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Stimulants What kinds of drugs are stronger then methamphetamine?

rocketqueen said:
@THC2LSD, quite right, quite right, NOTHING rivals IV cocaine as far as INTENSITY - a banger of coke will straighten your hair if it is curly. Meth for EUPHORIA, or sense of well being if you like that better.
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ya know... never done meth, let alone IV, but done most other things via that route. IV cocaine is indeed intense, but I find the effects far too short to really enjoy without shortly wanting another shot. Plus, the danger associated, and the frequency of IV dosing, it just makes it not really viable for a recreational ROA of the drug, even less so for a self medicating type of usage.
 
Methamphetamine releases a lot of dopamine. As others have said, MDPV is a reuptake inhibitor. While it increases dopamine levels, it does it in a different way than methamphetamine (or regular amphetamine/dexamphetamine) does. Cocaine, Wellbutrin, Ritalin (methylphenidate) and Strattera are other examples of reuptake inhibitors. (These drugs work on neurotransmitters other than dopamine as well - just like methamphetamine does).

It is important to know the different between dopamine releasers (such as the amphetamines) and dopamine reuptake inhibitors.
 
NT - so what would happen if one combined a dopamine releaser (such as dextro-amp) with a dopamine reuptake inhibitor (say, cocaine)? Common sense would say that they're magnify each other, but common sense has misled me before...
 
Hmmm, yea, that is what I gathered from the wiki page. Strange, but I guess theoretically it would certainly make sense. As I said, common sense has failed me before. Thanks NT.
 
It sucks mixing meth and coke. You get the body load of both without any increase in euphoria. You'd think since mixing downers makes them better(subjectively) that mix upper would have synergy too, but coke and amphetamines including MDMA seems to counteract each other.
 
trocious said:
ya know... never done meth, let alone IV, but done most other things via that route. IV cocaine is indeed intense, but I find the effects far too short to really enjoy without shortly wanting another shot. Plus, the danger associated, and the frequency of IV dosing, it just makes it not really viable for a recreational ROA of the drug, even less so for a self medicating type of usage.
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@Trocious, I don't fix up or fuck with coke at all anymore PERIOD. The come down is brutal, so brutal that the high is not worth it for me. I suffer from wicked bad depression, so I figured that the comedown for me is even worse than it would be for a "normal" person.

Plus, have to inject oneself repeatedly gets real freakin' old. Banging coke is not a good time, it is an obsession. And seeing people do it, shaking, sweating, working their jaw...it is too much.

Moreover, after runs my arms looked like they went through a garbage disposal. Pathetic. Coke SUCKS - FUCK THAT SHIT.
 
In my opinion MDPV in a pure form or even 4-fa or mephedrone might be STRONGER...but GOOD QUALTIY ( and i stress that) meth lasts very long and in my opinion is more euphoric (during the first 6-8 hours which is pretty fucking long) than the others listed.

This is all in terms of dopamine and serotonin release of course.
 
4 FA has a tweaky edge to it, um &, sleeping & eating are difficult while still under it's effects. I personally would like to try aPVP, it's very close in structure to MDPV, although thats one I never tried & probably wont get to.
 
IV meth is pretty intense but IV coke is just as intense, just shorter. never tried mdpv but hear that makes meth look like caffeine. mephedrone is probably up there too.
 
Well its not all about the dopamine brah. There is tons of other stuff involved in stimulant "euphoria" other than RELEASE ALL THE MONOAMINES, things like mu opioid receptors, more than a handful of 5HT receptors, all sorts of glutamate receptors, and random barely understood stuff like NAChR and TAAR agonism. Meth is pretty much the most dopamine you can squeeze out of yur neurons without going into some very, very obscure compounds that don't need to see the light of day (think horrific long term side effects that make meth look like ritalin).

But, pop some low dose opioids, take a SMALL amount of curcumin, or take some low dose 5HT2A agonists and see what happens. Gotta love fucking around with your brain's reward pathways, but play safe man.

Also, 4-methyl aminorex raises serious concerns with me due to heart valve changes with similar drugs in its class.
 
Oh dude... 4-methyl aminorex is the only stimulant I will ever bother to use these days...

I can see why it would raise those concerns ha.
 
4-MAR sounds to be the most powerful stimulant there is. Extremely long lasting meth+mdma basically, damn. Not sure if I even wanted such long duration (anecdotally 30 hours from huge oral dose). But I think most people don't mind longer duration so I wonder why it never became very popular? I think its basically impossible to get here, despite being half a century old, at least I never heard about it.
 
I would NEVER want to try 4-MAR. That is ALLLLLLLL bad news. Even though it sounds like it would be right up my alley, with the name Euphoria and all. But noooo way, even I know not to do that.
 
Lol it's just probably TOO good and so certain way to destruction. I don't want it either.
 
As far as stimulants go, there is nothing stronger than racemic methamphetamine. Not amphetamine (comes close though), and definitely not methylphenidate. 4-Methylaminorex also comes close, but still not stronger.

Very high grade cocaine can come very close, but it just doesn't last long enough. Methamphetamine cannot be topped.
 
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