illegal.

At the end of the day, barbituates are probably no less dangerous than benzodiazepines if you are a responsible drug user...that means that you have done your research and have an understanding what you are doing. But sadly most people are rather uninformed about drugs, hence why physicians replaced the more dangerous barbituates with the less dangerous benzodiazepines...it has probably saved a lot of lives over the years.

You cannot prevent the death of a sufficiently determined oaf. Somebody somewhere will find a way to die, no matter how safe and idiot-proof something is. But why must we all suffer because of the idiots amongst us? Should no one be allowed to bathe without a personal flotation device and a lifeguard present just because some feather-brained fuck manages to drown in an ankle-deep puddle of water? How far are we willing to take this effort to slow down the process of survival of the fittest? How many privileges are we going to relinquish all for some futile protection of the least amongst us?

Which barbituates have you tried btw?

Wow, really?! Is "many" a sufficient answer for you?

Do note the fact barbiturates are not difficult to synthesize sub rosa—by dint of their easily obtained precursors, lab accoutrements, etc. Quinazolinones and GHB are easier, but benzodiazepines are more difficult, in my opinion. Mind you, it is never terribly easy to commit a felony without getting caught. But it isn't lsd or something. This would (erhm, theoretically of course, of course) make it relatively simple for a determined and reasonably intelligent individual to make just about any barbiturate, vastly enlarging one's diapason of downers.

 

[beforethebeginning]

barbiturates can cause steven johnson syndrom and event hough its rare,
its enough for me not to want to try them.

it's like how some people get burned by certain antibiotics.

 

[MikeRWK]

Yes! I think the drug is under-hyped, especially in Europe and North America. We're talking about a drug that's easier to make than MDMA, yet is no where to be found on the streets of nearly every town in these two continents. It is incredibly odd.

In my own experience, you can very easily get very pure methaqualone, or at least one of its derivatives, anywhere in South Asia and southern Africa (especially South Africa, but apparently also in Namibia, Botswana, Lesotho, and other adjacent countries). I'd say Mandrax is about as difficult to acquire in, say, India, as cocaine is in America.

I'm guessing no dealer in america wants to sell this since the risk may out weigh the reward, and you'd probably get some crazy retarded sentence if caught just to make an example and be portrayed as a monster/killer.