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Weed and 5htp

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StereoLogic

Bluelighter
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Jun 23, 2009
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I've read a little about people experimenting and getting mixed reviews of using marijuana and 5htp together. So I decided to experiment a little. Personally I don't understand how the chemicals even work together... as serotonin and marijuana do not seem to go hand in hand.

First night, me and the lady tried 300mg ( we normally take 1x100mg 5htp before bed) and then about 30 minutes later smoking a few bowls in a backyard with some friends. I have to say if there was anything I actually noticed, it wasn't so clear that I could pin it on the 5htp. I was maybe, and only maybe, a little more clear headed.

Last night, tried it a little different. Took 500mg this time, and I wont ever ever ever ever suggest this to anyone. Smoked a few hookah bowls with shisha and pot mixed in. Maybe smoked for like an hour, two coals. ( ps this is a great remedy for people who have an issue with not making your house/room smell like pot ) Felt my normal high kick in... then started to feel a lot higher, a lot faster, and almost too much. Definite music enhancement, much more then normal, but a feeling of uneasyness too. I can actually compare this to codeine and weed. Im that fucking high. I stay up for about 2 hours, listen to music, play video games, starting to feel really uneasy, just kind of gross. So I decide to join my girlfriend in bed, my mind is racing pretty hard, and it takes a little to fall asleep. Eventually I do fall asleep, and I awake a few hours later, high as fuck. Ugh, I havent experienced this for like a decade. It's so uncomfortable at this point, I just feel so gross. I fall asleep for another hour and a half, wake up, still fucking high, and its driving me nuts, my head feels so fucked. I sleep another 2 hours, wake up feeling a little confused, but not high. My stomach is wrenched. I eat a little and all feels okay... maybe just a little weed hangover, also something I havent felt for like a decade. I actually don't want to smoke weed today, and that has to be a first in more then a decade.

I do not in any circumstances suggest this.
 
if i start a regiment of 5-HTP, it will potentiate my pot-smoking for the first week or two (slightly stronger, dreamier feeling) before going back to normal. but i can never take 5-HTP for too long before it starts fucking with my stomach.
 
I don't think there is a connection between 5htp and weed smoking. Weed (I think) acts on a neural system that modulates reward/motivational pathways (the dopamine system) and 5htp may (or may not) boost serotonin levels. I have smoked weed daily for 18 years+ and tried a couple of months on 5htp daily. I wanted to try and boost my serotonin levels (not depressed, just interested to try). 5htp did appear to have some effect in that department, although I can't rule out a placebo effect. I had good sleep, vivid dreams and felt generally more lively from a mental point of view. I suppose my enjoyment of weed was enhanced by the fact I was feeling a little bit sharper anyway from the 5htp, but as for a direct synergy, I doubt it.
Also, I should mention, it is not advisable to use 5htp for more than a couple of months. Your body makes serotonin in several stages from the material in your diet. 5htp jumps a few stages and boosts serotonin around your body (not just in the Raphe Nuclei where the brain stuff originates). The extra seratonin can cause problems in the heart (cardiac fibrosis). Get straight tryptophan, (the basic dietary ingredient which starts the procecess of serotonin manufacture). The body will then only make the required quantity of serotonin it needs and more crucially, where it is needed. There is a self limiting step in the process which is bypassed by 5htp. Trptophan (htp) is now available as a dietary supplement. I have been using it for two months now and it seems to have a simillar effect as 5htp.
Peace - Pipp
 
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thanks for the info, that concludes what i was thinking. I think it wasnt a synergy of the two, but more or less a reaction to too much 5htp. None the less, i don't suggest anyone using this combination, nor mixing 5htp with anything for that matter.
 
Are you sure the effects you describe aren't due to the combination of nicotine and cannabis? Nicotine definitely gives me a more "cerebral' high like you describe.
 
i only use 5htp after a night of rolling
i tried this combo (weed & 5htp) before and it felt that i was in a dreamy state
it made me sleepy and fog like :|
 
For a while, I was taking about 200mg of 5-htp with a couple bowls, because my friends and I were convinced it was making us that much higher, but in a clean way. We would be completely geeked, but not uncomfortable in any way. We did that all the way until we ran out.

I'm pretty sure it's not placebo. I smoke a lot, I'm consistently high every evening, so any change is usually pretty detectable.
 
You would be very surprised how much of an effect weed can have with a placebo. Gave a kid some advil and told him it was valium once, and he was raving about how great and high he was.

Weed is a psych, so you become a lot more prone to believing in a placebo.

I don't think 5htp would work with weed, it doesnt make much sense, as most of the literature I've read doesn't suggest that weed effects your seratonin levels past minute ways.

What is a regular dose of 5htp? Is there a line (OD) or threshold level?
 
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