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Vitex Agnus

The current study confirmed that VAC methanol extracts had affinity to the μ-opiate receptor. The μ-opiate receptor is the primary action site for β-endorphin in vivo. In future studies, we will determine if similar affinity is found for δ and κ opiate receptor, as has been suggested
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I think finding the affinities for the other opiate receptors would be important here. What is the active(s) opiate alkaloid? That study was poorly written...

Supposedly it increases testosterone, but typically, mu-agonists tend to reduce test levels...

Here is one active, though it doesnt look like an opioid:

imgsrv.fcgi
 
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only way to find out is if u guys try it.

and i dont think mu-agonists reduce test levels :/
 
asecin said:
i dont think mu-agonists reduce test levels :/
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I don't think Sasha Grey should go through the rest of this week without having sex with me. I do know that mu agonists are markedly andro-supressive.
 
I dosed on mu-agonists every day from age 17 to 23. I stopped, and my breakouts got *worse* and I started growing chest hair. Could be a coincidence ;-)

I wonder, do you get tolerant to the andro-suppressive effects?
 
yeh i wish u help me gather more info on this if possible.

i might try it if i can find it tho
 
The Monkey Mantra said:
I wonder, do you get tolerant to the andro-suppressive effects?
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I had a discussion about this very thing with a doctor at a methadone clinic. Naturally, at least in males, there is a partial return to homeostasis, but the system never seems to completely equilibrate itself to baseline levels.

Consider also that high-dose testosterone has depressant effects similar to those of opiates. It turns out that naltrexone blocks the depressant effects of high-dose test. The mechanisms are intrinsically linked, it seems. At the risk of ignoring something obvious, I would guess that there could be a mu-agonist that is at once euphoric and androgenic. It sounds like a wet dream, but if I had to propose one of these ULTIMATE SUPER-MEGA-DRUG OF THE FUTURE things, that would be my entry.
 
A neuroactive steroid with a strong affinity for the MOR? Sounds good...

My guess is that such a drug, if at all possible, would also possess GABAergic properties, like alphalodone:

We conclude that coadministration of alphadolone, but not alphaxalone, with morphine, fentanyl, or oxycodone potentiates antinociception and that this effect is not caused by an increase in sedation.

http://www.anesthesia-analgesia.org/cgi/content/abstract/97/3/798
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Yet, based on the structure one wouldn't think that it would have opioid properties:

Neuroactive_steroids.png


That last one, minaxolone is potentially closer to an opioid. But, I doubt it has little if any affinity for the androgen receptors...
 
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Why is minaxolone closer to an opioid? because it has a tertiary amine? Don't count on it.

When you're talking about non-nitrogenous opioids, the morphine rule goes out the window. There are steroids with opioid affinity. I'd look at things like herkinorin before traditional opioids.

Glucose residues aren't uncommon, either, I don't think in these.
 
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