Speaking very generally, for recreational use, where the comedown is as mild as possible, I'd go for the Vyvanse. Most people prefer amphetamines to methylphenidates (e.g. Ritalin), and Vyvanse provides a smooth, steady, and long-lasting high. Simple Adderall, IR or XR, is much more jumpy, does not last as long, and doesn't have nearly as smooth a comedown as Vyvanse. Now, Dexedrine, IR or Spansule, is somewhere in between. With Vyvanse, you'll get lengthier, and generally more, effect of what you would with Dexedrine, and with a smoother comedown. Thinking of this, I may ask my psychiatrist to try me out on Vyvanse, as I recently jumped from Adderall XR to Ritalin (instant-release), per my request. I was getting burnt out from the Adderall XR, but Vyvanse is so nice and smooth. The only thing is, as mentioned above, you get thirty for thirty days - you want to double up some, then you have to take some days 'off'. That is the drawback for me, for I enjoy controlling my dose very particularly for maximum therapeutic and recreational effect.