Really have no idea how this is going to play out, I do not think the DEA/Federal Government is going to shut it down though. Way too few resources right now, and polling shows that attitudes are shifting. The President has been pretty responsive to polls (example: Gay Marriage, Ending DADT, Lilly Ledbetter, acknowledging the people's call for higher taxes on the wealthy) and I doubt he wants to get involved, especially considering the fact that despite predictions, large amounts of young voters came out again.
Really, I think more and more states are going to start doing this. I actually would not be surprised if the President comes out in support of Medical Marijuana and a change in the classification of the drug (moving it to a Class 3 or something).. if the country keeps moving towards legalization then even that maybe. I really do not think the United States is that far away from legalization of Marijuana.. especially if we get the right people in office. The Senate would be pretty responsive to it right now, the House not so much.
As for the UN, its an important body but they cannot dictate drug laws inside the United States. Some of this fear of the UN seems like its coming right out of the early 1950s.. pretty silly.
Over the last 20 years, especially the last 10 or so, American attitudes towards many things have rapidly been softening. The United States is changing rapidly and many are starting to adopt a pretty progressive attitude. I wouldn't be surprised if the US becomes one of the leaders when it comes to legalizing Marijuana.