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Misc What is your favorite antihistamine?

A

adicted

Bluelighter
Joined
Apr 24, 2012
Messages
52
The first-generation antihistamines have a sedative effect that can be used to induce sleep or to enhance tranquilizers or opiates / opioids.

The most important are diphenhydramine, dimenhydrinate, doxylamine, promethazine and hydroxyzine.

In Spain these antihistamines are available without prescription except promethazine prescription required (although I try to buy without prescription). Hydroxyzine prescription required but whenever they ask me the counter in all pharmacies, in practice as if it were OTC.

Diphenhydramine is marketed under the name Soñodor, sold as OTC sleep-aid and are 50 mg tablets. diphenhydramine.

Dimenhydrinate is marketed under the name Biodramina for motion sickness and comes in 50 mg tablets., Gums 20 mg. and suppositories of 50 mg. and 100 mg.

Doxylamine is marketed with names like Dormidina and Normodorm OTC sleep-aid and comes in 25 mg tablets.

Promethazine is marketed under the name Frinova to treat allergy and nausea and is marketed in liquid solution of 50 mg. / 2 ml.

My favorite is doxylamine, with one tablet of 25 mg. get a powerful sedative effect. I have not tried promethazine

Among diphenhydramine, dimenhydrinate, doxylamine, promethazine and hydroxyzine, what is your favorite?
 
I take diphenhydramine for sleep sometimes,

but as a potentiator I think hydroxyzine or promethazine is best.

Those aren't OTC for me though.

Doxylamine is too short acting for me.

Don't forget phenyltoloxamine! Best OTC (antihistamine class) potentiator in USA, sometimes hard to find offline though.
 
omen_owen mk2 said:
At the moment I'm using promethazine, no prescription needed here.
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You can explain me how is the effect of prometazine? I know that in USA in the field of hip-hop is widespread custom of combining codeine with promethazine and Seven Up in a famous drink. Do you have promethazine tablets or liquid?

N0 W4RN1NG said:
I take diphenhydramine for sleep sometimes,

but as a potentiator I think hydroxyzine or promethazine is best.

Those aren't OTC for me though.

Doxylamine is too short acting for me.

Don't forget phenyltoloxamine! Best OTC (antihistamine class) potentiator in USA, sometimes hard to find offline though.
Click to expand...


I'm surprised you say that doxylamine is too short action for you. In Spain the best known trademark of doxylamine as OTC sleep-aid is Dormidina and prospectus says that if you take it you must make sure that can sleep eight hours because if you wake up before you'll with residual sedation. And many people taking doxylamine as OTC sleep-aid complains that rises in the morning still sedated by doxylamine. The sedative effect of a dose of 25 mg. doxylamine takes about 8-10 hours. At least as hydrogensuccinate.

I can buy without prescription all hydroxyzine I want (50 tablets of 25 mg. by 3.5 euros) and I have taken many times hydroxyzine and doxylamine and in my opinion doxylamine is more sedating than hydroxyzine at the doses indicated in the prospectus.

I prefer doxylamine to sleep. Diphenhydramine takes a long time to fall you asleep and is a natural-like sleeping, but doxylamine in 30 minutes leaves you KO.

Doxylamine in my opinion is the best as sleep-aid so as to boost (I have not yet tried promethazine)

I can freely purchase hydroxyzine, doxylamine, diphenhydramine and dimenhydrinate. Next week I'll try with promethazine.
 
LOL at the field of hip hop.

I don't really like these threads, and I don't think there generally allowed, but diphenhydramine is the best overall anti-histamine, especially for daily use(I need take them everyday).

Doxylamine is a surprisingly good hypnotic if used occasionally.

Hydroxyzine and promethazine are the most powerful, and likely preferred by many opioid users, but in the US they are POM. Promethazine itself is amazingly potent, and has a long half-life.

However, I still say the original is the best-diphenhydramine, for all purposes is the most practical, and effective 1st gen antihistamine. But hydroxyzine is a great alternative if you can get it, since it is the only one that isn't also a potent anticholinergic.

(Pro methadone especially is terrible in this regard)

And I'm pretty sure there is an AH megathread.
 
I personally love hydroxyzine. I take 100mg when I am anxious, isn't euphoric like a benzo but it definitely takes the edge off. Also helps with sleep. I am not sure if it has any recreational value but it is definitely a nice potentiator when it comes to opiates/opioids and Kratom.
 
Promethazine, unless I'm using codeine, in which case, doxylamine (promethazine slightly inhibits the metabolisms of codeine into it's active metabolites). Only for opioid nausea/itching - taking high enough doses for sleep makes me feel awful.
 
Okay serious post here...

Will taking hydroxyzine with diazepam cause any issue? Is it useful, any advice is appreciated.

Thank you.
 
Rybee said:
Cetirizine.

Works a treat for my allergies.
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Yes, cetirizine is an excellent 2nd generation anti-histamine. It is great for allergies, and has a long duration.(And a very high binding affinity, for whatever that's worth.)

However, the OP was talking about 1st gen anti-histamines. But what I like about cetirizine is that, in high doses, it does penetrate the CNS and indeed does act as a 1st gen anti-histamine at higher doses.

(The difference between the two being that 1st gen readily cross the BBB, but 2nd generations only poorly penetrate, at the recommended doses, that is.)
 
Crankinit said:
Promethazine, unless I'm using codeine, in which case, doxylamine (promethazine slightly inhibits the metabolisms of codeine into it's active metabolites). Only for opioid nausea/itching - taking high enough doses for sleep makes me feel awful.
Click to expand...

There isn't much solid evidence for that. I mean diphenhydramine is indeed a CYP2D6 inhibitor, but is so mild that with acute use it makes no practical difference with codiene/tramadol metabolism.

I suspect promethazine is the same way, only an effective inhibitor with repeated doses, however, it is always optimal to avoid 2D6 inhibitors with the pro-drugs, if at all possible. :)
 
Promethazine always significantly shortens and hinders my Codeine buzz, doesn't matter if I take it an hour before, after or at the same time with the goodies. Which makes me jelly of all the people that say it potentiates it.
 
Yeah, like I said, you should always avoid 2D6 inhibitors with pro-drugs, if possible(in some cases though all you'll have is diphenhydramine).

however, a lot of people swear by codeine/promethazine.
Including those in the "field of hip-hop"!
 
adicted said:
You can explain me how is the effect of prometazine? I know that in USA in the field of hip-hop is widespread custom of combining codeine with promethazine and Seven Up in a famous drink. Do you have promethazine tablets or liquid?
Click to expand...

It makes you a tiny bit sleepy, that's about it. Maybe it's half-good as an anti-histamine but I don't know because I've never used it as such.

You can buy it in 20mg pills by the brand name of Sominex or 10mg/25mg pills under the name Phergan. I believe it's also possible to get a low strength Phenergan elixr for kids.
 
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