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  • BDD Moderators: Keif’ Richards

What do you think of nicotinoyl-GABA?

S

swimming.since.99

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May 31, 2015
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Nicotinoyl-GABA, better know as "Picamilon", is a synthetic GABA analogue. We all know that GABA can't punch through the blood-brain-barrier, however, the nicotinoyl group allows it to easily pass through the blood brain barrier, where it is hydrolysed into GABA and Niacin, GABA instantly acts as a direct GABA-A agonist, while niacin acts as a vasodilator.

I want to hear your opinion on this substance.

My experience:
Picamilon tabs at 100mg each, these are x5 larger than the standart 20mg dose, I took only 1 when I was going through WD from Flubromazolam at 8mg (equivalent to 24mg Clonazepam, *sigh*), the only reason I survived those WDs is because of Picamilon and of course because of Phenobarbital and valerian constituents + ethanol in my little Korvalol mix.

I took it on an empty stomach and effects were felt 5mins later, and dayum... I would compare this to Amobarbital, short acting, effects only lasted for an hour, but very strong.
WD stopped immediately, and my head felt like a stuffed pillow, along with a careless and floaty feeling. Also a slightly drunk feeling.

I threw in valerian constituents + pheno + alcohol, since their PAMs and they will hold that GABA in place. And it worked, WDs were gone for about 9 hours. Picamilon also sped up the WDs.

I got a script for diazepam for panick attacks during travelling, but I only got x8 10mg tabs so I used Picamilon+Pheno+Valerian+Ethanol in order to potentiate Valium to the max, and it worked again :)
 
I had a GNC guy who really knew his information, recommend Picamilon. The fact that this stops withdrawals from Flubromazolam, intrigues me very much. swimming.since.99, I know what I think, but do you feel this would be a great taper medicine on its own? I'm basing this off the safety profile of the racetams in general. I am currently on 1mg/3x day of clonazepam. I am prescribed this amount and it works great for me, I would simply like to lower my dose a bit just to give my receptors a break.

According to your math Flubromazolam is 3x stronger then clonazepam. I'm on a very low dosage by comparison to you.

What are the negatives to using Picamilon only to taper?
Thanks for any reply.
 
Speed King said:
I had a GNC guy who really knew his information, recommend Picamilon. The fact that this stops withdrawals from Flubromazolam, intrigues me very much. swimming.since.99, I know what I think, but do you feel this would be a great taper medicine on its own? I'm basing this off the safety profile of the racetams in general. I am currently on 1mg/3x day of clonazepam. I am prescribed this amount and it works great for me, I would simply like to lower my dose a bit just to give my receptors a break.

According to your math Flubromazolam is 3x stronger then clonazepam. I'm on a very low dosage by comparison to you.

What are the negatives to using Picamilon only to taper?
Thanks for any reply.
Click to expand...
There is a huge difference between benzo tolerance and actual GABA-A tolerance. Benzo tolerance is when the alpha sub-units of the receptor are damaged/changed by the molecule of a benzo e.g Clonazepam molecule, this type of tolerance does not cause withdrawals/dependace etc. GABA-A tolerance is when a direct agonist like Picamilon causes up-regulation of the receptors and causes GABA to seize it's release, leading to terrifying WDs. Constantly consuming benzos will also cause GABA-A up regulation and seizing of GABA release but on a much smaller scale.

By switching to Picamilon you're stepping up the habit to the next level, and Picamilon is also very short lived, since it's effects only last for an hour. If you want to taper with Clonazepam and occasionally stop WDs with Picamilon, then that's absolutely fine, and it will work great, but then again, the reason why my WDs where relived for 9 hours is because Phenobarbital held Picamilon on that receptor for extra 8 hours. I strongly recommend that you switch to a smooth, low-potency long acting benzo like Flurazepam and lower the dose by 5mg of Flurazepam every 2 weeks, if possible, but of course you can taper with Clonazepam, about 0.25mg every 2 weeks, but it will be more painful because of Clonz's potency. Avoid barbiturates and RC benzos at all costs, I hope this helped, stay safe.
 
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