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Vitamin E to potentiate methadone

Artificial Emotion

Artificial Emotion

Bluelighter
Joined
Jan 19, 2009
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UK (Kent)
I read on a credible website (The Methadone Alliance) that vitamin E releases methadone bound to protein molecules so it can interact with receptors and get you high, meaning it acts as a true potentiator.

My question is this. How many units of vitamin E should I take to potentiate a dose of 300mg methadone?
 
Honestly, at 300mg of methadone, your not going to feel anything. I used to be up there, and you can't feel anything. It sucks. With pot. you'll just end up overdosing eventually. You won't notice though, other people will though. Off to the hospital you go!
 
The answer is in your other post in BDD.

You are basing this, not on NAMA, but on an article by a NAMA member. Her conclusions are half-truths and alarmist at best.

CYP450 inhibitors, urinary alkiners, etc all increase Methadone blood serum levels, just like a protein de-binders like Vitamin E and NSAIDs.

This does not result in a direct increase in the pleasurable effects (euphoria, warmth, etc) of Methadone. It only results in longer duration of effects and heavier sedation. This also raises the risk of respiratory depression and death a lot, especially when these potentiators that raise blood serum levels beyond normal limits are mixed with CNS depressants (anti-Histamines, Benzodiazepines, etc).
 
http://www.methadone.org/downloads/namadocuments/es05basic_pharmacology3.pdf

Here's an extract:

National Alliance of Methadone Advocates said:
Medications that Impact on Methadone Plasma
Concentrations


Some drugs can interact with methadone when it is bound to plasma proteins. As was mentioned above most binding of methadone to plasma proteins is non specific, and this means that many drugs with similar shapes can bind to the same area of the blood protein and knock the methadone molecule out. This can cause a much higher effective blood methadone level, which can be a problem for someone who does not have tolerance or even someone on a low dose of methadone without much of an initial tolerance. Some drugs can knock methadone away from the blood proteins that they are bound to causing a sudden release of methadone to them interact with the opiate receptor. Drugs that can do this are erythromycin, clarithromycin, Vitamin E and many of the NSAIDS (Ibuprofen and Ketoprofen). While the danger is obvious for the individual with a low tolerance these drugs can also have an effect on patients taking a blockade dose with a high tolerance by causing the release of their stored methadone (or buffer) ;and thus destabilizing them. It would probably take a few days to build up the methadone plasma to its initial level.
Click to expand...

I guess it must be incorrect.
 
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I dunno about Vitamin E potentiating Methadone but I do know that Promethazine as well as Fluvoxamine will both greatly increase the serum levels of Methadone in ones bloodstream.
 
I recently overdosed because I took too much promethazine on top of my daily methadone dose. Now i might get booted from my clinic...probably not but it might happen.
 
megawoof said:
wow 300mg of methadone do yu function each day on that im on 75ml a day and find it tough i had regular herion habit too
Click to expand...

Even people consuming the exact same dosage of opioids everyday will require massively different doses of Methadone or Buprenorphine everyday to function properly. A guy at my clinic started out on 600mg Methadone a day. There are many people currently taking grams of Methadone everyday (fast metabolizers, people with a particular genetic defect, people with unusually high opioid habits i.e. dealers, people with access to lots of pharm. opioids, etc).
 
Ever heard of Cat's Claw? Apparenly that is supposed to affect methadone pretty significantly!
 
NAMA is an excellent organization. However, hosting an article written by one of their members doesn't make it backed by the organization itself.

If you are unsatisfied with the information from both sides, e-mail NAMA with a link to the article and ask what their stance is regarding it. That may be the best way to get to the bottom of it.

Post their response if you do :)
 
muie said:
Ever heard of Cat's Claw? Apparenly that is supposed to affect methadone pretty significantly!
Click to expand...

Nope, I don't think it does. I use Cat's Claw quite regularly and haven't noticed much of a difference (that is unless I am uniquely different to most people). I've also obtained from various different sources so I know it wasn't bunk.
 
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i read your reply and am wondering why u don't feel anything w so much methadone. i too take that much or more and am wondering why i can never feel good/high anymore. only once in a great while do i get a very small, short buzz, but thats it...............ps
 
When I was taking 380mg of methadone, I suppose it got me high...

I never tried Vitamin E with methadone, but I would be skeptical that it would provide noticeable potentiation. Cats claw did not seem to work, but promethazine certainly does (to a certain effect, as there is additive CNS depression)...
 
Pure bullshit.

I was on 500mg methadone (for recreational purposes) after a few week of consumption.


It still works in very high dosages just as usual.
 
thelung said:
I recently overdosed because I took too much promethazine on top of my daily methadone dose. Now i might get booted from my clinic...probably not but it might happen.
Click to expand...

ARE you serious?!! I have been faking being sick so I can get outpatient detox meds and one of the meds they give is phenrgan (promethazine), and yes it makes you ALOT higher, I took one just htinking since its an anticholinergic it would increase it.. But ive been having rushing euphoria all day.. I want more :P
I wonder if compazine would work? Does anyone know?

Thanks ,
[email protected]

:D=D;)8o
 
negrogesic said:
When I was taking 380mg of methadone, I suppose it got me high...

I never tried Vitamin E with methadone, but I would be skeptical that it would provide noticeable potentiation. Cats claw did not seem to work, but promethazine certainly does (to a certain effect, as there is additive CNS depression)...
Click to expand...

Are you guys kidding me?? I just recently went up to 80 from 60 and I still get high. I got high when I was on 60. You just need to potentiate it. Use hydroxyzine and phenergan. Youll be high as hell for a while... No need to go up to 300, remember "WHat ever goes up, must come down!" .
:(
sp0r
 
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