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  • BDD Moderators: Keif’ Richards

when drugs are taken orally and subligually do the BA% change?

Jabberwocky

Jabberwocky

Frumious Bandersnatch
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Nov 3, 1999
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i hear people do it for a quicker onset, but does more/less of the drug get absorbed? thinking about trying my adderall sublingually

i heard taking magnesium or tyrosine WITH adderall potentates it
 
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Tyrosine along with adderall may potentiate the effect of the adderall, but not in the sense of increasing the amphetamines BA. Tyrosine acts as a precursor to both dopamine and norepinephrine, and adderall works by increasing these neurotransmitters presence in the brain and preventing their metabolism. So having more dopamine and norepinephrine present will potentiate the effect of adderall...theoretically.

And as far as drugs being taken orally or SL, it depends on the drug. I'm not sure if sublingual adderall will cause a higher degree of absorption, it's not formulated that way. Though holding the adderall under your tongue for a bit and then swallowing it when you're done can't hurt...if it doesn't absorb SL you're going to be swallowing it anyway, so it'll get there one way or another.
 
Benzos already have a really high oral BA (at least the common ones) but they certainly hit you quicker if you use them sublingually. At least lorazepam does, but then again it is designed for that (quicker = better when combating panic attacks).

A quick Google search doesn't turn up very much useful information, many a benzo expert can chime in.

As far as magnesium with amphetamines goes, I don't know if there's any potentiation going on, but magnesium certainly helps with the amphetamine comedown back pain that I know a lot of people get...I've been getting it worse and worse lately but magnesium certainly helps.

Are you taking it as magnesium oxide or another form?
 
delta_9 said:
Yes.
Orally taken compounds are subject to the 1st pass effect.
Any other ROA bypasses this initial metabolism.
The difference in BA may not always be significant, but the pharmacokinetics are entirely different for a compound taken oral vs sublingual.
Click to expand...

so taking oral compounds SL is gives a higher BA%?
 
It depends on the nature of the molecule of the drug...sometimes a drug molecule will not absorb until it is in the very acidic contents of your stomach, and other drugs conversely will not absorb until in the alkaline environment of your intestines. Some drug molecules are too large to pass across the membrane of the capillaries under your tongue. Some drugs require bio-activation in your liver before they exhibit their pharmacologic properties, in which case you'd need to ingest the drug first before getting an effect. SL administration does not always equate to instantly higher BA, it all depends on the drug.
 
K'd-OUT-in-AZ said:
Please expand on your answer. I'd like to know because as far as I know it always will (not saying the BA% will always increase, saying it will always be better absorbed). I could be wrong so I'd like to know why your saying not necessarily
Click to expand...

Drug absorption is a highly variable process.
A drug can be absorbed many ways(active diffusion, passive diffusion, endo or exocytosis), and many factors of the drug itself play a significant role(pH/pKa, lipid/water solubility, ionization, 'prodrug' status, etc.)
Drugs administered sublingually will be absorbed faster into systemic circulation, but not always necessarily better.

*(Assumed by 'better' absorption you meant 'more complete')
 
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