paliperidonevictim2005
Bluelighter
- Joined
- Aug 30, 2023
- Messages
- 680
??
-
BDD Moderators: Keif’ Richards
What's the safest drug out of these 3 nitrous oxide, MDMA, or codeine?
- Thread starter paliperidonevictim2005
- Start date
notsmokeymcpot42088
Bluelighter
- Joined
- Apr 5, 2025
- Messages
- 4,211
Codeine 100% as long as you 1) Know that it is codeine 2) Dose appropriately Addiction and overdose are your concerns but OD on codeine takes a bit
Nitrous oxide -- Drains B vitamins and all kinds of other stuff - especially if you are doing "Whippets" not a regulated steady nitrous to oxygen ratio. Also black out and smash your head quite often. People have been known to seize.
MDMA --- The MA stands for methamphetamine -- but really the main problem is MDMA is usually cut. You got and know how to use marquis reagent it is only MDMA -- still more dangerous than codeine but not that dangerous
Nitrous oxide -- Drains B vitamins and all kinds of other stuff - especially if you are doing "Whippets" not a regulated steady nitrous to oxygen ratio. Also black out and smash your head quite often. People have been known to seize.
MDMA --- The MA stands for methamphetamine -- but really the main problem is MDMA is usually cut. You got and know how to use marquis reagent it is only MDMA -- still more dangerous than codeine but not that dangerous
It may be better to frame the question as "Which of these three is the least harmful/risky?". Perhaps it's pedantic but we're looking at this from a harm reduction perspective and it's probably not prudent to call any drug 'safe'.
And is this question about which is least harmful for a one-off use or for regular use?
I'd probably agree with notsmokeymcpot's answer above: codeine. Aside from the possibility of histamine reactions, stomach discomfort, and constipation, I don't think codeine causes any direct harm to the body. I'm not 100% sure about that, but compared to other drugs which often have well-known negative effects on the body (e.g. ketamine and bladder issues, cocaine and heart problems) I don't hear much about codeine.
And is this question about which is least harmful for a one-off use or for regular use?
I'd probably agree with notsmokeymcpot's answer above: codeine. Aside from the possibility of histamine reactions, stomach discomfort, and constipation, I don't think codeine causes any direct harm to the body. I'm not 100% sure about that, but compared to other drugs which often have well-known negative effects on the body (e.g. ketamine and bladder issues, cocaine and heart problems) I don't hear much about codeine.
notsmokeymcpot42088
Bluelighter
- Joined
- Apr 5, 2025
- Messages
- 4,211
I meant codeine was %100 the least harmful of the three drugs not 100% safe. (Most people with codeine allergies are actually just having a heavy histamine release, which is completely normal "Opiate itch")
There is a reason that codeine is OTC in Canada combined with Tylenol -- and the Tylenol is the more harmful part. (Hence the CWE).
Codeine is the safest to use once out of the three and it is the safest to use "Regularly" is a big word as opiates do tend to be addictive. Codeine is a pretty small ante in the opiate world even if you were to become addicted...
MDMA -- Can only use about once a month (Really less for full effects) - Taken with SSRI's or MAOI's can cause SEROTONIN SYNDROME. and again that is IF what you are getting is pure MDMA (Which in reality it usually is NOT FOR MOST PEOPLE)
Nitrous oxide -- To experience a true nitrous high you are going to need a steady oxygen to nitrous ratio -- which is inherently dangerous as you need air to breathe! Many M.D's dead this way! Go the other way and do whippets all you get is a headrush and some whom whom whom tinnitus at great cost of vitamin B. (Pretty sure) I wanna say D or E become a problem too. But I have never been down that road
There is a reason that codeine is OTC in Canada combined with Tylenol -- and the Tylenol is the more harmful part. (Hence the CWE).
Codeine is the safest to use once out of the three and it is the safest to use "Regularly" is a big word as opiates do tend to be addictive. Codeine is a pretty small ante in the opiate world even if you were to become addicted...
MDMA -- Can only use about once a month (Really less for full effects) - Taken with SSRI's or MAOI's can cause SEROTONIN SYNDROME. and again that is IF what you are getting is pure MDMA (Which in reality it usually is NOT FOR MOST PEOPLE)
Nitrous oxide -- To experience a true nitrous high you are going to need a steady oxygen to nitrous ratio -- which is inherently dangerous as you need air to breathe! Many M.D's dead this way! Go the other way and do whippets all you get is a headrush and some whom whom whom tinnitus at great cost of vitamin B. (Pretty sure) I wanna say D or E become a problem too. But I have never been down that road
HealingEnergy14
Bluelighter
- Joined
- Feb 22, 2025
- Messages
- 166
I'd disagree, codeine is the most dangerous one out of the three in my opinion.
Codeine increases histamine (known to increase cancer risk) and makes you constipated. Constipation is one of the most dangerous and overlooked problems in health. It causes all kind of downstream problems when your body can't remove waste properly.
Now obviously, either of these three drugs is fine to use once for healthy people and won't instantly cause problems provided they know what they are getting themselves into.
Your argument about Nitrous Oxide "draining" (from my understanding it more limits your body's ability to use vitamin b12, but i suppose that is a bit of semantics) B vitamins is true, yet for a healthy person this is absolutely not a problem.
Someone with a vitamin B deficiency could instantly come into trouble with Nitrous, same with say someone with a serious alcohol problem. Most people will be absolutely fine doing Nitrous Oxide a few times though.
I'd say addiction-wise codeine is also the most dangerous; a person that is finding himself in a bad spot in life is more likely to enjoy and find an escape in the opioid-high/warmth that codeine provides.
While MDMA and Nitrous Oxide certainly can be used to escape reality, they also allow the user to see their lives in a different perspective and gain some insights that might be useful even when sober afterwards.
My ranking for safest 1 time usage would be:
1: Nitrous
2: MDMA
3: Codeine
notsmokeymcpot42088
Bluelighter
- Joined
- Apr 5, 2025
- Messages
- 4,211
Harm Reduction wise I stand by my statements.
A single use or even semi regular codeine usage should not cause constipation. Cons, Addiction/(Dependency) and Histamine release *Lots of things cause histamine release*. (Benadryl will stop histamine release if you a re concerned about that very very small chance of cancer. --- How strongly does histamine release promote cancer and could I see where that info is coming from? (An I don't have it or just don't supply it and I will figure you don't)
--"long-term use of opioids, including codeine, may be linked to an increased risk of developing cancer. However, this association is still under investigation" = They wish it may they rant it might....
--The connection between histamine and cancer is complex, but in simple terms, cancer can cause the body to release high levels of histamine, which can promote tumor growth and interfere with the immune system's ability to fight the cancer.
(like the cancer comes before the histamine is a problem was my interpretation?)
We have all known ppl that were 'addicted' to MDMA or Nitrous in the psychological sense. Hence nitrous being called "Hippy crack" it is very "more-ish" as is MDMA (hence people have a problem keeping it to once a month or under)
(Which is the technical definition of addiction - I don't agree, physical dependence is a high level addiction imo - but not the medical communities)
Let me ask the question this way; if you had to know a loved one (In regular health) was doing one of these drugs once every two weeks - once a week even - would you still have them in the same order?
Well you are wrong than! lol codeine is OTC for a reason.
Nitrous you can get over the counter but not for human consumption and ppl be steady catching headrushes falling over hitting they heads -- plus the seizures and vitamin deficiency.
MDMA you simply can't use once a week. So if you can stick to once every other month and you are 100% what you have is just MDMA -- Maybe Maybe that would be safer. I don't think so honestly but there is room for subjectivity.
I definitely know ppl that have been to the hospital from MDMA and Nitrous and ppl that have overdosed (In nitrous case, seizure whippets. make a rig you risk oxygen though -- I have never seen anyone in the hospital from codeine (Not Tylenol codeine). Seen the hospital give a lot of people codeine.
Ok I rest my case. lol
A single use or even semi regular codeine usage should not cause constipation. Cons, Addiction/(Dependency) and Histamine release *Lots of things cause histamine release*. (Benadryl will stop histamine release if you a re concerned about that very very small chance of cancer. --- How strongly does histamine release promote cancer and could I see where that info is coming from? (An I don't have it or just don't supply it and I will figure you don't)
--"long-term use of opioids, including codeine, may be linked to an increased risk of developing cancer. However, this association is still under investigation" = They wish it may they rant it might....
--The connection between histamine and cancer is complex, but in simple terms, cancer can cause the body to release high levels of histamine, which can promote tumor growth and interfere with the immune system's ability to fight the cancer.
(like the cancer comes before the histamine is a problem was my interpretation?)
We have all known ppl that were 'addicted' to MDMA or Nitrous in the psychological sense. Hence nitrous being called "Hippy crack" it is very "more-ish" as is MDMA (hence people have a problem keeping it to once a month or under)
(Which is the technical definition of addiction - I don't agree, physical dependence is a high level addiction imo - but not the medical communities)
Let me ask the question this way; if you had to know a loved one (In regular health) was doing one of these drugs once every two weeks - once a week even - would you still have them in the same order?
Well you are wrong than! lol codeine is OTC for a reason.
Nitrous you can get over the counter but not for human consumption and ppl be steady catching headrushes falling over hitting they heads -- plus the seizures and vitamin deficiency.
MDMA you simply can't use once a week. So if you can stick to once every other month and you are 100% what you have is just MDMA -- Maybe Maybe that would be safer. I don't think so honestly but there is room for subjectivity.
I definitely know ppl that have been to the hospital from MDMA and Nitrous and ppl that have overdosed (In nitrous case, seizure whippets. make a rig you risk oxygen though -- I have never seen anyone in the hospital from codeine (Not Tylenol codeine). Seen the hospital give a lot of people codeine.
Ok I rest my case. lol
Last edited: