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What potential does DMSO have then?

O

ooccooccoo

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I recently bought half a litre of the stuff and am going to have a mess about with it.

Was just wondering if anyone had any advice or experience with what works and what doesn't.

I'm particularly interested in absorption through the skin, and the potential to put various RC's into liquid form as quite a few don't seem to dissolve into ethanol too well. Ketamine muscle rub? Liquid DOC? Seems interesting anyway, no need for needles or ragging your nose.

So any pointers on what is likely to dissolve well and work through the skin might save me time and money! And if people are interested I'll post results of testing it out. Have searched but haven't found any proper discussions on it.
 
Yes it dissolves various things pretty well. I know of someone that dissolved a WIN cannabinoid RC in DMSO and applied it to stomach, stonedness resulted, but so did a red patch of skin irritation. DMSO apparently also gives your breath a nasty garlic scent for a day after use.
 
I know of someone who was planning a K waterpistol trick at Dance Valley, but I don't know if they ever did it. I've seen foxy methoxy in DMSO before now.
 
DMSO experiment number 1:

About 8 days ago I dissolved 25mg of 2cb in 1ml of 99.7% pure DMSO. It dissolved pretty much instantly, so probably could have used less solvent.

Unsure about where to apply it, I decided my forearm would be best (can see a lot of veins was my logic...I'm no biologist).

I rubbed it into my arms but 1ml proved a fair amount. You could see the DMSO evaporating into the air like steam or something. My arms began to tingle and feel slightly tight and I felt like I was coming up slightly...a bit tense/nervous/tingly buzz...but never got any visuals, maybe colours seemed a little brighter? Could all just be placebo though.

An hour or so later on, still feeling slightly odd (but no where the usual effect eating 25mg would have one me) a couple of mates and I decided to go to the park and I did a line mixed with cocaine. I have no idea how much 2CB was in the line but I came up really hard, not sure if it was just a big line or the amount already in my system from the DMSO 'boosted' it.

I think I might try it again but this time put the solution in a shot glass and hold it upside down on the skin so the DMSO has no choice but to absorb in. Also, does anyone know if it might just not work with phenethylamines and I'm wasting my time?
 
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DMSO experiment number 2:

One thing I'd been contemplating for a while is a way of getting liquid 2CB/2CI etc. to save weighing out doses every time some is wanted, and messing about with capsules.

I've been given a gram 2CI in alcohol, possible vodka (not pure ethanol) and it didn't dissolve very well - the bottle needed to be shaken cos of 2CI sediment at the bottom came out in clumps and the dose was pretty random. My thinking is that DMSO would be a better solvent and smaller amounts would be needed, maybe get it to 10mg a drop?

To test, I eyeballed out a dose of 2CB and put it in some DMSO (too much), and left it over night, covered to prevent evaporation. This was in order to see if the solvent degrades the quality of the 2CB over time. My friend ate it next night and reckoned it still worked completely fine but it fucked with his stomach when 2CB doesn't normally.

I think next step is to put some 2CB in a dropper bottle and add drops of DMSO until it's totally dissolved (therefore the minimum amount needed), count the drops and work out the mg to drop ratio to see if its worth it. Also would be interesting with DOC/I etc. 1mg per drop would make dosage a lot easier...currently have some half dissolved in vodka where 0.5ml is 1mg.
 
This topic is very dear to my heart, and you have a thread stalker from this point onward.

I should begin by saying my knowledge is in Steroids and transdermal delivery with DMSO and other solvents. I won't begin to speculate on your 2cx transdermal delivery. I will ask however the mollecular mass and general polarity of such compounds. I am assuming it is rather non-polar considering your attemps to dissolve it in alcohol. Luckily DMSO seems to dissolve anything =D .

Its a very usefull compound, I too have spent some time experimenting with the solvent. I would like to spend some time with some hash oil, 50:50 DMSO: Isopropyl/ethyl mix.

I once tried to use some cannibus alcohol extract+DMSO that gave me a nasty rash in the spot I tested it. Needless the say I didnt proceed to phase 2 of testing.;)
 
giantsquid said:
common mate, dont let the facts detract from a great story ha ha ha :)
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Well, for harm reduction, a drop is not going to dispense the same amount of liquid every time. This could be a potential disaster for chemicals like the DOxs.
 
samadhi_smiles said:
A 'drop' is not an even unit of measure.
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true it isn't a unit of measure but......
In my experience with pure water 1 drop forming at low presure and turbulence is almost always 0.1 ml don't ask me exactly why. it has to do with surface tension any bigger and it splits into several drops. at higher pressure and higher turbulence then much smaller drops can be made.

with other solvents and detergents and dissolved substances other things happen.
so don't use it for dispensing potent things
V
 
DMSO can also be mixed with a less agressive solvent to get stuff to dissolve, the mixed solvent is almost always better than the two separately. the DMSO through unbroken skin thing is pretty poor, the earliest original research came from the canadians who were using it mixed with VX nerve gas, which incidentally can penetrate the skin pretty well, anyway VX and DMSO was twice as effective as VX alone. various shady men in black types have tried LSD in DMSO and DMF BZ in DMSO and oxotremorine in DMSO the latter was from what I have heard the only effective one, but hardly a fun substance.
the rules seem to be the smaller the molecular weight the better a molecular weight of 400 or less seems important, and the substance should be fairly lipid soluble, the terpenes in lemon rind do dissolve and do penetrate. but on the whole it is a pretty poor delivery method.
V
 
I was wondering what would happen if you took a water balloon full of DMSO and ethanol and threw it at someone.
 
wungchow said:
I was wondering what would happen if you took a water balloon full of DMSO and ethanol and threw it at someone.
Click to expand...

you would get a broken nose :)
 
Pure DMSO doesn't give that garlic effect; it oxidizes rapidly in sun light. Fresh DMSO has essentially no smell at all.

I've messed with trandermal DMSO. I think it's electric cool aid acid test that says as soon as you rub some on your skin you can taste it. What a load of shit that is.

I have tried it to transdermally apply numerous drugs and have had fuck all success;

It's a great solvent though, and after you have dissolved drugs in DMSO, you can then put the DMSO into water or ethanol, and 99.9% of the time the drug will stay in sollution, so if you're planning oral use, that's a good way to go.

Re water drops: You get smaller drops if the circumference of your dropper tube is smaller (needle vs eye dropper). Water droplets in my experience can be anywhere from .1 mL to .7mL.

(Edit, I meant, from .01 to .07...

(And I was wrong about that too. See post)
 
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Other transdermal delivery enhancers include:
IPM- Isopropyl myristate
OA- Oleic Acid
PG- Propylene glycol
D-limonene (some consider this an enhancer some say it is just used in mixes to cover the smell of the DMSO)
DMSO- Dimethyl Sulfoxide

And I will second the info about a mollecular weight of less than 350-400 is optimal. Less polar compounds seem to diffuse more readily accross the skin.

And if your breath didnt smell like DMSO after application you didnt use enough. Because I assure you... you can taste it....
 
BigBenn said:
And if your breath didnt smell like DMSO after application you didnt use enough. Because I assure you... you can taste it....
Click to expand...

I used enough tomake surethe 2cb was well dissolved.

My mate put a gram in a dropper bottle and added DMSO until it was all dissolved, counting the drops so we could work out how many mg per drop. People didn't like the drops, they burnt their tongues apparently.

Don't think liquid 2cx is achievable just yet but I'm no chemist!
 
i dont know why people really care about transdermal anyway, its unlikely to be an especially fast method of administration compaired to any others, the only advantage i can think of is it can be used for sustained release. i have also experimented with DMSO, the only promising idea i have had so far was the combination of sublingual administration and dmso, because it would enter the blood stream quickly, eliminate the need for needles and might even overcome some of the mono amine oxidase issues that drugs like DPT and DMT have orally.

best ideas i have had so far are oral salvinorin-A in DMSO solution, could be incredibly potent (as potent as smoking prehaps) and with a much longer duration, giveing the user proper ammounts of time to explore salvia space.

also DMT in dmso sublingually, or a combination of dropping a lower dose of any given drug combined with DMSO up the nose. i find just the simple act of making a powder a liquid before snorting it make it much more potent, i dont know if anyone here has done a line of coke, waited till you were coming down a little, snorted a bunch of water and gotten a second rush.
 
You guys seem a lot more clued up about all this and I which is useful - I'm just going by hear'say.

So...let's say I wanted to make liquid 2CB/2CI/2CE etc.....what would be the best way? My friend tried it with B and DMSO and it didn't seem too popular - burning tongue sensation.

I had 2CI in alcohol (don't know if it was pure ethanol or just a strong spirit for drinking) and it didn't dissolve properly, so even after shaking dosage was pretty random.

I had DOB in liquid form last year and 1 drop (out of one of those brown dropper bottles you get from chemists) was ~1mg but I haven't the foggiest what it was in. I have some DOC and DOI and tried disolving these in vodka and they didn't dissolve fully. Worked out 0.5ml was 1mg (I put 100mg into one of those little 50ml spirit bottles you usually get on planes), and even then I had to shake it a bit and could see bits floating around, andthen mess about with the syringe to make sure the dosage was accurate. This seems to have worked fine but is impractical.

I am just sick of capsules and syringes (for measuring, not injecting) and would much rather just be able to drop it like liquid acid.

Cheers for the help guys.
 
If you look at "Physical Chemistry" by W.J. Moore, 4th edition, page 257, you'll
see a phase diagram for nicotine + water. It shows a large two phase region
above 60 C extending from ~5% to 80% weight % nicotine. This suggests that steam distillation can be used to obtain a pure product. Others might suggest
extraction with an organic solvent. The problem is that such an extract would
require a purification step. Many low molecular weight oils which are insoluble
in water can be obtained in nearly pure form via steam distillation. Steam
distillation works well with low molecular weight amines when the still pot is
made basic with hydroxide. Addition of base might be helpful in steam distillation of nicotine. Sorry I can't supply a documented procedure on short notice.

DMSO will dissolve just about anything and certainly tetrahydracannabinol, caffeine and nicotine. DMSO is well know for its ability to carry solutes through the skin.
 
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