What effect will my Meth tolerance have on my Molly high?

[livethroughthis]

What effect will my Meth tolerance have on my Molly high?

hey guys, i hope someone can help me out.
sorry if this has already been answered but i haven't found it in making my way through the multitude of other posts under which it would be buried anyway.
i've been smoking meth for the past couple days. not super heavily, but a mild bit of a bender. late nights and just a couple hours of sleep. so you know when you do that and your tolerance builds super fast and you can't get the rush until you stop for a little while and then try it again etc....
well that's kind of where i'm at with the meth. so instead of getting more i decided to try molly thinking maybe i could get a fun high from a different substance, switching it up and it was either molly, blow or more meth. so i went with the molly.
i haven't done molly specifically before, but i have done mephadrone on a variety of different occasions and once a straight mdma pill. these instances were all a few years ago. it's my understanding that the effects of each form are all different depending on a variety of variables but that for the most part they have a similiar type of high.

in any event....

my question is not so much about the combination of the molly and the meth but more regarding whether or not the molly high would be lost the way that meth one is sort of lost at this point due to being just the littles bit strung out.

how much will my meth tolerance affect my molly high?

i smoke my meth and i would be planning to blow the molly.
any input would be greatly appreciated.
thanks guys.

 

[hatrix]

It should have a significant cross tolerance. While methamphetamine doesn't playing a strong role on SERT (minimal serotonin activity), it does however releases a lot of dopamine.

MDMA releases both serotonin and dopamine. Dopamine is more responsible for the euphoria associated with MDMA, while serotonin is more of the tactile feelings and such. It's a more potent serotonin releaser than dopamine, but none the less it still releases a lot of both. That's why it's such a popular and great drug.

Cross tolerance should be very apparent as far as the dopaminergic feelings go. You roll will most likely be dampened in effects.

Best take a break before you decide to take any MDMA.

Combining them however, while said to be safe (as in no deadly interactions), I read a report describing it as a weird and strange high, where the person felt sort of tweaky:

ive only ever tweaked and rolled in conjunction (that the corect word) and it kinda workd. mind you that was only after tweaking for a day, my roll was really smacky and confusing, in fact i dumped the strongest tabs in my life.

 

[pasha]

^Yes.

In studies done in rats, methamphetamine and MDMA appeared to share some cross-tolerance.

 

[Venrak]

I don't have any studies to back my suspicions, but judging by MA's 5HT releasing properties in comparison to those of DA release, there should be some cross tolerance between it and MDMA, but I would think it to be very incomplete.


...unless there's some issue about a shared transporter protein between DA and 5HT. I don't know, maybe Chrom will be able to tell us

 

[pasha]

^ Serotonin does serve a transporter for dopamine. Nonetheless I would be more inclined to agree with you that the cross-tolerance is incomplete. Methamphetamine is more potent at dopamine, while MDxx is more potent at serotonin, which ultimately means that methamphetamine would significantly raise tolerance to MDxx dopaminergic properties, and MDxx would significantly raise tolerance to methamphetamine's serotonergic properties.

One could however hypothesize that methamphetamine would do more damage to MDxx, since both drugs are essentially amphetamines and rely on their dopaminergic/noradrenergic properties above all, and methamphetamine is the more potent adrenergic/dopaminergic of the two.