I’d like to return to a question I’ve harbored a long time now that some chemists are active in the tread. From my reading, the main hypothesis regarding what causes this MehDMA appears to be that it’s due to some synthesis byproduct which may be related to either bad starting material; bad synth or a combination thereof. Though I’ve never been able to let go of the isomer hypothesis.
So I’d like to ask anyone of you knowledgeable chemists (Locking at for example unodelacosa & vash445) say if any of the 6 mass equivalent isomer of MDMA below can be made with a different precursor than what’s used to produce MDMA? A precusor that's not controlled?
2,3-MDMA
2-(3-methoxyphenyl)-N-methyl-3-butanamine
2-(4-methoxyphenyl)-N-methyl-3-butanamine
p-ethoxymethamphetamine
p-methoxy-m-methylmethamphetamine
2-(2-methoxyphenyl)-N-methyl-3-butanamine
(Pictures and information regarding identification of the above mentioned molecules here:
https://www.researchgate.net/public...d_isobaric_substances_using_fast_LC-ESI-MS-MS)
And 2 more general questions:
Does anyone know anything about the effects of any of these isomers?
Anyone has any idea of how to get anyone to do an analysis of some tested MehDMA as described in the paper above?
2,3-(methylenedioxy)cinnamic acid(CAS#:38489-70-2)
Or
2,3-(Methylenedioxy)benzaldehyde for the first one of the top of my head.im sure I could think of something better bet eh plug whatever chem you want in sigma or caymen and see what pop ups. You get to learn a lot of different stuff you weren't thinking of before
The meth equivalent i believe has been talked on different threads. by
AlsoTapered ive been lazy to look at the molecule but
"I'm going to suggest 'butylamphetamine' is most likely:
2-Methylamino-1-phenylbutane | C11H17N | CID 551747 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
pubchem.ncbi.nlm.nih.gov
Above is also the likely synthesis. While PMK is a controlled precursor, PEK is not. The reason is that when the chain of amphetamine (alpha methyl phenylethylamine) is lengthened to aephetamine (alpha ethyl phenylethylamine) the product has almost no DAT activity. It's more or less a selective to NET so no euphoric, just increases levels of adrenaline and produces nasty effects.
There are other possible positional isomers, in fact I've previously mentioned them but they all result in 4 isomers rather than 2 so unless one is prepared to lose 75% of the product to get to the 'good' isomer, it's not very likely.
People could sell PEK as PMK, mix the two or just label PEK as PMK. It's a subtle change and not on that the average Mexican 'cook' is going to notice. The smell would be a give-away, I suspect.
But it's not like it hasn't been explored. It's just not been adopted because it produces junk.
I'm pretty sure a 'unique impurity' was spotted in Russian-made BMK and it was para-tert-butyl BMK. My only suggestion for that was the BMK synthesis proceeding via a Grignard using phenylacetonitrile and MTBE being the solvent. If their was trace tert butyl alcohol... that could react with the Cl-... or something!
MTBE is used to increase the octane-rating of gasoline but I have noted that it turns up as a solvent in quite a few Russian papers and patents where one might more rightly expect diethyl ether or THF. Why the Russians use it I do not know. My suspicion is cost."
2-(3-methoxyphenyl)-N-methyl-3-butanamine
2-(4-methoxyphenyl)-N-methyl-3-butanamine
MAMDPA; MDMAPA; methyl 3-oxo-2-(3,4- methylenedioxyphenyl)butanoate. MAPA MD twin cousin
There is already MGPA, which is the 4 phenylbutyrate, instead of the 2 phenylbutryate, so I assume there will be a MD version soon, as well as an ethyl version of MDMAPA
I mean if Butanoic acid and methylamine give a condensation reaction with each other to produce N-methylbutanamide and water as the products.
C3H7COOH + CH3NH2 = C3H7CONHCH3 + H2O Carboxylic acids (such as Butanoic acid) can react with primary or secondary amines (methylamine is a primary amine) in a CONDENSATION reaction. This particular one is called Amidization. Water is made, and the OH of the carboxylic acid is replaced with the amine molecule (less one H). But this is outside my wheel house so if I'm wrong I'm wrong
More can be found here?
Studies on the Ring Isomers of N-Methyl-2-Methoxyphenyl-3-Butanamines (MPBA) Related to 3 4-MDMA
Also. These MPBA isomers would possibly appear as clandestine drug samples only by direct chemical synthesis and are not likely to occur as impurities of common synthetic routes for the preparation of MDMA.
Compounds 1–3 were prepared by the same general procedure using the appropriately substituted methoxyphenylacetone. The reaction mixture was refluxed and The solvent was evaporated to yield yellow oil 2-(methoxyphenyl)-3-butanone purified by vacuum distillation. The ketones were converted to the desired amines via reductive amination (3).
The methods for the preparation of the 2,3- and 3,4-MDMAhave been described in previousreports(1,3). The general procedure for the synthesis of these compounds begins with theappropriate aldehyde, 2,3-methylenedioxybenzaldehyde and 3,4-methylenedioxy-benzaldehyde (piperonal), as starting materials.The preparation of 2,3-methylenedioxybenzaldehyde has been reported previously (1,8).
Anyone has any idea of how to get anyone to do an analysis of some tested MehDMA as described in the paper above?
www.ncbi.nlm.nih.gov
