What's the LD50 for paracetamol?

[akkeri]

...or, what's the most i should take?

just wanted a couple more Panadeine Forte (30mg Codiene; 500mg Paracetamol) before bed -- can't be bothered with an extraction tonight.

 

[soundphaRm]

The most that is recommended to take is no more than 4000 mg/24 hr. period. This is not the LD50, though...here is what the PDR says..:

"Acetaminophen in massive OD may cause hepatic toxicity in some patients. In adults/adolescents, hepatic toxicity has rarely been reported following ingestion of acute ODs of less than 10g. With the proper supportive measures, fatalities are infrequent & have rarely been reported w/ ODs of less than 15g.
In children, an acute OD of less than 150 mg/kg has not been associated with hepatic toxicity."

Of course, that doesn't mean it's good for you, but that's what the PDR says...

 

[fastandbulbous]

In the UK, a hospital will start an acetylcysteine drip if the dose of paracetamol is over 12g (24 x 500mg), but doses less than that will damage your liver to some degree (doses over 4g)

 

[Limpet Chicken]

Fastandbulbous, I seem to recall that methionine was a specific antidote to paracetamol toxicity, you don't happen to know how it detoxifies APAP do you?

I have had close friends and previous other-halfs go through this shit so many times, once, I had to RUN around 6-7 miles non-stop to get to the workplace of a girl I was seeing, who told me by phone had OD'ed on paracetamol, and have the paramedics take her to the hospitalm they arrived just as I got there.

I am actually considering buying a bottle of methionine, just in case this ever happens to me again.

 

[nanobrain]

paracetamol is hepatotoxic in humans at doses well below the 4,000 mg especially when coadministered with alcohol - reading a report on it as we speak.

do not take that shit at all if possible.

 

[sourlemone]

seriously, if you want easy to get codeine (no need for extraction) look into nurofen plus. you'll need far too many panadeine fortes to catch a good buzz, you won't be doing yourself any favours by taking 3g+ paracetamol.

 

[nephron]

Don't take more than 4g in a day, and take that in divided doses. Anything more is asking for liver trouble.

 

[fastandbulbous]

Yeah, methionine (and cysteine) are metabolic precursors of glutathione, and the liver combines glutathione with the paracetamol metabolite in order to stop it being toxic. Thing is, the liver has a limited supply of glutathione, so anything over 4g depletes the liver. The above sulphur containing amino acids act as an immediate source for glutathione production.

One thing though, methionine only has a full antidote effect if taken within a few hours of the paracetamol (it's a longer metabolic route to glutathione from methionine than from cysteine), after that, acetylcysteine is the preferred treatment by A&E depts (it's also given IV for an even more rapid effect).

If you've had the troble you've mentioned in the past re people and paracetamol, it's not a bad idea to have some methionine in the house; I believe it's something like 300mg of methionine for every gram of paracetamol over 4g, but I'll ask my other half when she gets in from work (paracetamol OD's are the most common enquiry poisons units have to deal with, so she can recite the figures in her sleep)

if you want easy to get codeine (no need for extraction) look into nurofen plus

If you've got any sort of troble with your stomach, or are taking steroids (corticosteroids mainly), the ibuprofen in nurofen can make your stomach bleed like a stuck pig, so you have to be careful with them as well

 

[redeemer]

I can't understand why you don't just do the extraction. It would take a couple of minutes and you could avoid getting any degree of hepatoxicity.

 

[billbong]

Don't do it man

 

[DexterMeth]

if you want easy to get codeine (no need for extraction) look into nurofen plus

how much profen, MAX, in a 24hour period? Not the dr. reccomendation, but when it comes to abusing codiene/ib pills.

 

[K'dOUTinAZ]

Paracetamol is the same chemical as Acetaminophen and no more than 4000mg should be consumed within a 24 hour period to prevent liver toxicity.

 

[K'dOUTinAZ]

how much profen, MAX, in a 24hour period? Not the dr. reccomendation, but when it comes to abusing codiene/ib pills.

According to the PDR, you should not exceed 3200mg of Ibuprofen in a 24 hour period but personally I wouldn't recommend going above 2400mg.

 

[LIVE4EVER]

You think the chance of hepatic toxicity is that high, taking all that tylenol just once? Not that I'd advise people to do so, I've consumed much more than 4 grams of acetaminophen on numerous occasions. I haven't noticed any ill effects, but I have not had a liver profile lately, either. Kinda scares me.

 

[K'dOUTinAZ]

By taking 4 grams of acetaminophen? No, you will not experience liver toxicity by using 4 grams of acetaminophen all at once but over time it will.

 

[DexterMeth]

Profen..

Then wtf is fastandbulbous trying to spread here? I know he's not like that. But.....

"if you want easy to get codeine (no need for extraction) look into nurofen plus "

If the max daily amount for "fen" is even lower than "APAP", why would you ever even take fen over apap?

I must be missing something here. Perhaps there is hardly any fen in each pill compared to APAP or something.

 

[K'dOUTinAZ]

Products that contain Ibuprofen contain lower doses than Acetaminophen products. Example: Over the counter Tylenol contains 500mg of Acetaminophen and Motrin contains 200mg of Ibuprofen.

 

[nuke]

have taken 3500 mg paracetamol with a huge amount of whisky and I still live, dosed 7000 mg another time and still live...one of my friends had dosed about 10-15 grams of it as well and still lives (both suicide attempts, no medical interventional). Hmmm.

 

[K'dOUTinAZ]

I've dosed well above 4000mg on many occasions also. Shit, I've dosed more than your 7000mg of Acetaminophen also. It ain't going to kill you or permanently hurt your liver if you ingest over 4000mg of Acetaminophen in a 24 hour period. Its just not recommended to do so, especially over a prolonged period of time because eventually it will create liver toxicity.

 

[DexterMeth]

A couple weeks ago i dosed 9000mg APAP, 2 days in a row, twice in 1 week. My liver hurt like a mother for a day.

Havent taken any APAP since, and havent felt any pain since.