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What is the mechanism behind amphetamine's cold tollerance?

/navarone/

/navarone/

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Hello people.

I'm posting this because I havent't found nothing concrete on the net about the potentials of amphetamine to increase cold tollerance.
I know amphetamines are normally vasocostricting even though they tend to raise cardiac pressure.
Whenever I'm on amphetamines, even if my body is heaily decongested, I normally have a high tollerance to cold temperatures.
I remember some times where even if I was lightly dressed I was enjoying my hands getting chilled to the point of unsensitivity when taking amphetamines.
I am a person who despite my fast metabolism I suffer cold and heat rather much. Plus I suffer from hypersalivation often. What is the mechanism, behind amphetaminic subtances that clears this phenomnenon including hypersalivation? I would like to know.

Cheers
 
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you're not tolerating cold, you're just producing so much heat that you are able to compensate for the cold weather. Very dangerous btw, you could get hypothermia if you stay out long enough.
As a side note, any part of your body cool enough for you to stop feeling it, is not just dangerous it's plain stupid. Tissue damage begins seconds after being blood deprived (i.e. oxygen deprived), you could loose a finger man.

edit: although it's much easier to loose your dick actually... vasoconstriction, can't live with it, can't roll without it...
 
I think it has to do with the increased metabolic-adrenergic response (i.e. stress) raising blood pressure and enhancing circulation. The vasoconsriction provides a large part too.

Like others have said, it's not healthy to rely on amphetamine to keep yourself warm...
 
Well I think it would depend on the extent it causes vasoconstriction vs it boosts metabolism. If I recall correctly amphetamine was shown to increase thyroid hormones rather quickly after administration.
 
sekio said:
I think it has to do with the increased metabolic-adrenergic response (i.e. stress) raising blood pressure and enhancing circulation. The vasoconsriction provides a large part too.
Click to expand...

I'm thinking that the mechanism is largely perceptual, rather than more directly physiological; remember that d-amphetamine exerts analgesic effects equipotent with morphine as well.

epsilon alpha said:
Well I think it would depend on the extent it causes vasoconstriction vs it boosts metabolism. If I recall correctly amphetamine was shown to increase thyroid hormones rather quickly after administration.
Click to expand...

Amphetamine's effect on basal metabolic rate is relatively modest until we get into the realm of ridiculous dosing schedules (eg, 100 mg of d-amp in an eight hour period). I think that the trade off is mostly vasoconstriction vs. perceptual distortion.

ebola
 
Acute adrenaline increase decreases nociceptive responses. Basically, amphetamine makes you feel less cold not because you are warmer or even are not sensing the cold, but that it's not processed as unpleasant enough to be important.
 
For me it switches up, sometimes on amphetamines il be burning up but most of the time im shivering cold even in warm temperatures.
 
i really don't think this has anything to do with blood pressure or your body producing heat. one can binge on amphetamines for several days, by then they are in the hypoglycemic area and may have a minor case of metabolic acidosis. when you reach that point and havnt ate for 3 days there isnt really anything your body can do to even produce heat from, and you will still not feel cold. the body is more concerned with delivering any sugar available or breaking down any remaining fat to feed the brain as it is number one.

i think the mechanism behind it is the increased sympathetic system, the stress response, and your body basically ignoring and/or shutting down nociceptors/thermoreceptors because it's geared to promote high brain activity for stressful situations. your body doesnt want to waste any energy with the receptors for heat and pain, it saves them for the kinetic receptors so you can run, have good balance, etc.

in a nutshell, body is turning off anything it doesnt NEED (ie the thermoreceptors) and using all available energy for high brain activity, awareness, and skeletal muscle activity instead.
 
I agree with i are spectre. It's simple stimulation of the body - the increased levels of monoamines cause increased noradrenergic and dopaminergic neurutransmission, causing increased activity in cAMP-dependent pathways leading to more heat generated by the energy cycles within the cells.
 
yeah mate, you are actually disagreeing with me. i don't mean to be a jackass or anything. it's my opinion anyway, and i've read info that counters it, too.

what i was getting at though is picture day 5 of a stimulant binge. there really isn't much glucose or even triglycerides that are easily accessible, assuming the user isn't really eating a damn thing, yet the "cold resistance mechanism" is still applying. this ruled out any physical heat generation for me.

i've experienced the phenomena myself and i have to say there wasn't much heat being generated after not eating for several days (this was a major bender, not a common thing). i'm saying that it has to do with the body shutting down unnecessary sensory systems as they are not necessary for survival in the sympathetic mode amphetamines puts you in. in fact you would benefit from the thermoreceptors being shut down because it wont affect judgement as much if you dont feel yourself being extremely cold. i'd be willing to bet it has the same effect on heat, too, but i'm not going to test that.

would anyone care to eat a handful of adderall and crawl in an oven for a while? don't worry, we'll keep it on a real low setting...
 
I would guess vasoconstriction and decreased pain tolerance.
 
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