^Ismene I've noticed in your posts you're inevitably highly opinionated and take a totally polarised stance. You actually mean to tell us that (a) the serotonin model for depression is "total bollocks", and (b) that having made this discovery, which neurochemists are yet to make, was sufficient to prevent any further come-downs. Well fuck me, that makes me and probably most people in the Dark Side feel a bit silly then. Why don't you hop over there and enlighten everyone with your hard-tested knowledge?
Anyway, the most MDMA I ever took was around 700mg by mistake, in one go. The come-up was immense, trails etc. which just faded out to white light. I don't remember anything after that except my mates told me I was writhing around on the floor in the club. They dragged me outside to cool off (it was December) and I had a seizure in the parking lot.
For the following two weeks I suffered from severe anxiety and insomnia, and often experienced something called "Exploding Head Syndrome" (look it up on wiki). After that I had the worst come-down of my life, which triggered a severe depression which lasted about 6 months, which gradually diminished into GAD (general anxiety disorder), which in turn lasted about a year after that.
It has to be said that at the time that this happened I was having a lot of rather nasty issues at home and school (I was 17) - I'm by no means saying that .7g of MDMA gave me a year-long come-down, but it definitely tipped me waaaay over the edge.
It's one of the worst drugs to abuse in terms of the emotional instability it can cause.
That being said, my best mate regularly drops between 10 and 30 pills a night when he goes out raving (which he does very often) and he's a highly emotionally stable person (albeit having severe issues with drug abuse lol). Everybody is different I suppose.
The questions around serotonin and its relationship with mood could be debated on here for days and we would be no further forward. However there is no doubt that a significant number of studies have shown SSRIs not to be effective in the treatment of depression, that much we can be sure of. I took MDXX pretty much every week for about 8 years and then a bit more sporadically for another couple or so. Having taken it for such along period it wouldn't be unusual for me to be taking more than half a gram over a night out for a number of years.
I now suffer from depression and have tried 4 different SSRIs and they just made me ill, in some cases very ill, I'm a single case but for me that throws the case for MDXX damaging or lowering your serotonin levels and / or the case for SSRIs for the treatment of depression. As I say that's just the one case but the evidence on both sides is out there for all to read and opinionate on.
As for people doing 10-20 "pills", even back in the day I knew people that did that kind of number and usually ended up a gurning sweaty mess in the corner, but what's a "pill" if its only got 10mgs of MDXX in it then 30 would be fine. (it's all down to purity in the end
The only real comedown I suffered from MDXX was nasty nausea for days afterwards which got worse over the years, but I have a weird immune system and I think I may have started to become intolerant to the substance through exposure, as for suicide Tuesdays I'm not really convinced the effect was any worse than what I'd get from doing a whole shit load of speed, standard stim comedown IMO.
