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What exactly is going on when you eat shrooms?
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nearjat
Bluelighter
Whoever told him that is retarded. Or just misinformed 
Mushrooms contain a compound called psilocybin, it's a psychedelic drug of the tryptamine family. One way I've heard it's mechanism of action described is that it does what serotonin does, by locking into certain receptors, but causes an entirely different reaction because obviously it's not serotonin. What results is a distortion in types of perception that serotonin normally handles. Certain parts of your brain start talking to other parts in your brain that normally wouldn't communicate. I'm fever delirious and kinda high so sorry if that didn't make any sense.
Mushrooms contain a compound called psilocybin, it's a psychedelic drug of the tryptamine family. One way I've heard it's mechanism of action described is that it does what serotonin does, by locking into certain receptors, but causes an entirely different reaction because obviously it's not serotonin. What results is a distortion in types of perception that serotonin normally handles. Certain parts of your brain start talking to other parts in your brain that normally wouldn't communicate. I'm fever delirious and kinda high so sorry if that didn't make any sense.
I'm not an expert on neurochemistry, but basically, as I understand it, magic mushrooms work like this: psilocin (an active chemical in magic mushrooms) enters the brain and acts on receptor cells in the brain that would normally respond to the naturally occurring brain chemical serotonin. The reason that they respond to psilocin is that psilocin is chemically quite similar to serotonin. Presumably the various effects on sensory perception (for example) are due to receptors in sensory areas of the brain reacting to the psilocin (because it's like serotonin) but reacting weirdly (because it's not exactly like serotonin). Likewise, other effects are due to similar action on serotonin receptors in other areas of the brain (areas more involved in cognition than sensory perception, etc).
DwayneHoover
Bluelighter
hahaha! GRRRRRRRRR! Man I hate these lying bags of shit at AA and other anti-drug Nazi scum. What a bunch of total 100% lies.
Dude, do some googling and research on your own, and you find plenty to read about.
Jesus H. Christ... the younger generation sure are lazy.
Dude, do some googling and research on your own, and you find plenty to read about.
Jesus H. Christ... the younger generation sure are lazy.
melange
Bluelighter
my brain is bleeding guys
any major dude
Bluelight Crew
its crazy how much misinfo like this there is out there. I had a friend tell me the same thing about LSD one time several years ago. I calmly & rationally explained the pharmacology of 5ht2a psychedelics, and his response was "No, some dude told me it makes your brain bleed" 8)
And as for mushrooms, they contain both psilocin & psilocybin. Psilocybin is metabolized into psilocin in your body, and psilocin is what binds to a number of different receptors in your brain. Mostly serotonergic, but a smattering of other ones as well. The serotonin receptor subtype that currently appears to be the most necessary for "psychedelic" type activity is called 5-HT2a, DMT, LSD, Psilocin/Psilocybin, 2c-e, mescaline, etc are all agonists of this receptor. There is a significant amount of activity at other receptors, including some dopaminergic & adrenergic which are likely responsible for the stimulation, decreased appetite, etc.
And as for mushrooms, they contain both psilocin & psilocybin. Psilocybin is metabolized into psilocin in your body, and psilocin is what binds to a number of different receptors in your brain. Mostly serotonergic, but a smattering of other ones as well. The serotonin receptor subtype that currently appears to be the most necessary for "psychedelic" type activity is called 5-HT2a, DMT, LSD, Psilocin/Psilocybin, 2c-e, mescaline, etc are all agonists of this receptor. There is a significant amount of activity at other receptors, including some dopaminergic & adrenergic which are likely responsible for the stimulation, decreased appetite, etc.
stirfry
Bluelighter
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Psilocin, like other 'typical' psychedelics such as LSD, mescaline etc, seem to work by activating certain serotonin (aka 5-HT) receptors. Specifically, activation of the serotonin 5-HT2a sub-receptor is common to all drugs that produce these effects (more technically referred to 5-HT2a agonists). While not all 5-HT2a agonists are psychedelic, it seems that all psychedelics are 5-HT2a agonists. Psychedelic drugs also have activity at other parts of the brain. The varying actions that accompany the 5-HT2a agonism is why LSD, mescaline, psilocin etc. have slightly different feelings.
The brain bleeding thing is complete B.S.. If your brain actually was bleeding, you would die.
The brain bleeding thing is complete B.S.. If your brain actually was bleeding, you would die.
pins&needles
Greenlighter
my friend told me once that when you take shrooms, since they are a fungi, they give your body an infection of some sort and what makes you trip is your body trying to fight off the imfection. Has anyone else heard this b4? Or is my friend just an idiot?
stirfry
Bluelighter
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A common theory I've heard on the action of mushrooms from uninformed users is that the psilocybin is a poison, and it's the bodies reaction to being poisoned that causes the trip.
rincewindrocks
Bluelighter
please tell me this post was a troll....considering all the reasoned and informed responses just inches above this, then this guy was either LOLing, or smoking too much
pins&needles
Greenlighter
Damn dude chill the fuck out Was just wondering if anyone else has heard that theory before.
rincewindrocks
Bluelighter
oh im chill....but my point was, this was a completely useless post on your part, thereby causing me to wonder if it was trolling. as i said, there are several posts right above yours that completely describe the action of shrooms and several other psychedelics, then you come in with another ridiculous theory. made me wonder
pins&needles
Greenlighter
Dude I never said it was MY theory. I heard it from a friend and was WONDERING if anyone else has heard that b4. I didnt know if he made it up or what.Is that unacceptable? Wasnt "trolling"
DwayneHoover
Bluelighter
Yes, you hit the nail on the head.... your friend is a TOTAL idiot! 8) You come in a close second for not being able to be bothered to lift two index fingers and google to find any one of like 500 sites and FAQs with encyclopedias full of detailed scientific info about shrooms.
Isnt there any way to have a robot filter out such things and redirect them to dumblazydrugquestions.com?
Then again I guess if that were the case, we wouldn't get to have the glee of ripping them to shreds like a pack of starving hyenas. Sorry mate! Nothing personal, really. But the only way to reduce the incidence of silly pointless questions like this here is to savagely ridicule them. Doesn't seem to be helping much. Hmmmm.....
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pins&needles
Greenlighter
LOL thats what I thought thanks
digital_phreedom
Bluelighter
Try checking out the "myths" section on the LSD page in erowid.. There is some crazy stuff there.
Things I've heard from other people about mushrooms/LSD:
Take more than 7 times and you're legally insane.
They make your brain bleed.
They make your brain bleed, which then drips onto your spinal cord, and that's what fucks you up.
They can only be tested for in a spinal tap.
You can make LSD out of banana peels (or fosters beer).
LSD has a half-life, which means it never leaves your body. It stays in there forever because it keeps splitting in two, but never goes away all the way. (rofl)
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I don't know how all the myths got started.. but there is certainly some pretty ridiculous stuff out there. But what really gets me is how STRONGLY these people believe them! Even when I explain the pharmacology behind it, or SHOW them a link on erowid.. They still usually reply with "No dude, my friend has eaten a lot of acid. He knows what he's talking about."
Ok then, believe whatever you want..
And to the OP:
Yes, people at AA are mostly (in my experience) not very knowledgable about the science behind drugs. This goes for NA/CA as well.
And while you could have easily checked on erowid or used a search engine to get these answers, big props to you for being smart enough to ASK and not immediately believe such ridiculous things!
Things I've heard from other people about mushrooms/LSD:
Take more than 7 times and you're legally insane.
They make your brain bleed.
They make your brain bleed, which then drips onto your spinal cord, and that's what fucks you up.
They can only be tested for in a spinal tap.
You can make LSD out of banana peels (or fosters beer).
LSD has a half-life, which means it never leaves your body. It stays in there forever because it keeps splitting in two, but never goes away all the way. (rofl)
-------------
I don't know how all the myths got started.. but there is certainly some pretty ridiculous stuff out there. But what really gets me is how STRONGLY these people believe them! Even when I explain the pharmacology behind it, or SHOW them a link on erowid.. They still usually reply with "No dude, my friend has eaten a lot of acid. He knows what he's talking about."
Ok then, believe whatever you want..
And to the OP:
Yes, people at AA are mostly (in my experience) not very knowledgable about the science behind drugs. This goes for NA/CA as well.
And while you could have easily checked on erowid or used a search engine to get these answers, big props to you for being smart enough to ASK and not immediately believe such ridiculous things!
I knew I'd get at least one person telling me to google this shit. I prefer getting answers from people on forums. I just like seeing all the different facts/opinions and people correcting each other, etc.
He said they told him the same thing about LSD. Don't worry, though, I didn't buy it and neither did he.
Thanks ladies and gentlemen. I don't really understand all this lingo but as long as my brain isn't bleeding I'm cool!
On a side note, how do you pronounce these:
psilocin
psilocybin
digital_phreedom
Bluelighter
Psilocybin = Sill - uh - Sigh - Bin .. (that's my half assed attempt at spelling it phonetically)
And I think Psilocin is pronounced: Sigh - Lo - Sin , but I may be wrong about that one.
And I think Psilocin is pronounced: Sigh - Lo - Sin , but I may be wrong about that one.
DwayneHoover
Bluelighter
Thanks for not freaking out at my GRRRRRRRR! And I love how you say you asked because you like seeing all the people correcting each other. Sounds suspiciously like a troll to me, but I think MODS should allow this just once, since you seem to have a very reasonable set of expectations, and, to be honest I rather enjoy a good fracas myself, haha!
Frankly, I'm a little disappointed no one reacted to my description of BL PD as "a pack of starving wild hyenas."
Frankly, I'm a little disappointed no one reacted to my description of BL PD as "a pack of starving wild hyenas."
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Yeah dude, i think after your brain bleeds it allows spores to grow in there which makes more psilocin and causes mental disorders and flashbacks and u keep on trippen till fuzzy white stuff growz out yer ears.
Heh. Rumors are funny but so annoying. When I was 15 , a year into doing acid, the common rumor was 'it makes your brain bleed into your spine' and 'it stays in your spine to cause flashbacks'. I am glad even at this gullible age I knew it was BS, although I didn't know it was 5HT2-A partial agonism, but I'm not sure anyone did back then.
Best explanation without neurochemistry is, it turns off some sensory inhibitory circuits in the brain, leading to more sensory information processing (and overloading). Or to reduce it further, "it turns on parts of your brain that aren't normally on".
Heh. Rumors are funny but so annoying. When I was 15 , a year into doing acid, the common rumor was 'it makes your brain bleed into your spine' and 'it stays in your spine to cause flashbacks'. I am glad even at this gullible age I knew it was BS, although I didn't know it was 5HT2-A partial agonism, but I'm not sure anyone did back then.
Best explanation without neurochemistry is, it turns off some sensory inhibitory circuits in the brain, leading to more sensory information processing (and overloading). Or to reduce it further, "it turns on parts of your brain that aren't normally on".