what is your guyses obscure but underrated drug no one talks about

[emkee_reinvented]

has anyone ever actually done jenkem and if your not fucking with me why not just do freakin gasoline or something its probably even easier to source than days of shitting and pissing

Inhaling fart s yes under my blanket.

Serious fresh Khat/ Catha-Edulis, in a nice Banana leaf wrap.
Washed down with White Tea, or Yellow. Or your preferred Cola brand.
Never took it without a methyl-Xanthine.

The way it should be consumed according to the vendor. Synergie.
No NRG-drinks or Coffee and no Booze.

The fibrous residue after chewing you discard, a hour in it should be working.
Taken up sublingual to so noticeable faster. A unique high.

 

[shreddedlettuce]

Serious fresh Khat/ Catha-Edulis, in a nice Banana leaf wrap.

Probably the best answer to this thread so far.

but the "fart" suggestion lost you points.

 

[dopamimetic]

4,4'-dimethylaminoex. Boss level empathogen on which you can roll for multiple days in a row with little repercussions. And its lil cousin 4-MAR which I haven't been able to source yet.

 

[TheLightBringer]

Well it's pretty obscure so not many people. For the people who don't they either assume it's weak, have a high tolerance so it's ineffective or don't even know it exists.


Reports on it do exist.


reddit.com/r/gabagoodness/comments/o51plu/does_agmatine_have_any_recreational_properties_or/


reddit.com/r/Kanna/comments/18qr34z/how_to_smoothen_the_rush_agmatine_sulfate/


reddit.com/r/Marijuana/comments/zt0afy/agmatine_sulphate_supplement_cannabis_wow/


reddit.com/r/Nootropics/comments/7t5779/agmatine_metamorphosis/

Yes I am well aware of the pharmacology of agmatine and its ability to lower tolerance and potentiate other substances, the fallacy lies in that the majority of reports mention combining it with another substances and said it made them high. We have human studies going up to 3,5g agmatine per day, mentioning anti-depressant effects and reduction in neuropathic pain, and there are probably hundreds of thousands of people who have taken PWOs with agmatine commonly dosed between 1 - 2g. None of these are mentioning a narcotic ketamine like effect. Im saying people who claim they feel high from 250mg agmatine are almost certainly experiencing placebo.


Citral is also a common food additive, I sincerely doubt its significantly psychoactive. While it is true that it potentiates barbiturates, has psychoactive and motor-relaxant effects things like L-theanine also have a synergistic effects with depressants. Yet no one gets ”high” from something like L-theanine

---

In this study, we have investigated the possible antidepressant-like effect of scopoletin
...
The results indicate that its antidepressant-like effect is dependent on the serotonergic (5-HT2A receptors), noradrenergic (α1- and α2-adrenoceptors) and dopaminergic (dopamine D1 and D2 receptors) systems.
— https://doi.org/10.1016/j.ejphar.2010.06.043

---

This study is interesting though, thank you for providing. It is in mice and failed a lot of the non stressed tests but I believe now that it likely could have interaction with the 5HT2A receptors.

Doesnt really provide any evidence to it being strong enough to be a psychedelic though but id bet you could get some sort of psychoactive shift if you megadosed it.

 

[Allylbenzene]

None of these are mentioning a narcotic ketamine like effect.

That's because it's not really like ketamine, it just shares similar properties.

Im saying people who claim they feel high from 250mg agmatine are almost certainly experiencing placebo.

I get where you're coming from but you can't make assumptions about peoples subjective experiences. I can discern low-doses of agmatine but someone else can't. This is just different body chemistry.

Citral is also a common food additive, I sincerely doubt its significantly psychoactive.

It's ok stand-alone but better when used in synergistic combos.

While it is true that it potentiates barbiturates, has psychoactive and motor-relaxant effects things like L-theanine also have a synergistic effects with depressants. Yet no one gets ”high” from something like L-theanine

Theanine is another useful psychoactive, works well standalone or in combos.

Doesnt really provide any evidence to it being strong enough to be a psychedelic though but id bet you could get some sort of psychoactive shift if you megadosed it.

You don't need megadoses. If you only look for evidence in studies you will miss 50% of what's out there.

 

[Keif' Richards]

Oh my god, Bupropion (Wellbutrin) is the worst. It tends to produce compulsive, binge patterns of usage combined with the heightened probability of seizure the higher the dosages are raised. I´m going to move this one to Drug Culture as it´ś more of a curiosity issue, as opposed to directly related to the safety of our members.

BDD->DC

 

[TheLightBringer]

You don't need megadoses. If you only look for evidence in studies you will miss 50% of what's out there.

I agree with you on that but I think the large majority of good plant psychoactives have already been discovered. Its unlikely we will discover some new ground breaking recreational plant drug

Why use inferior compounds with a so called ”dirty” pharmacological action

 

[Allylbenzene]

I agree with you on that but I think the large majority of good plant psychoactives have already been discovered. Its unlikely we will discover some new ground breaking recreational plant drug

You'd be surprised what's still undiscovered.

 

[Shinji Ikari]

BK-MDMA

The duration was shorter and it could be a bit crashy as it wore off pretty abruptly but fuck me what a drug. Lot of fond memories from the year before it was banned. In fact circa 2009-10 the majority of what was being sold as MDMA in my parts was actually methylone owing to the saffrole ban. I remember an occasion around 2010 when a friend gave me what they called "the best MDMA they'd every had" which I instantly recognised as methylone because I'd been taking it twice a week for the last year.

Good shit. No idea why a clandestine market for methylone never emerged while other cathinones stood the test of time (mephedrone for example), because MDMA became available again I suppose but I miss it dearly.

Edit: SPAG

 

[KurtAurelius]

Yes I am well aware of the pharmacology of agmatine and its ability to lower tolerance and potentiate other substances, the fallacy lies in that the majority of reports mention combining it with another substances and said it made them high. We have human studies going up to 3,5g agmatine per day, mentioning anti-depressant effects and reduction in neuropathic pain, and there are probably hundreds of thousands of people who have taken PWOs with agmatine commonly dosed between 1 - 2g. None of these are mentioning a narcotic ketamine like effect. Im saying people who claim they feel high from 250mg agmatine are almost certainly experiencing placebo.


Citral is also a common food additive, I sincerely doubt its significantly psychoactive. While it is true that it potentiates barbiturates, has psychoactive and motor-relaxant effects things like L-theanine also have a synergistic effects with depressants. Yet no one gets ”high” from something like L-theanine

---

In this study, we have investigated the possible antidepressant-like effect of scopoletin
...
The results indicate that its antidepressant-like effect is dependent on the serotonergic (5-HT2A receptors), noradrenergic (α1- and α2-adrenoceptors) and dopaminergic (dopamine D1 and D2 receptors) systems.
— https://doi.org/10.1016/j.ejphar.2010.06.043

---

This study is interesting though, thank you for providing. It is in mice and failed a lot of the non stressed tests but I believe now that it likely could have interaction with the 5HT2A receptors.

Doesnt really provide any evidence to it being strong enough to be a psychedelic though but id bet you could get some sort of psychoactive shift if you megadosed it.

I take 3 grams a day. It’s not crazily psychoactive but with someone with a lot of mental illness and anxiety etc, I feel like I’ve woken up when I’ve taken it. My mind is clear and my body feels floaty like very low dose ketamine.

All drug, food and other cravings gone, and I feel comfortable in my body but able to actually let go of being in a experience rather than my usual focus of how uncomfortable I feel.

I’m extremely sensitive to anything I take so that’s a caveat

^ theanine also psychoactive but much more so if stacked with similar agents.

 

[KurtAurelius]

Methylphenidate.

I’ve only tried Methylphenidate but it’s my favourite stimulant and I’m reluctant to go any further as logic pushes itd be a unwise choice.

If it stops working, going further doesn’t seem to outweigh the benefit (I.e going super high dose like past 60mg, or going on DextroAmp)

In the UK it’s Methylphenidate, Lisdex/Dexamp, Atomoexatine or Guafacine only with GP approval.

I pick Methylphenidate, the way it soothes all drug, sex, binge eating and other cravings is a life saver for me.

Theoretically there is a more perfect drug, or more yet a effective set of parameters to obtain the conditions methylphenidate sets for all the issues I face.

I’d ask for Isopropylphenidate but Methylphenidate is the next best bet.

But with its relatively clean pharmacology to a uneducated “reader” it appeals, as well as its tolerability for me, and its short half life.

I can only live to my almost perfect requirements by being extremely lonely and living to a spreadsheet due to the prevalence of my autism and adhd, methylphenidate just makes it so much easier.

There is a cost but although no calculation is perfect, it gets to a point where you push for a bit, back off, reassess and see if you can still get use out of a substance.

I have to take around 10mg every 4 hours for up to 12 hours of the day or similar to get what I need out of it.

Compared to using DextroAmp, that’s preferable. The research is so so but I’m more invested in Methylphenidate being the safer bet with only losing a bit of effectiveness. I get it doesn’t work for some but how many of them do a full body workout, walk 10km a day, get sunlight, and eat whole food diet.

That’s how you get the most of the drug + being clever with synergistic agents (Theanine, Magnesium Threonate, Taurine, Agmatine, Creatine, + things like L- Citruline for Blood Pressue etc)

Mostly Out of my system overnight, no active metabolites, a much gentler way of releasing monamines and easy to discontinue relatively (need replacement but dropping down to only caffeine and being basically fine is pretty cool)

I can do it without, but I’ve come to conclusion that if it really helps and can be made practical then it may bring a better quality of life. I know it has for me.