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What can repair or balance brain chemistry

You guys have given me some superb advice, I now have to stock up on those suggestions and it seems a long list of experiments await me. Thanks everyone.
 
Sometimes I've had issues with thermoregulation after using the 2c-x family for days and weeks afterwards. I've always wondered by what mechanism these substances can cause this problem. The problem usually goes away after a period of nonusage. Its interesting you mentioned damage to the hypothalamus, something I will look into...
 
I appreciate and support the comments regarding exercise and nonuse of drugs, however i would strongly recommend the use of Antioxidents such as green tea caffine free extracts, enxogenol, alpha lipolic acid. Use careful esculating dosage structures for safety.

You didnt have the toxicity studies conducted at the time of injury?(gas chromotography) E's are infrequently pure MDMA.

Is it possiable you had a persausive Development disorder prior to injury?

This is my instinct how i would treat this, but im no doctor nor do i understand the actual damage.



Sigma-2 agonist such as tramadol, memantine,modafinil, ibogaine or Ifenprodil
cause pro metabolic/neurogenic effect in vivo. Sigma-2 agonist exhibt NMDA antagonist(complex), 5-htp 3a antagonist, D2 agonist and cholinagenic antagonist properties.antagonists of 5-htp 3a decrease the inhibtion of the hypothalmus and increase Long Term Depression(learn about opposite of long term potentiation) a common mechanism of action of drugs of "abuse".

amphetamines have a strong sigma-2 agonist component to the mechanism of action.

I useful article
Extrasynaptic NMDARs oppose
synaptic NMDARs by triggering CREB
shut-off and cell death pathways

Here we report that synaptic and extrasynaptic NMDA (N-methyl-D-aspartate) receptors have
opposite effects on CREB (cAMP response element binding protein) function, gene regulation and
neuron survival. Calcium entry through synaptic NMDA receptors induced CREB activity and brainderived
neurotrophic factor (BDNF) gene expression as strongly as did stimulation of L-type calcium
channels. In contrast, calcium entry through extrasynaptic NMDA receptors, triggered by bath glutamate
exposure or hypoxic/ischemic conditions, activated a general and dominant CREB shut-off pathway
that blocked induction of BDNF expression. Synaptic NMDA receptors have anti-apoptotic
activity, whereas stimulation of extrasynaptic NMDA receptors caused loss of mitochondrial
membrane potential (an early marker for glutamate-induced neuronal damage) and cell death.
Specific blockade of extrasynaptic NMDA receptors may effectively prevent neuron loss following
stroke and other neuropathological conditions associated with glutamate toxici

You maybe able to find a neurologist who could prescribe you traxaprodil or ifenprodil, these are potent antidepressents which work by block extrasynatpic NR2B subunits of the NMDA receptor. They also have significant agonist effects on sigma-2 adaptins throughout the cells of the brain.

I trust and believe very little in our world, i try to see the effects of utility maximisation. Science is often design to misrepresent or blantently contradict fact.

PS Lithium could be effective
 
No pure glutamine, you suffer from excitoxicity
Piracetam maybe toxic to most people,
Magnessium and managanese are definitly worth trying

Search ifenprodil hypertension, ifenprodil decrease the hypothalamic hypertensive response.
 
Krill oil (best fish oil). Vitamin D3. B vitamins. Echoing the previous poster, piracetam is close enough to the excitotoxin glutamate that I would not take it myself. But then, I also avoid MSG.

Be careful about manganese, as it can be toxic in high amounts. Magnesium is very good. Chromium picolinate can help. GABA supplements helped mediate my moods a bit. (Like a really washed-out version of klonopin in a way).
 
tramadol is a non-neurotoxic SRA as well. maybe it can provide some help. Im sure your doctors are willing to Rx you basically anything to fix this issue or at least help alleviate the symptoms. Get

another thing you could try is CB1 agonist if its possible in your condition. its been linked with neurogenesis
 
Advaneuro said:
No pure glutamine, you suffer from excitoxicity
Piracetam maybe toxic to most people,
Magnessium and managanese are definitly worth trying

Search ifenprodil hypertension, ifenprodil decrease the hypothalamic hypertensive response.
Click to expand...

can you provide a source for piracetam toxicity?
 
again i have to ask for a source for piracetams strong 5ht2a activity

they use it here for some medical conditions. up to 30 grams per day for years
 
i woudnt suggest it super longterm. you get the needed choline from daily food intake.

dietary supplementation with choline has been linked with increased risk of colon and rectum cancer
(source:
http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.nu.01.070181.000523
http://www.ncbi.nlm.nih.gov/pubmed/10654290
)

then again you probably didnt plan on eating this stuff for years and years. Here they use choline supplementation after traumatic brain injury so i guess it can do some good :)


can i ask what kind of reaction did you have to ephedrine + caffeine ?
 
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I'd like to see some trustworthy sources for the supposed piracetam toxicity too. I know there are plenty of info on it being used for more than 30 years and without any toxicity concern. It would be very strange if it was really toxic and no one noticed it.
Also even IF there was the basis for toxic issues with piracetam, I'd like to see some percantages as well; everything can be toxic for one person in a million, even plain water.
 
i cannot find any publications of piracetam toxicity and i searched for a while. It seems to be well tolerated drug. Cannot find any evidence of 5ht2a agonism either

like i said they are pumping 30 grams of this stuff into some patients. If it would be toxic there would be publications by now
 
so it seems :) so to the OP dont dismiss piracetam over his statements
 
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