what benzos does grapfruit juice potentiate?

[kokaino]

damn temaze if one of the ones I often use. might be gettin 20 valiums later tonight. this time im gunna wait till tommorow than taken em an hr after drinking GFJ. the store near by has a mix of pink & white
the pink & white ones are the only ones that work ah?
Ive onyl seen the ones that are kinda white in colour. like a very light colour. cant remember exactly. but it wasnt straight white. just a light colour
im sure they have yellow & maybe orange too

Yeah, unfortunately grapefruit juice will not potentiate temazepam. It has to do with the way the 3-hydroxy benzos (temazepam, lorazepam, lormetazepam, oxazepam) are metabolized (the route they take to get metabolized, actually). All other benzos are metabolized in a certain way that allows GFJ to potentiate them, while these benzos (including temazepam) are metabolized by conjugation and so GFJ has no effect on them. But Valium can be potentiated by GFJ for sure.

As far as I know, it has to be the white variety of grapefruit juice. The pink GFJ does not work or you have to drink like 2-3 times the amount that you'd drink if it was white GFJ.

 

[kokaino]

Would grapefruit juice potentiate thienodiazepines such at etizolam?

Yes, it will potentiate it!

 

[Anon54]

Sorry to bump this thread but does anyone know how much white GFJ ya need to drink. I have a large bottle 1.5L. should that get me 3 500mL doses?

 

[Pjkt2501]

I imagine that would be adequate, yes. I can't see you needing a gallon of the stuff just to inhibit one enzyme for a bit...

 

[Anon54]

One psychoactive drug that grapefruit juice is known to affect is valium (diazepam). In a paper by Ozdemir in the European Journal of Drug Metabolism and Pharmacokinetics in 1998, they found that 250ml of grapefruit increased the peak concentration by 50% and increased the time to peak from 1.5 hours to 2 hours.

that was from wikipedia.
& ive been drinking 500mL of that crap when ive only really need half that amount. that's good cuz GFJ dont taste real good

 

[OnCloud9]

Thanks kokaino!

I just tried grapefruit potentiation yesterday and the K pins kicked in faster and maybe a little stronger as I was more sedated.

 

[PillJoy]

hey anon -
i also do not love the taste of GFJ - on occassion when i justcan't stomach enuf to make it worth while i add some ginger ale - just enuf to cover the bitter. no sign of diminishing it potentiating effect... [affect? i make myself crazy} IME
in any case, just throwin my suggestion out there - hope its helpful to yu or someone

 

[Anon54]

GFJ potentiates almost all benzodiazepines. The only ones that aren't potentiated by GFJ are the 3-hydroxy family of benzos. These benzo's are temazepam, lorazepam, lormetazepam, oxazepam, and a couple of other more rare benzodiazepines that belong to the same family.

are u sure this info is correct. I just drank some GFJ before taking 80mg of temazepam & 60mg valium so hopefully it'll also make the temazepam stronger because usually i dont feel much at even the high dose of benzos ive taken. i'll wait & see. I drank the GFJ 45ming before.
Does anyone have any sources saying how long u have to wait after drinking the GFJ to dose?
http://www.marinmedicalsociety.org/magazine/articles/?articleid=434

Benzodiazepines, especially diazepam and temazepam, may have increased blood levels and augmented effects when taken with grapefruit juice, especially in the elderly.

 

[effie]

No sources (and no time to look, sorry! Maybe later this evening ) but half an hour has always worked in my experience. Depends if you drink it on an empty stomach or not though..

 

[shreddedlettuce]

GFJ potentiates almost all benzodiazepines. The only ones that aren't potentiated by GFJ are the 3-hydroxy family of benzos. These benzo's are temazepam, lorazepam, lormetazepam, oxazepam, and a couple of other more rare benzodiazepines that belong to the same family.

Not calling you out kokaino, but could you put the following into layman's terms for me....thx

INTERACTIONS
Grapefruit juice has been found to increase the bio-availability of certain drugs (those metabolised by the cytochrome P450 3A4 enzyme), by inhibiting their metabolism in the liver and gut. Because Oxazepam might potentially be affected, patients taking this are advised not to drink grapefruit juice, as potentially serious adverse effects may occur.


I'm a bit confused now.

 

[Pjkt2501]

It means that the GFJ may make the med stronger, and they don't want you to get more effect from your meds. Such is my interpretation.

 

[Tommyboy]

GFJ potentiates almost all benzodiazepines. The only ones that aren't potentiated by GFJ are temazepam, lorazepam, lormetazepam, oxazepam, and a couple of other more rare benzodiazepines that belong to the same family.

Not calling you out kokaino, but could you put the following into layman's terms for me....thx

INTERACTIONS
Grapefruit juice has been found to increase the bio-availability of certain drugs (those metabolised by the cytochrome P450 3A4 enzyme), by inhibiting their metabolism in the liver and gut. Because Oxazepam might potentially be affected, patients taking this are advised not to drink grapefruit juice, as potentially serious adverse effects may occur.


I'm a bit confused now.

I'm not sure if you meant his quote, or the stuff you wrote below it, but for all intents and purposes I cut out the part of the quote that you don't need. As for what you wrote below it, certain drugs that are metabolized (broken down) by the same liver enzymes that metabolize certain benzos will prevent the benzos from being broken down at the normal rate at which they are usually broken down. The enzymes are busy breaking down the other drug, so can't break down the benzos as efficiently as usual, causing the benzo to last a little longer. The benzos that are not effected by this are the ones that kokaino listed.

 

[kokaino]

are u sure this info is correct. I just drank some GFJ before taking 80mg of temazepam & 60mg valium so hopefully it'll also make the temazepam stronger because usually i dont feel much at even the high dose of benzos ive taken. i'll wait & see. I drank the GFJ 45ming before.
Does anyone have any sources saying how long u have to wait after drinking the GFJ to dose?
http://www.marinmedicalsociety.org/magazine/articles/?articleid=434

I am very sure of the info I gave out. The article is wrong in claiming that GFJ potentiates temazepam. It is impossible based on the way temazepam is metabolized.
GFJ potentiates (or increases levels of) most benzos in your system, making them stronger. The exception is the 3-hydroxy benzos (temazepam, lormetazepam, lorazepam, and oxazepam) because they are metabolized through conjugation with glucuronide and demethylation, unlike most other benzos.

 

[shreddedlettuce]

The exception is the 3-hydroxy benzos (temazepam, lormetazepam, lorazepam, and oxazepam) because they are metabolized through conjugation with glucuronide and demethylation, unlike most other benzos.

This is what is confusing...regarding oxazepam.
Kokaino is saying that oxazepam is not affected by GFJ but manufacturer says it is. See link below.

http://home.intekom.com/pharm/lennon/purata.html

 

[mgrady3]

I feel like the warning may be there just to cover their asses - one problem is that the potentiation affect is pretty subjective as you can see thetre has been disagreement on which benzos are potentiated. Some people feel no differing affects for klonopin, some people definitely do.

I've come to understand that 3-hydroxy benzos are not affected, of which oxazepam belongs. I personally only researched temazepam as I was currently scripted for it, but most sites listed that it was metabolized hepatically and listed CYP3A4 as one of the enzymes responsible. This initially makes it seem like temaepam should be potentiated b ut as others have described the 3-hydroxy benzos have a more complicated metabolic path such that inhibition of CYP3A4 has little to no potentiation effects. Thus the Oxazepam listings may say to avoid grapefruit juice simply because 3a4 is one of the enzymes it uses however in reality 3a4 inhibition is not going to do anything when it comes to the metabolism of oxazepam

For those that want to read a bit more in depth - this article explains a little bit about the metabolism of 14 different benzos but its a bit dense
http://dmd.aspetjournals.org/content/37/2/345.full

They do mention that 3a4 primarily works via "3-hydroxylayion" [i'm assuming that's a typo and they mean 3-hydoxylation] So you can look at it in terms of the 3a4 skipping over the benzos that already have a hydroxy group at the 3 position - maybe that's a gross oversimplification though.

 

[shreddedlettuce]

Thanks mgrady3.
Not confused anymore

 

[daveykronick]

In my experience, white grapefruit juice potenciates lorazepam and alprazolam. White grapefruit juice did not make clonazepam any more effective for me, and made diazepam maybe slightly more effective. I noticed it most with alprazolam and a little bit with lorazepam..