In 2001 a recreational drug overdose to amphetamines, mda and ecstasy pill resulted in severe hyperthermia, neurotoxicity and hospitalization and damaged my autonomic system leaving me disabled with a neurological condition. After many years of extensive tests it has now been confirmed all my abnormal symptoms are directly a result of generalized damage to the hypothalamus, the Serotonin (5HT) terminals in the brain and other neurotransmitters and the unusual symptoms I'm having are due to loss of functional neurons.
At first there was many theories that my liver enzymes, thyroid, metabolism or even a psychosomatic disorder was responsible for my unusual symptoms consisting of abnormal thermoregulation and constant fevers for 9 years, adverse reactions towards all opiates, stimulants, sedatives, SSRI's and analgesics which result in hyperthermia, spasms and distrupted vitals other odd ill reactions that occur towards even the changes in my own body chemicals that are released during arousal and sexual activity, excitement and anger, during digestion or hunger, or waking up or going to sleep.
Based on the suspicions I have had various tests including cytochrome p450 test, catecholamines test, thyroid function, liver function, sweat and thermoregulation test, pschological evaluations. Except for the sweat and temperature test everything else came back normal, so my specialists have now concluded through a methdos of exclusion that all my symptoms are directly a result of a damaged to the brain. Although I was already diagnosed with autonomic dysfunction there was still an element of doubt as to where exactly in the body my adverse reactions were originating from as there are various areas that process and metabolize drugs.
I have been told even though there is no cure that I could still try various medications that interact with hypothalamic neurotransmitters to see if they help, Ive been told Cabergoline increases dopamine, Fluoxetine increases 5HT, while Venlafaxine increases both noradrenaline and 5HT, but I have been reluctant to start on these medications because it is somewhat an experiment and although it is certain I lack balance in my body, it is still uncertain whether it is due to either overcompensation or under-activity as result of lost neurons and whether I need inducers or inhibitors to restore the balance.
So if my symptoms are due to over excessive noradrenaline and I take an inducer drug that increases noradrenaline I could turn out worse, so I have to tread with caution, although I am working together with my specialists I still have faith in you guys with all the knowledge about the brain chemistry that you guys are capable of also helping me, so I would like information on safer alternatives to the drugs recommended but no SSRI's as they worsen my fever and sleep, I also need suggestions on drugs that inhibit the 5ht, dopamine and noradrenaline just in case my symptoms lay at the opposite end of the spectrum. Thanks.
At first there was many theories that my liver enzymes, thyroid, metabolism or even a psychosomatic disorder was responsible for my unusual symptoms consisting of abnormal thermoregulation and constant fevers for 9 years, adverse reactions towards all opiates, stimulants, sedatives, SSRI's and analgesics which result in hyperthermia, spasms and distrupted vitals other odd ill reactions that occur towards even the changes in my own body chemicals that are released during arousal and sexual activity, excitement and anger, during digestion or hunger, or waking up or going to sleep.
Based on the suspicions I have had various tests including cytochrome p450 test, catecholamines test, thyroid function, liver function, sweat and thermoregulation test, pschological evaluations. Except for the sweat and temperature test everything else came back normal, so my specialists have now concluded through a methdos of exclusion that all my symptoms are directly a result of a damaged to the brain. Although I was already diagnosed with autonomic dysfunction there was still an element of doubt as to where exactly in the body my adverse reactions were originating from as there are various areas that process and metabolize drugs.
I have been told even though there is no cure that I could still try various medications that interact with hypothalamic neurotransmitters to see if they help, Ive been told Cabergoline increases dopamine, Fluoxetine increases 5HT, while Venlafaxine increases both noradrenaline and 5HT, but I have been reluctant to start on these medications because it is somewhat an experiment and although it is certain I lack balance in my body, it is still uncertain whether it is due to either overcompensation or under-activity as result of lost neurons and whether I need inducers or inhibitors to restore the balance.
So if my symptoms are due to over excessive noradrenaline and I take an inducer drug that increases noradrenaline I could turn out worse, so I have to tread with caution, although I am working together with my specialists I still have faith in you guys with all the knowledge about the brain chemistry that you guys are capable of also helping me, so I would like information on safer alternatives to the drugs recommended but no SSRI's as they worsen my fever and sleep, I also need suggestions on drugs that inhibit the 5ht, dopamine and noradrenaline just in case my symptoms lay at the opposite end of the spectrum. Thanks.

