Overdose of 5-MeO-AMT - Approximately 60mg... Short story - my buddy told me if I didn't quit doing it, he would not be my friend anymore. So what did I do? Dumped the last of my vial in my mouth. It may have been as much as 80mg, but no more than that. Anyway, my vision was nothing but a stained glass overlay of visuals - I have never seen fractals like that with my eyes open before, the euphoria was so intense that I couldn't breathe at times, the body load was surprisingly small - not even a hint of tachycardia or anything. I think I puked but I can't TOTALLY remember... Then ironically, for only the second or third time out of at least 50 uses of this drug, it "told" me that I don't belong in her space, I have overstayed my welcome, and that if I do not let go of the chemical, I will destroy not only my life but the lives of others around me... I haven't had it since.
Best NON-overdose? 2C-E. 26-28mg produced one of the most beautiful trips of my life complete with smelling and seeing a bed of roses in my friend's living room, literally having screaming orgasms from my friend and I tossing energy back and forth... Look up "universal orgasm" in trip reports for a detailed account of that experience.
This one pretty much ties - 60-80mg AMT (yes, I was eyeballing back in 2003) - total ego death and pictures flowed into the room, music came from nowhere, and then I had my first and most profound psychedelic thought process that I've ever had: There is beauty in everything. Nature is beautiful and me being a part of nature, that makes me a beautiful person as well. People that judge based solely on looks get their karma. In my case, I went to the opposite direction and am now what most of the bears consider "fucking hot as hell chaser" - even when I'm lazy about hair cuts and shaving lol.