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What can repair or balance brain chemistry

Unlucky

Bluelighter
Joined
Apr 26, 2007
Messages
594
In 2001 a recreational drug overdose to amphetamines, mda and ecstasy pill resulted in severe hyperthermia, neurotoxicity and hospitalization and damaged my autonomic system leaving me disabled with a neurological condition. After many years of extensive tests it has now been confirmed all my abnormal symptoms are directly a result of generalized damage to the hypothalamus, the Serotonin (5HT) terminals in the brain and other neurotransmitters and the unusual symptoms I'm having are due to loss of functional neurons.

At first there was many theories that my liver enzymes, thyroid, metabolism or even a psychosomatic disorder was responsible for my unusual symptoms consisting of abnormal thermoregulation and constant fevers for 9 years, adverse reactions towards all opiates, stimulants, sedatives, SSRI's and analgesics which result in hyperthermia, spasms and distrupted vitals other odd ill reactions that occur towards even the changes in my own body chemicals that are released during arousal and sexual activity, excitement and anger, during digestion or hunger, or waking up or going to sleep.

Based on the suspicions I have had various tests including cytochrome p450 test, catecholamines test, thyroid function, liver function, sweat and thermoregulation test, pschological evaluations. Except for the sweat and temperature test everything else came back normal, so my specialists have now concluded through a methdos of exclusion that all my symptoms are directly a result of a damaged to the brain. Although I was already diagnosed with autonomic dysfunction there was still an element of doubt as to where exactly in the body my adverse reactions were originating from as there are various areas that process and metabolize drugs.

I have been told even though there is no cure that I could still try various medications that interact with hypothalamic neurotransmitters to see if they help, Ive been told Cabergoline increases dopamine, Fluoxetine increases 5HT, while Venlafaxine increases both noradrenaline and 5HT, but I have been reluctant to start on these medications because it is somewhat an experiment and although it is certain I lack balance in my body, it is still uncertain whether it is due to either overcompensation or under-activity as result of lost neurons and whether I need inducers or inhibitors to restore the balance.

So if my symptoms are due to over excessive noradrenaline and I take an inducer drug that increases noradrenaline I could turn out worse, so I have to tread with caution, although I am working together with my specialists I still have faith in you guys with all the knowledge about the brain chemistry that you guys are capable of also helping me, so I would like information on safer alternatives to the drugs recommended but no SSRI's as they worsen my fever and sleep, I also need suggestions on drugs that inhibit the 5ht, dopamine and noradrenaline just in case my symptoms lay at the opposite end of the spectrum. Thanks.
 
The best cure in my experience to an out of whack brain is regular exercise (especially cardio workouts), eating well, lots of protein, fruits, vegetables, a daily multi-vitamin supplement, a regular sleep pattern of at least 8 hours a night and most importantly NO DRUGS.

Hope this helps if you're not already doing these things, they're the obvious go to cures. Lead a healthy lifestyle.
 
You could try LSD, it has agonistic and antagonistic actions all over the serotonergic system, as well as the dopaminergic and noradrenergic systems.

Also, cabergoline (also an ergoloid) doesn't increase dopamine the same way that fluoxetine increases 5-HT.

Something else atypical? How about salvinorin A? I've never tried it myself, but who knows. And how about nitrous oxide?

Maybe, LSD + N2O + Salvia = Success!.....
 
The best cure in my experience to an out of whack brain is regular exercise (especially cardio workouts), eating well, lots of protein, fruits, vegetables, a daily multi-vitamin supplement, a regular sleep pattern of at least 8 hours a night and most importantly NO DRUGS.

Hope this helps if you're not already doing these things, they're the obvious go to cures. Lead a healthy lifestyle.

seconded

lots of excercise like a shitload

and to the guy who said lsd stop bein an ass
 
You guys are definetly pro because your suggestions in regards to excercise was a miracle cure in the past for some of my symptoms.

Even though I have lost my ability to sweat due to my damaged Autonomic System after excercising religiously every day for 5 months I found that at the end of that 5 months I began to sweat a little bit and some of my fevers reduced, it was very exciting, but then I had to stop due to chronic pain and torn cartliges and detereoration in my joints and muscles, once I stopped all the bad symtoms gradually came back again, so yes you guys are correct excericise does wonders but not just regular excercise it needs to be done everyday for many month before I find it gave results and it needs to be maintained for the rest of my life which is hard work. However I now feel motivated enough thanks to you guys to try and get back in to it especially after you guys confirmed the benefits.
 
Also in addition to exercise for brain repair consider looking into supplementing with alpha lipoic acid and acetyl-l-cartnitine. To treat your cartilge and joint problems look into glutamine and chondroitin.
Things like gingko biloba and fish oil would probably benefit you greatly also.
 
Some great advice, keep them coming please...

I do in fact take fish oil capsules along with green lip muscle powder and Glucosamine and chondroitin almost everyday for a few years now, but I had not heard of alpha lipoic acid and acetyl-l-cartnitine and I will be definetly getting some soon. Thanks.

Also worth mentioning I no longer use recreational drugs since the overdose 9 years ago, mainly due to the chemical sensitivity Ive been stuck which causes adverse reactions towards those substances.
 
You guys are definetly pro because your suggestions in regards to excercise was a miracle cure in the past for some of my symptoms.

Even though I have lost my ability to sweat due to my damaged Autonomic System after excercising religiously every day for 5 months I found that at the end of that 5 months I began to sweat a little bit and some of my fevers reduced, it was very exciting, but then I had to stop due to chronic pain and torn cartliges and detereoration in my joints and muscles, once I stopped all the bad symtoms gradually came back again, so yes you guys are correct excericise does wonders but not just regular excercise it needs to be done everyday for many month before I find it gave results and it needs to be maintained for the rest of my life which is hard work. However I now feel motivated enough thanks to you guys to try and get back in to it especially after you guys confirmed the benefits.

I would recommend swimming (literal, not SWIMming;) ). As its low impact it wouldn't be very hard on the joints and being in water (preferably cool) would help avoid the chance of overheating due to your problems with sweating. Not to mention it works the largest amount of muscle groups of any commonly performed exercise. Cycling & elliptical machines are pretty low impact as well. Good luck!
 
im no expert, so at the risk of being wrong:

piracetam? as it has no agonistic or inhibitory effect on synaptic action. the increased blood-flow in the brain (especially if taken before excercise) and the general increased neuron excitability may help in aiding your brain restore a balance.

if one of the experts here can confirm whether it would be sufficiently effective as such?


edit: i do agree with vortex30 post hereunder that healthy diet and excercise should be ones cornerstone, but carefully supplementing this with a nootropic or more exotic antioxidants may aid the process. though it is much in the same manner as multivitamins, which do not replace or exempt one from a good diet
i would refrain from using any synaptic agonists or inhibitors, personally.
 
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Call me old fashioned, but I think a really healthy diet full of vitamins is going to work wonders over nootropics and SSRIs and 'drugs'. I guess its fun to theorize, but no offense to the OP, you sound like you're in QUITE poor health and have been for some time. I'm not sure adding foreign chemicals to the mix is really going to do you much good. I'm sure there will some day be discovered a wonderful cure drug to your condition, but our speculating over different nootropics, LSD of all choices (if anything LSD is responsible for most my serotonergic receptor damage), sounds like risky business over simply doing everything you can to improve your health in a natural way.

But I realize the OP is looking for all possible options, so I'll digress of course and say keep 'em coming, that's all just my POV and what has been working for me personally with healing my brain.

Swimming is a great idea for exercise! Don't exercise EVERYDAY by the way, non-stop, no breaks, that's why your body seemed to get so worn down. 4-5x a week you should notice significant improvements and your body won't get worn out, so you can keep it up forever/much longer than 5 months.
 
Call me old fashioned, but I think a really healthy diet full of vitamins is going to work wonders.

Your thinking on the same path as I did when I first developed this condition as vitamins were the first avenue I took in an attempt to repair the damage, I had so much faith in vitamins and a good diet that I went all out spending every cent I got on vitamins, minerals and fruits. I began drinking mangosteen, noni juice, and growing my own wheatgrass and then extracting the juices from it along with fresh squeezed fruits and vegetables everyday. I trialled a variety of detox and liver cleansing products, I was so desperate to get my life back that I kept the routine of a vitamin enriched diet everyday for several years but eventually I decided to call it quits when I didnt notice any improvement in my condition, I felt healthier and energetic but my disability and symptoms remained, or maybe I needed a more specific selection of vitamins to target damaged areas ?
 
^ do you mind if I ask how much amp and mdma you took? also, did you use drugs extensively prior to this incident?

have you tried Rhodiola/Ashwagandha?
 
Ask anything you like, afterall I'm not going to get the help I need by holding back. Prior to the incident I had been using drugs for 5 years almost every weekend at some club or rave party and I had never had any bad reactions previously. It was just that one time was enough to ruin my life.

Its been 9 years but looking back on journals I have documented the substances I took that day consisted of one point of pure meth, 1 white ectacy tablet with a "Pikachu" logo (I recall they were really nice MDMA buzz) and 1 green tablet containing MDA with a "Apple Macintosh" logo. I had the meth and pikachus before but the mda pill was a new batch and my friends said it made them feel weird. So I suspected that was the culprit but later realized maybe it was the combination of all of them or even other factors like loss of electrolytes from overdancing the night before or sexual activity during the overdose which complicated the outcome.

I have not yet tried Rhodiola/Ashwagandha but I would be willing to if you feel they are of benefit in what way ?
 
I think racetams could useful cause they are supposed to help regenerating brain neuronal tissue, in particular aniracetams, for it also has an anxiolitic profile that you could benefit from.

If I'm not wrong you wrote about your condition in the dark side, or was it another guy? But I'm quite sure, since your problem is quite peculiar.
So if it's you I remember you talked about hypertensive crysis other than hypertermia, and then I'd strongly suggest you to look into a vasodilator like arginine (don't know if I can name a specific product) that would surely help your cardiovascular system, and maybe (but this is a completely unmotivated guess) your sweat system.

Also I don't think increasing neurotransmitters would be a good idea like you say, probably your receptors are hypersensible so if ever they could benefit from 5-ht antagonists, or a diet that is poor in tryptophan and 5-htp.

Anyway I'm not a medic so take everything I say cum grano salis. But (again assuming you are the guy I remember reading of) I'm glad now you got a different perspective and you are determined to improve your situation, which is something that I'm sure after 9 years of hell is incredibly hard. Keep on!
 
That was awesome advice, I hadnt even considered nootropics as an option, having a quick look online they seem to be banned in Australia unless I can find a prescription version.

Yea I had posted in the dark side once, suprised you still remembered, the problems with hypertension are a symptoms of the Autonomic Dysfunction, specifically the Postural Hypertension that I have and are easily managed with betablockers which I take everyday, but I would also like to look further into arginine. Thanks for your post.
 
Well I got some very good memory ;)

Nootropics are easily available online and can be sent you disguised as the usual "incense", whatever. If you like you can PM me your email and I'm gonna give you some source. I say e-mail cause I can't answer PMs yet.
Also arginine is a very worthwhile supplement, I found it useful for some non-concerning but very annoying heart issues I developed after using meph (a very responible use I might add, but that stuff is nasty), something sooner or later I'll take the time to share on the meph thread.

I'm glad if this can help you somehow!
 
Is piracetam banned in AUS? if not, you could try it, as its well tolerated and has a very high LD50 (i.e. its safe to experiment with).

Choline may help as well

In terms of trying to increase 5-HT and reduce dopamine, 5-HTP has been documented to have that effect on the body's metabolic pathways. I don't know about how 5-HTP affects thermo-regulation of the body, but I could do some research.
 
High dose Inositol ?

Inositol and a number of its mono and polyphosphates function as the basis for a number of signaling and secondary messenger molecules. They are involved in a number of biological processes, including:
Insulin signal transduction[3]
Cytoskeleton assembly
Nerve guidance (Epsin)
Intracellular calcium (Ca2+) concentration control [4]
Cell membrane potential maintenance[citation needed]
Serotonin activity modulation
Breakdown of fats and reducing blood cholesterol[citation needed]
Gene expression[5][6]
 
Ask anything you like, afterall I'm not going to get the help I need by holding back. Prior to the incident I had been using drugs for 5 years almost every weekend at some club or rave party and I had never had any bad reactions previously. It was just that one time was enough to ruin my life.

Its been 9 years but looking back on journals I have documented the substances I took that day consisted of one point of pure meth, 1 white ectacy tablet with a "Pikachu" logo (I recall they were really nice MDMA buzz) and 1 green tablet containing MDA with a "Apple Macintosh" logo. I had the meth and pikachus before but the mda pill was a new batch and my friends said it made them feel weird. So I suspected that was the culprit but later realized maybe it was the combination of all of them or even other factors like loss of electrolytes from overdancing the night before or sexual activity during the overdose which complicated the outcome.

I have not yet tried Rhodiola/Ashwagandha but I would be willing to if you feel they are of benefit in what way ?

I've had no luck whatsoever with Ashwagandha, but awesome benefits from Rhodiola. I almost gave up on Rhodiola as well, after trying the GNC stuff and some pills from our natural foods grocery store. There's a lot of trashy herbal products I guess. Finally, read about a type of Rhodiola called MBS-13, it's found in two brands, so I bought the "Mind Body & Spirit" brand. I'm totally in shape the following AM, no jitters, basically amplifies anything you put in your brain, safely and effectively. Even makes my mood better.
 
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