From what I've found, most people who experience extreme sides fit into two categories. They run high doses of Tren (500mg+) or they run Tren in conjunction with high doses of test. Obviously if you run a long ester and run into sides, you're going to be in a world of hurt. The best two ways I've found to approach Tren the first time is to either start at a low dose of Tren E @ 200mg week and work your way up, or to start on a dose of 40-50mg ED of Tren Ace. I understand Tren is a heavy hitter, and have an idea of what to expect with the sides if they present themselves. Ideally, I have no urge to go above a 300mg Test/300mg Tren level.