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  • N&PD Moderators: Skorpio

What's the simplest psychoactive molecule?

I think there are two reasons why Propanol (N-Propanol) has not been used recreationally:

1. Almost everyone confuses it with Isopropanol, which is metabolized into Acetone and is therefore toxic.
2. It is almost impossible to acquire (it seems to be a controlled substance?). Even photography supply stores are hesitant to sell it.

From what I heard, N-Propanol is not converted into anything toxic.

I believe Haribo tried it (or at least has a lot of info about it).

As for Isopropanol, even if you're not too worried about Acetone, it is still a HORRID irritant. I tried drinking it a long time ago and was unable to finish the shot from the pain (and experienced no psychoactive effects at that dose, but I have a tolerance). I have a feeling it is a great way to induce all sorts of GI horrors.
 
^ About 1.: Acetone is not THIS toxic. Not relevant in this case. (or minor relevant)
About 2.: Hard to aquire?! Or just unusual? IMO not controlled.

n-Propanol has the same toxic metabolites like methanol and ethanol as well: The respective aldehyde and the carboxylic acid (propanal and propanoic acid), both should be less toxic compared to acetaldehyde resp. acetic acid (reactivity at the carbonyl-carbon is slightly lower).

And you took indeed PURE iPrOH?! Baaah... aweful!! I wouldn't even drink pure EtOH! I prefer it well diluted, down to ~40%. They call it 'Wodka' here. ;)

These alcohols are all GI irritants due to their denaturating ability on proteins of all kinds.

Peace! Murphy
 
^ Lol yes, it was plain rubbing alcohol :D

One thing that confused me: you say that n-Propanol has the same metanbolites as methanol and ethanol, then you explain that saying that propanal and propionic acid are less toxic than acetaldehyde (which is what I had in mind when I said it was less toxic than ethanol). Was that just an error? Also, I think we all would agree that methanol's metabolites (formaldehyde and formic acid) are not exactly the "same" as ethanol and propanol, wouldn't you agree?

As for acquiring it, I was personally unable to do so (given I don't have a lab chemist license of any kind) despite exhausting all my resources. *shrug*
 
Maybe I confused it, so again in short:
The 4 alcohols (MeOH, EtOH, iPrOH, nPrOH) do of course not have the same metabolites, because carbon-chain length (and branching) are different. Rhetorical, isn't it?
But all metabolites share the same functionalities, going from the alcohol to carbonyl, then to the carboxylic acid (except iPrOH, which stops at the carbonyl).

The longer the chain, the lower should toxicity get, at least in this C1-C3-range. The (toxic) actions of MeOH's metabolites are more or less the same like EtOH's, but FAR more effective. I know, this is bit simplified but still correct IMO. Don't forget that all simple primary alcohols share this toxicity.

Murphy
 
Murphy, while there is no question that they have the same chemical properties, the fact that Methanol causes blindness and others don't tells me that their toxicologies are at least slightly different.

Where is mrs. F&B? =D
 
MurphyClox said:
But all metabolites share the same functionalities, going from the alcohol to carbonyl, then to the carboxylic acid (except iPrOH, which stops at the carbonyl).
Click to expand...

It's further metabolized to lactic acid.

Mice were found to convert acetone to lactate at appreciable rates. The conversion of acetone to gluconeogenic precursors could provide additional glycolytic intermediates that would allow the more complete utilization of lipid stores and increase survival time during starvation. In mice that were starved for 3 days or were provided with acetone in the drinking water the acetone-metabolizing pathway was induced to levels severalfold normal. Mice heterozygous for obesity-producing mutations, either obese (ob/+) or diabetes (db/+), showed induction of the activity of this pathway to a significantly higher degree than did homozygous normal (+/+) mice of the same strain. This more effective conversion of acetone to lactate exhibited by heterozygous mice could account for their prolonged survival on a starvation regimen compared to that of normal homozygotes. The rate-limiting step in the pathway appears to be the conversion of acetone to a hydroxylated derivative. The enzyme system effecting this conversion is an NADPH-requiring microsomal oxygenase found in the liver.
Click to expand...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=348255

Acetone is a natural product of ketosis in man.

Here's a really old but interesting study into the injecting of humans with acetone: http://www.jbc.org/cgi/reprint/140/3/811.pdf
 
There's actually a trip report somewheres on Bluelight for n-propanol. There was a guy, whose name escapes me, that ordered it from a chem supply company and tried it, and posted the results - I seem to remember that it was a drunkenness comparable to ethanol, but it lasted much shorter.
 
Yep, it's haribo as I expected:

http://www.bluelight.ru/vb/showthread.php?t=294236

Just because I'm stupid, I read up about N-propanol (not isopropanol) intoxication. Seems like the stuff is 3-4 times more potent than ethanol but since you need less of it, you sober up a lot quicker. So, next step was to buy some lab-grade N-propanol. Well, I dissolved 50ml into 500ml of grapefruit juice & drank 100ml. Man, I was drunk in 10 minutes and stone sober in 2 hours with no hangover. Has anyone else tried this? I know that it's supposed to be a lot less harsh on the body and there are no recorded cases of people dying through intoxication.
Click to expand...

Sounds much better than ethanol to me. I'd do anything to be able to sober up so quickly after my last drink.
 
I've tried both n-propanol and isopropanol, of course, in small quantity.

The intoxication is like the confusing and uncoordinating of ethanol, but less social and euphoria. also the duration is short (which might be from the low amount bioassayed)

I wont try butanol tho, butanoic acid will make the sweat rancid like old damp sock!
 
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