• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

What would be the hardest psychedelic drug to synthesize to date?

Visionary_Kpsycho

Visionary_Kpsycho

Bluelighter
Joined
Apr 18, 2007
Messages
428
Location
Eastern Canada
What I mean by hardest is, the amount of time, money, knowledge, and preparation involved in the process. Hopefully some of you can give some uncommon chemicals I haven’t heard of. This is strictly for discussion and by no means a drug synthesis thread.
 
I've heard Unobtainium can be psychedelic on skin contact.

Seriously though, this does seem like an interesting question for trivia's sake.
 
I was under the impression that any of the ergoline total syntheses were extremely difficult;
AFAIK ibogaine has no total synthesis and has to start from an akaloid already in the iboga plant (or nearby families)

Hyperforin looks like it'd be difficult
 
A chiral total synthesis of lagochiline would be pretty challenging, as it's got seven stereogenic centres. Not sure if it qualifies as psychedelic though, but definitely psychoactive. It's found in Lagochilus inebrians, which by the way has one of the coolest botanical names in existence. :)

The himbacine series of alkaloids from Galbulimima belgraveana aren't easy either, although most of them have been synthesised.
 
Total synthesis of ibogaine was accomplished many years ago. Modern total synthesis works with far more complex structures. Im still awaiting the total synthesis of maitotoxin :)

Yet I agree that total synthesis of iboga alkaloids such as voacamine (if it is indeed a psychedelic) would be quite an accomplishment for clandestine chemists :) Hyperforin and other alkaloids from st. johns wort look intriguing as well.

As for TCB-2, its not really that bad. I could think of a more elegant way of synthesizing the fused ring system. Which would perhaps increase the yield.
 
2C-A, obviously.

Where else can one go, from 2C-I? The iodine is the fourth, and the last of the so-called halogens, at the bottom of the classical periodic table. But, thanks to the miracles that have accompanied us into the nuclear age, there is a fifth halide now known, Astatine. All of its isotopes are radioactive, however, and it seems unlikely that there will ever be an entry (other than this one) for 2,5-dimethoxy-4-astatophenethylamine. What might be speculated as to its activity? Probably similar in potency to 2C-I, requiring maybe 10 or 20 milligrams. The duration would be dicey to measure, since the isotope with the longest known half-life is half decayed in about 8 hours, and the longest lived natural isotope (for those who insist on natural rather than man-made things) is half decayed in less than a minute. Two predictions would be pretty solid. You might have quite a job accumulating your 10 milligrams of Astatine, as the most that has so far been made at one time is only about 0.05 micrograms, approximately a millionth of the amount needed. And the second prediction? You would not survive the screaming radiation that would bombard you if you could get the needed 5 or 10 milligrams of radio-astatine onto that magic 4-position, and the resulting 2C-A into your tummy!
Click to expand...
 
Visionary_...
I am curious why you suggested this chemical (1-Aminomethyl-5-methoxyindane (AMMI)?
) as the hardest to synthesize, and you're the one who started the thread (Interestingly enough, a week after I created the AMMI thRead (below))

Please see my thread http://www.bluelight.ru/vb/threads/...MMI-)?highlight=1-Aminomethyl-5-methoxyindane and see if perhaps you can contribute to the discussion.

The topic has been mostly overlooked; i wonder if I had posted the thread on AMMI in ADD rather than OD, if it would get more attention as similar new RC's have in the past in ADD.

Thanks _VR
 
Sounds like a novel way to selectively destroy 5-HT receptors
Click to expand...

Nah, the molecule will damage whatever it happens to be near when the astatine goes poof. Odds are that any given atom won't be bound or near a 5HT2a receptor when it goes, so they should be fine.

Question: Were such a molecule synthesized, would the molecule remain intact after decay? Would whether it went via beta or alpha decay? I don't see anyone wanting 2C-Bismuth (or 2C-Polonium for that matter!)... ;)
 
Considering that the only naturally occuring isotope of bismuth other than those occuring as daughter nuclides from radioactive decay has a half life, according to wikipedia of a billion times the age of the universe, I wouldn't be too worried about radiation poisoning from 2C-Bi, considering also that the user of the drug would have decayed long before the Bi content ever did:P
 
Limpet_Chicken said:
bismuth ... has a half life of a billion times the age of the universe
Click to expand...

i never knew that before

do you think the property that makes bismuth so stable is also the property that makes bismuth crystals look so cool?

b-454197-bismuth_crystal.jpg
 
nAON said:
Are there any threads on psych peptides? Was something I was looking to read up on, and BL search is a clusterfuck
Click to expand...
The only "psychedelic" peptide I remember reading about personally was actually aimed at being a potential clotting agent, but research was discontinued when the rats started tripping out/ showing vary weird rat behavior.

Its interesting that so many potentially amazing CNS targets end up having massive effects on the vascular systems.
 
Half-life aside, would the synthesis itself of 2C-A be very difficult? I wouldn't imagine it's any more difficult than the other 2C-halide series.
 
You must log in or register to reply here.
Top