I really tend to go with how much I feel i need on the night. If one is enough than one is enough. Very rarly will i go over 2. Three would be my upper limit. After that its just a waste of money, not to mention the fact that your just going to fuck your brain harder and harder. After a year and half i'm still taking halfs, or half points of md powder, so I figure i must be doing something right for the moment.