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Pharmacology Want to live longer ? Take Rapamycin.

This thread contains discussion about a Pharmacology-related topic
This is about the most risky way to extend your live imo.
Ok maybe be when your 70 + and have a liberal doc prescribing it.

There sooo many supplements natural/ chemical that suppopsedly extend live.
Melatonin, all the superfoods, vegetarian lifestyle, adaptogenic herbs, smartdrugs.

Dr prescriptions depends where you live but here, Rapamycin def not.
But no dr will prescribe Selegiline, Metformin or L-Carnitine for extanding your live .
For a medical condition yes, for living fitter and longer forget it.
Like a butcher saying you know Vegetarisme is very healthy, you should try.

On the other hand we are polluting the air the most important thing we need,
Water 2-nd most important needed ingredient for the body,
and our soil so basicly everything you eat thats grown in natural soil is polluted.

They even advice people to eat greenhouse food that filter their water. Safer.
And indoor eggs not bio or freerange as PFAS and PAHs rain from the sky.
So inside is healthwise safer. Also use less pesticides grow on rock-wool.
Controlled fertilizer. Maybe Eko use soil hope they have it analyzed before use.

And its true personal witnessed it one good dose of PAHs from nextdoor fire that ingited the PUR.
Result yellowing of leaves of plants and one showing mutations, 6 look like dying 4 allready did.
Yelowing is direct effect of te PAHs. That are in the air abundant anyway ?
But a good hit like with the extinguishing water. Raining it down did, formed actual snowlike flakes.
Thats all needed for sudden death, i inhaled too am i turning yellow yet ?
 
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MTOR also implicated in psychedelics and ketamine.
The OTC supplement Agmatine also works through mTOR (amongst other things)

Agmatine produces antidepressant-like effects by activating AMPA receptors and mTOR signaling
...
These results indicate that the antidepressant-like effect of agmatine in the TST may be dependent on the activation of AMPA and TrkB receptors, PI3K and mTOR signaling as well as inhibition of GSK-3β, and increase in synaptic proteins. The results contribute to elucidate the complex signaling pathways involved in the antidepressant effect of agmatine and reinforce the pivotal role of these molecular targets for antidepressant responses.

https://www.sciencedirect.com/science/article/abs/pii/S0924977X16300074
Agmatine is widely distributed in human tissues, including the brain...
Taken together, these results support the hypothesis that agmatine can act as a ketamine-like compound...

https://www.wjgnet.com/2220-3206/full/v11/i11/981.htm
 
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The OTC supplement Agmatine also works through mTOR (amongst other things)

Doesn't surprise me since it's similar to ketamine. I would have thought it was downstream from NMDA antagonism but ok, AMPA receptor.

Post edited because of confusion.
 
Yes, agmatine seems to interact with NMDA, AMPA, alpha 7 nicotinic ACh, sigma-1, HT1/2A, BDNF, Imidazoline and alpha-2 adrenergic receptors also.
Theres quite a lot going on.
 
This guy wrote about agmatine's ketamine-like psychedelic potential. In the sense that agmatine mimics ketamine with added 5-HT2A activity like the classic psychedelics.
Agmatine is popular as a pre-workout supplement too, I wonder how many of those guys/gals realise what they've got!

 
This guy wrote about agmatine's ketamine-like psychedelic potential. In the sense that agmatine mimics ketamine with added 5-HT2A activity like the classic psychedelics.
Agmatine is popular as a pre-workout supplement too, I wonder how many of those guys/gals realise what they've got!



Wish it was readily available where i'm at
 
I noticed that an alkaloid called Smirnovine [27586-69-2] is hydrolyzed to agmatine.

If you consult the 1996 reference it describes a putative chemical synthesis.

[1] Ryabinin.,Dokl. Akad. Nauk USSR, 61,317 (1948).
[2] Brutko, L. I., Massagetov, P. S., Utkin, L. M. (November 1966). "The alkaloid smirnovine from Astragalus tibetanus". Chemistry of Natural Compounds. 2 (6): 362–362. doi:10.1007/BF00564229.
[3] Benn, M. H., Shustov, G., Shustova, L., Majak, W., Bai, Y., Fairey, N. A. (1 January 1996). "Isolation and Characterization of Two Guanidines from Galega orientalis Lam. Cv. Gale (Fodder Galega)". Journal of Agricultural and Food Chemistry. 44 (9): 2779–2781. doi:10.1021/jf960175l.
 
I found another related article (see my previous post) for shopping ideas:

Wang YS, Shen CY, Jiang JG. Antidepressant active ingredients from herbs and nutraceuticals used in TCM: pharmacological mechanisms and prospects for drug discovery. Pharmacol Res. 2019 Dec;150:104520. doi: 10.1016/j.phrs.2019.104520. Epub 2019 Nov 6. PMID: 31706012.

This article summarizes the work done on the natural products from TCM that have been reported to conceive antidepressant effects in the past two decades, which can be classified according to various mechanisms including increasing synaptic concentrations of monoamines, alleviating the hypothalamic-pituitary-adrenal (HPA) axis dysfunctions, lightening the impairment of neuroplasticity, fighting towards immune and inflammatory dysregulation. The antidepressant active ingredients identified can be generally divided into saponins, flavonoids, alkaloids, polysaccharides and others. Albiflorin, Baicalein, Berberine chloride, beta-Asarone, cannabidiol, Curcumin, Daidzein, Echinocystic acid (EA), Emodin, Ferulic acid, Gastrodin, Genistein, Ginsenoside Rb1, Ginsenoside Rg1, Ginsenoside Rg3, Hederagenin, Hesperidin, Honokiol, Hyperoside, Icariin, Isoliquiritin, Kaempferol, Liquiritin, L-theanine, Magnolol, Paeoniflorin, Piperine, Proanthocyanidin, Puerarin, Quercetin, Resveratrol (trans), Rosmarinic acid, Saikosaponin A, Senegenin, Tetrahydroxystilbene glucoside and Vanillic acid are Specified in this review.
 
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