candy crew
Greenlighter
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What are the new research opioids out now
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BDD Moderators: Keif’ Richards
What are the new opioids out now
- Thread starter candy crew
- Start date
In terms of stuff that's "out now"?
The closest thing to new opioids would be, I guess, nitazenes. There are similar in some ways to fentanyl in that there are several analogues and they are extremely potent. Scientifically speaking, I believe nitazenes range from ultra-potent to 'bioweapon'.
It's a damn shame that we haven't seen some nice opioid RCs in the way that we've seen billions of benzos. It's also a shame that when we do get something new, it's often strong enough to kill you if you look at it the wrong way.
I personally think O-DSMT is a great RC opioid. It's just a bit weak for me now, sadly.
The closest thing to new opioids would be, I guess, nitazenes. There are similar in some ways to fentanyl in that there are several analogues and they are extremely potent. Scientifically speaking, I believe nitazenes range from ultra-potent to 'bioweapon'.
It's a damn shame that we haven't seen some nice opioid RCs in the way that we've seen billions of benzos. It's also a shame that when we do get something new, it's often strong enough to kill you if you look at it the wrong way.
I personally think O-DSMT is a great RC opioid. It's just a bit weak for me now, sadly.
I wonder why too it’s a shame why we can’t get things like ODMST , or morphine heroin codeine analogues etc I mean there is 1p lsd , 1cb lsd etc why we can’t have 1p morphine , you get my point. The only thing we have is 7OH etc but this isn’t RC at all it’s a “natural” alkaloid
HeadphonesandLSD
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The problem is all the worthwhile euphoric true opioids/opiates were some of the first drugs isolated during the late 1800s-early/mid-1900s. Many of them were already banned by name in western countries long before we got strict drug control in the late 1960s. The market shifted from legally sourced old opioids to fent. analogs in the late 2010s because those were easy to ship because they're so powerful by weight. We don't even have real heroin on the streets of America anymore and haven't for some time. The people that would buy it have already accepted fent and its analogs because they're willing to consume any opioid to starve off withdrawals. The legal channels have been blocked because the pharma companies took a lot of heat for knowingly addicting and killing 100s of millions of people.
Selling a euphoric true opioid is a sure fire way to get a huge target on your back. Selling fent. is semi-tolerated because it isn't addicting new users. It's only killing existing users. Which no one cares about anyway. Well at least not beyond making a profit off of them through bupe and methadone (which the pharma companies and Government has been doing for a long time. They make far more money off of those two substances than they made from writing prescriptions for oxycodone).
The market for opioids is controlled top to bottom. Multiple organizations would come out of the woodwork to bury you if you tried to enter the market with a new euphoric and semi-safe opioid. We've already seen this happen a few times in recent history.
The only reason stuff like 7-OH is tolerated is because it's derived from Kratom and we'll likely see a sweeping ban of it and kratom itself soon because it's cutting too deeply into the profits being raked in by the pharma industry/Government(s). I'm surprised it has been allowed to stay on the market as long as it has.
If you think it isn't possible to take a drug off the market overnight I invite you to research what happened with MXE. A substance everyone loved that was mostly safe, cheap and popular with all sorts of types of drug users. A substance that no one will dare to provide now despite the fact that anyone that did could charge any amount of money they wanted for it and make massive profits even off a small synth sold to enthusiasts.
I am shocked heroin exists at all anymore in non-American markets (aside from Asia at least).
The opioid wave of the late 90s-early 2000s in America wasn't a new phenomenon by the way. In western nations we've seen it happen multiple times since late 1800s. Opioids would be freely available and cheap. Then there would be an outcry to ban them. They'd be tightly controlled and removed from the market. A small expensive controlled market would be allowed to profit off existing addicts. As those addicts aged out opioids would vanish for about a generation. Then they'd be re-introduced to the market again and a new generation would get addicted. Rinse and repeat. We saw this in Germany. We saw this in America multiple times (three since about 1890). We're currently in the tightly controlled phase. Assuming America holds together as a nation we'll probably see the next golden age of opioids around 2040-2050. It seems to come and go in 20-30 year cycles.
There was a time not long ago when no vendor would dare sell opioid RCs. Partly because there was little profit in it (pharma opioids were freely available and cheap along with real heroin being on the market). Now the vendors are willing to sell anything. But they still won't put out worthwhile opioid RCs or even well known opioids that could be cheaply produced. There is a good reason for this. They know better than to go up against the cartel and pharma companies that have controlled the market for a long time.
If it wasn't a controlled market you should be able to buy morphine, opium, oxycodone, oxymorphone, hydromorphone, diamorphine and even stuff like 6-MAM cheap and any time you wanted. There is a large market willing to pay any price for these substances. Yet they remain unavailable. Even people with access to some of them diverted from legal channels can only buy them maybe 1-2 weeks out of any given month. The market is controlled. That's just the reality of the situation.
HeadphonesandLSD
Bluelighter
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For what it's worth. There are interesting substances in research right now. PZM21 is one I've had my eye on for a long time.
But you'll probably never get to taste it yourself I'm afraid. Unless you have access to a lab.
For the user looking to maintain a supply of opioids/opiates for themself your best bet at the moment is probably growing your own. But you'll run into the same problem I described above. The seeds you need are also tightly controlled and becoming much harder for the regular person to purchase. It isn't as easy as going to your local garden center anymore. Since proper pods vanished from the market so have those strains of the poppy and their seeds. The seeds you can find are often radiated before being sold on the open market to ensure no one gets any bright ideas about growing their own. But this isn't a problem with just opium poppies it's widespread and effects most crops people used to grow in their own gardens (they want you buying starter plants and/or seeds every year now).
Most of the poppies on the market in western countries will only produce Thebaine now.
But you'll probably never get to taste it yourself I'm afraid. Unless you have access to a lab.
For the user looking to maintain a supply of opioids/opiates for themself your best bet at the moment is probably growing your own. But you'll run into the same problem I described above. The seeds you need are also tightly controlled and becoming much harder for the regular person to purchase. It isn't as easy as going to your local garden center anymore. Since proper pods vanished from the market so have those strains of the poppy and their seeds. The seeds you can find are often radiated before being sold on the open market to ensure no one gets any bright ideas about growing their own. But this isn't a problem with just opium poppies it's widespread and effects most crops people used to grow in their own gardens (they want you buying starter plants and/or seeds every year now).
Most of the poppies on the market in western countries will only produce Thebaine now.
Im using speech to text. Pl3ase forgive any errors in spelling or grammar
Okay, so here's the issue with this thread. The problem ISIS extremely vague. First of all, you ask a question that is so broad that the answers are really just they can be so varied that it's going to be impossible to actually have any kind of a real in depth objective discussion about these things and so right now I'm going to leave it open, but I think we need to trim this down, maybe ask some questions that are a little bit more pointed and directed.
If this is something that you're truly interested in. I would advise you to approach it from a different direction. You would be better off just familiarizing yourself with the litany of different opioids that are where have been on the market or on the illicit market, you learn about them, and you figure out what are the similarities, what are the differences?
If we can't make this about a specific substance or class of substances so that we can have an actual discussion, we're gonna have to move this over to drug culture because it's just too vague.And it's not necessarily concerned with harm reduction , as this is more a curiosity.
I will circle back in just a little bit
Okay, so here's the issue with this thread. The problem ISIS extremely vague. First of all, you ask a question that is so broad that the answers are really just they can be so varied that it's going to be impossible to actually have any kind of a real in depth objective discussion about these things and so right now I'm going to leave it open, but I think we need to trim this down, maybe ask some questions that are a little bit more pointed and directed.
If this is something that you're truly interested in. I would advise you to approach it from a different direction. You would be better off just familiarizing yourself with the litany of different opioids that are where have been on the market or on the illicit market, you learn about them, and you figure out what are the similarities, what are the differences?
If we can't make this about a specific substance or class of substances so that we can have an actual discussion, we're gonna have to move this over to drug culture because it's just too vague.And it's not necessarily concerned with harm reduction , as this is more a curiosity.
I will circle back in just a little bit
From Wikipedia,
SR-17018, also known informally as SR-17or just SR, is an atypical opioid receptor modulator with unusual actions and effects.[2][3][4][5][6] It acts as a biased partial agonistof the μ-opioid receptor (MOR), showing strong selectivity for activation of G proteinsignaling over β-arrestin2 recruitment.[3][6]
SR-17018
Unlike conventional opioids such as morphine and fentanyl, SR-17018 produces robust analgesic effects in rodents with very little respiratory depression and with much less analgesic tolerance.[3][4][5][7][8]Moreover, substitution of conventional opioids like morphine with SR-17018 can reverse analgesic tolerance and suppress withdrawal symptoms in rodents.[4][7]However, conflicting findings exist in terms of analgesic tolerance and respiratory depression.[7][9] The drug has not been formally studied in humans.[10] implying an unknown safety profile.
SR-17018 was first described in the scientific literature by Laura Bohn and colleagues in 2017.[2][3] It was encountered online as a novel designer drug by 2023.[11][1]Subsequently, discussion of SR-17018 on the social media website Reddit dramatically increased in 2024.[1] Although technically a designer opioid, SR-17018 is said to have very different effects from other opioids, for instance producing minimal euphoria.[1]Rather than being used recreationally itself, SR-17018 is typically employed by users to prevent opioid withdrawal symptoms and facilitate opioid discontinuation in the context of opioid dependence.[
SR-17018, also known informally as SR-17or just SR, is an atypical opioid receptor modulator with unusual actions and effects.[2][3][4][5][6] It acts as a biased partial agonistof the μ-opioid receptor (MOR), showing strong selectivity for activation of G proteinsignaling over β-arrestin2 recruitment.[3][6]
| Other names | SR17018; SR-17; SR17; SR |
|---|---|
| Drug class | μ-Opioid receptorbiased partial agonist; Analgesic; Opioid replacement |
| Onset of action | 1–2 hours[1] |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| ChEMBL | |
| PDB ligand | |
| CompTox Dashboard(EPA) | |
| Formula | C19H18Cl3N3O |
| Molar mass | 410.72 g·mol−1 |
| 3D model (JSmol) | |
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SR-17018 was first described in the scientific literature by Laura Bohn and colleagues in 2017.[2][3] It was encountered online as a novel designer drug by 2023.[11][1]Subsequently, discussion of SR-17018 on the social media website Reddit dramatically increased in 2024.[1] Although technically a designer opioid, SR-17018 is said to have very different effects from other opioids, for instance producing minimal euphoria.[1]Rather than being used recreationally itself, SR-17018 is typically employed by users to prevent opioid withdrawal symptoms and facilitate opioid discontinuation in the context of opioid dependence.[
From wiki again,
SR-14968 is a drug which acts as a biased agonist at the μ-opioid receptor, selectivefor activation of the G-protein signalling pathway over β-arrestin 2 recruitment. It is closely related to other compounds such as SR-17018 although it is more potent and is a fully efficacious agonist. SR-14968 shows robust biased agonist activity in vitro, but in animal studies in vivo behaves more like a typical opioid agonist and will still produce respiratory suppression at higher doses although it has a wider safety profile compared to fentanyl. Compounds of this class are under development as potential analgesic medications with lower risk of overdose and drug dependence compared to traditional opioid drugs.[1][2][3][4][5] SR-14968 was encountered online as a novel designer drug in 2025.[6]
SR-14968
SR-14968 is a drug which acts as a biased agonist at the μ-opioid receptor, selectivefor activation of the G-protein signalling pathway over β-arrestin 2 recruitment. It is closely related to other compounds such as SR-17018 although it is more potent and is a fully efficacious agonist. SR-14968 shows robust biased agonist activity in vitro, but in animal studies in vivo behaves more like a typical opioid agonist and will still produce respiratory suppression at higher doses although it has a wider safety profile compared to fentanyl. Compounds of this class are under development as potential analgesic medications with lower risk of overdose and drug dependence compared to traditional opioid drugs.[1][2][3][4][5] SR-14968 was encountered online as a novel designer drug in 2025.[6]
| Other names | SR14968 |
|---|---|
| Drug class | μ-Opioid receptorbiased agonist; Analgesic |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| Formula | C20H20BrCl2N3O |
| Molar mass | 469.20 g·mol−1 |
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[/th]This one is more easily sourced. I heard it sucks though. I think that’s bc everyone’s tolerance is screwed by fent. I can get real brown H about 3 times a year still and my fent friends can’t feel it, but they still do it bc they don’t have to redose ever two hours. People forget heroin had legs 3x longer than fent. There’s more of these like SR 16435 and BU72, just google this one and at the bottom of its wiki page it will give you links to other SR opiates. I don’t want to spam the thread with them but there are a lot, and they are just now being researched. You can go down a rabbit hole researching these.
PenguinWithNapalm
Bluelighter
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IC-26 Methiodone is an interesting one. It’s an analogue of methadone
en.wikipedia.org
IC-26 - Wikipedia
Stassi202
Bluelighter
You should be getting a catalog in the mail
candy crew
Greenlighter
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- Feb 24, 2026
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What opioid is this
TheLightBringer
Bluelighter
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- May 25, 2022
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- 673
How new is new?
Id say probably IC-26, DPP-26 and the Bezitramide analogues like Etodezitramide are the most recent ones ive seen discussed.
Probably some -Orphine opioids as well but a lot of them are crap. Avoid the hyper potent stuff
Id say probably IC-26, DPP-26 and the Bezitramide analogues like Etodezitramide are the most recent ones ive seen discussed.
Probably some -Orphine opioids as well but a lot of them are crap. Avoid the hyper potent stuff
Just Google it then go to its wiki page. Then at the bottom of the page it’ll give you several links to other ones being researched. I just think we are going about this the wrong way. Things needed to be done about the epidemic, but the government is being too strict, and it’s opened a vacuum for all this other shit to come out and be made that’s so much more addictive and harder to come off of. It’s sad to see. I wish RFK being a former heroin addict himself would spend more time with this on reform than he does with the dye in our cereal. Sorry for going off topic.
Tetrapharmakos
Greenlighter
I don't think SR-14 neccesarily sucks. I mean it probably sucks for recreational use. But it seems to be useful for someone taking nitazenes or fentanyl or whatever who want something cheap and long lasting to stop withdrawals and make for easy tapering.
IMO it isn't required though if you can get SR-17. SR-17 is way weaker with a dose ceiling but IMO it can be used to effectively taper and detox off any opiate without dealing with any withdrawals if used correctly. I used to be pretty unconfident in that but at this point I've seen people I know personally use it for methadone, fent, and other opiates and read enough user reports to be very confident in it.
It just sounds too good to be true and yet ... I've seen over a dozen independent anecdotal accounts like the above.
It'd be one of the biggest game changers if it were confirmed legit and made somewhat available. I can also imagine that the rush to stamp this out of existence coming from extremely powerful pharmaceutical industries would be unlike anything previously seen. It currently seems hard to find but I think I'll have to go full mission impossible mode at least once to see whether I can get some. If it works as people are saying, it'd be history in the making. (Mostly referring to SR-17018 here.)