• N&PD Moderators: Skorpio

Which enzymes are responsible for the metabolisation of Baclofen?

CYP2D6

Greenlighter
Joined
Apr 27, 2012
Messages
17
I've scoured the internet and can't find out anything about specific enzymes.
 
WIki says most of the drug, 85%, is excreted unchanged and 15% is deaminated, probably by something like phenylalanine deaminase...
 
I know that phenibut is excreted unchanged through the urine. Baclofen is just the para-chloro derivative of phenibut. 85% is excreted unchanged. The 15% that gets deaminated is probably done so via GABA-transaminase, glutamic acid decarboxylase and succinic semialdehyde dehydrogenase.
 
Last edited:
Top