Misc Weakest binding antidepressant?

[polarthedog]

which anti depressant has the weakest binding affinity to the SERT receptor?

 

[Jabberwocky]

Paroxitine with a binding affinity of 0.13

Zimelidine the most with an affinity of 152 (though I’d never heard of it before)

There is wiki page about SRI’s with all the data including for SSRI’s

 

[polarthedog]

Can you give me a link? Also I think the lower 5e number the stronger it binds

 

[Jabberwocky]

somebody correct me but I really don't think its their affinity which dictates their affectiveness and/or side effects?

this is data you would pull from google/case stadies not BL I would think

 

[negrogesic]

Note that the lower the ki/ec50 value the higher the potency. Thus paroxetine is highly potent.

 

[Jabberwocky]

Note that the lower the ki/ec50 value the higher the potency. Thus paroxetine is highly potent.

My mistake. Info source here. I’ll read more slowly next time https://en.wikipedia.org/wiki/Serotonin_reuptake_inhibitor?wprov=sfti1

 

[polarthedog]

I’m wondering if there an. ANTI depressant that would have a weaker binding affinity than mescaline, so that I could switch to it and trip while I’m weaning off

 

[negrogesic]

I’m wondering if there an. ANTI depressant that would have a weaker binding affinity than mescaline, so that I could switch to it and trip while I’m weaning off

Mescaline binds directly to various serotonin receptors directly as a moderate-high efficacy agonist (and in the micromolar range so it isn't particularly potent) so its very different than most antidepressants, the bulk of which function as reuptake inhibitors or antagonists.

So really is your question then, which is the best antidepressant to be taking if you want to indulge in psychedelics?

 

[polarthedog]

Yes, also I guess which psychedlicmhas the strongest binding affinity

 

[Jabberwocky]

Yes, also I guess which psychedlicmhas the strongest binding affinity

You might find this article interesting as it talks about the binding affinities and subjective effects of 19 different substances. Talks about the relevance of many more receptor types beyond thoae relevent to SERT. Doesn’t answer your question directly though unfortunately.

Correlation Between the Similarity of Reported Subjective Effects, Binding Affinity Profiles and Molecular Structures

Maybe this has already been shared. Apologies if old news However for me it’s an interesting use of natural language processing on trip reports and Principal Component Analysis to examine the connection between psychadelic substance receptor affinity, substance molecular structure, and...

www.bluelight.org