They will cause undesirable anti-cholinergic effects.. Same as higher doses would, though not quite as severe.. Dry mouth, RLS, hallucinations, sedation. Look it up on wikipedia, it will iist all side effects of higher doses. It is not pleasant at all, and I recommend not trying it. Doses over 100mg are absolutely not necessary and will just cause unwanted side effects. Stick to 50-75mg for sleep if need be.
I've experimented several times with diphenhydramine. Being a small guy (about 120lbs at the time), I don't think I've ever gone above 350mg (I think). After becoming aquatinted with the effects, I found that 200mg puts me in a semi-sedated, "stoned," drunken state. It really is an odd high. Its unbalancing and intoxicating in a way that reminds me a bit of alcohol, but without any of the "WOO! PARTY!" effects. If anything it gives a bit of a dead feeling, with body load and some mind-numbing. I've also experienced those anticholinergic side-effects like dry mouth, loss of coordination, impaired (blurry?) vision, and probably a couple others, but those stand out. However my experiences differ a bit from what wikipedia says to expect from anticholinergics. It says that they may cause increased heart rate and increased body temperature. To me its felt like my heart had to work a little harder to pump, but wasn't really going faster. I've also experienced a feeling of cold, especially in my hands and feet, and under my fingernails turned a bit purpley-blue which seemed to indicate decreased blood-flow to the extremities. And at higher doses its just weird. A sedating mind fuck without many positive effects, in my opinion.
So its kind of a "meh" drug for me. Not great, and the side effects make the primary effects not really worth it. I don't really recommend it, but I admit that there have been times when I felt like retreating from the world for a bit and found that a bottle of those little pink pills is all I have on hand. Plus sleep comes easily.
One last thing, I'd avoid mixing it with marijuana. I had a really bad experience from it that I'll put below, in NSFW tags (Its longer than I thought it would be).
NSFW:
There was one time quite a while back that I took 200mg of DPH in the form of crushed tablets (quicker onset), and when I started to come up I smoked some potent herb. Now, I had no tolerance to either substance and not that experienced with any drugs at the time. I ended up having CRAZY visual and auditory hallucinations, all the while being in a stupid, delirious, stoned state. My senses were just badly warped. I even hallucinated a conversation with my mom. Also a very colorful monkey banging cymbals together, like those wind-up toys. But when I realized that I was experiencing/seeing these, they'd suddenly disappear and something else would happen. It was REALLY fucking bizarre, but in retrospect quite interesting. The problem is that for about a week or more after I experienced little distortions in the world around me. Like something black moving away in the corner of my eye, a flying fly that turned out to not be real, etc. This all came to a head at a party about 4 days after. It was a halloween party that a friend's family was throwing, and I was there hanging with my friend and people, smoking some bowls, etc (I hadn't smoked since that trip). Then the weird shit started happening. There were two metal bands playing that night, and the members and their friends started showing up. This was all older people, mostly dudes, and then this one guy. He wandered in behind everyone else, and was just standing there with an open mouthed, kinda crazy looking grin. Not saying anything. I started getting really anxious, thinking that it was some fucker on PCP or something who had wandered in and was going to pull a knife out and fuck shit up. Turned out it was a dude who had brain damage from a stroke who was there with a band, but still. They ended up dressing him up like a zombie and he walked around doing weird freaky shit. It was not cool. Plus I was getting baaaad vibes from some dudes who were pissed off about the PA system or some shit. I ended up having to find my friend and walk around the block then go chill in her room. After I calmed down and came down a bit I was cool and was able to have a few drinks, enjoy the music, and have a good time, but it was a baaad start to the evening. Its the one and only time I've almost had a panic attack on weed. Never doing that combo again, even though part of my wants to revisit and explore that crazy headspace I was in.