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What drugs effect MDMA tolerance?

J

jess046

Bluelighter
Joined
Nov 14, 2012
Messages
217
Obviously anything that uses serotonin will affect mdma tolerance, however, I was wondering to what degree. As in, do all serotonin related drugs need to be avoided during the month breaks between mdma usage to insure no tolerance builds up and all nasty side effects are avoided? I was thinking of drugs such as:

MDA
METH
AMT
2CB
MEPHEDRONE
BK-MDMA

These are the ones I thought off the top of my head as also being common drugs and serotonin based drugs. Do you need to space out usage monthly to avoid tolerance like MDMA or are these drugs safe to use in the 'in-between' time between doses of MDMA?
 
The fewer amphetamine-like stimulants you use the better, but the big ones to avoid are MDA, Methylone, and the APB's.
 
Funny, I was coming to ask the same question, though I was going to add coke and moxy to the list. Any thoughts on those?

How about from an HR perspective? Are any particularly more dangerous besides "losing the magic"?
 
I only know MDMA and never used any drugs(only coke& ket once).
Coke & ket are not serotonin releasers I think? Can someone enlighten me?
 
Ketamine works by NMDA-Antagonism. Cocaine is a serotonin–norepinephrine–dopamine reuptake inhibitor which means it doesn't release serotonin but it prevents it being reuptaken.

Also, not only serotinergic drugs have crosstolerance with MDMA. MDMA also releases norephinedrine and dopamine and almost all stimulants effect these in some ways. For example if you have a high tolerance for amphetamines and you take MDMA, it could cause that your roll is less energetic and euphoric, perhaps even "lacking something".
 
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