Vitamin E to potentiate methadone

[monstanoodle]

I wonder if compazine would work? Does anyone know?

I'm fairly sure it wouldn't. I take it for nausea sometimes.
It is in the same class as Promethazine but that doesn't automatically entitle it to work the same. Shit example, but Loperamide is related to Fentanyl and isn't a strong as a donkey on steroids.

 

[Tchort]

Are you guys kidding me?? I just recently went up to 80 from 60 and I still get high. I got high when I was on 60. You just need to potentiate it. Use hydroxyzine and phenergan. Youll be high as hell for a while... No need to go up to 300, remember "WHat ever goes up, must come down!" .

sp0r

The individual dose necessary for each person is different. Doses up to several grams of Methadone per day are being used currently. There are 2 people at my clinic who attend on the day and time that I do who take larger than average doses (one at 600mg the other just under 1000mg). Everyone is different, and treatment isn't one size fits all.

Some people also require Methadone maintenance or another opioid replacement therapy for the rest of their lives. So, no, what goes up doesn't have to come down.

Some people experience typical opioid effects every day they are on MMT. Many people never experience pleasant or pleasurable effects from MMT, from day 1 to the time they detox or leave the program. For many the first few months of MMT there is a 'transition phase' where the patient experiences pleasurable opioid effects within 90 minutes of dosing, which subsides within an hour or two. But this is definitely not everyone.

 

[PinK~cloud]

Pure bullshit.

I was on 500mg methadone (for recreational purposes) after a few week of consumption.


It still works in very high dosages just as usual.

people get used to their doses and develop a tolerance, chief.

 

[OntarioGuy]

I think alot of people dont need that much methadone,Seems like they're chasing a high.Im sure alot of people do need that much,but most should just get to 100 mg's or so,and tough it out until their tolerance adjusts.I did that with 90 mg's,just because I didnt want to have to taper from the huge doses mentioned in this thread.

 

[sp0r412]

Well my solution to MMT patients wanting to get that high they used to get is to trip off dxm the night before you dose. Seriously if you do about 480mg of dxm and trip at night then go straight to your clinic you will be nodding all day off of your dose.. I promise you. NMDA antagonist do a great job of reseting your tolerances especially for opiates/opiods and methadone. And besides the science of it, I always test my theories on myself, and the dxm potentiation method seems to be the best IMO. Let me know what you guys think,
sp0r412

 

[muie]

Didn't know about the vitamin E & 'sorry' for reviving an old thread (obviously not, why should I be sorry for re-vamping an old thread? Am I to make another thread that's exactly the same?!)

I have yet to try vitamin E though I have some & will def give it a shot b/c unlike dxm its much safer chemical wise, there are many people here who started taking 60mg-90mg everyday to potentiate their dose but many if not most, after a couple of months to 1/2 yrs found themselves taking astronomical doses like 500mg+ around 700-800mg dxm and of co
I'm trying (with very little s potentiate the methadone. Besides taking benzos i've had amobarbital with my dose which is ok but for MMT it does release it faster from your body but nowhere near the level that phenobarbital or st. johns wort do, heavy drinking also. Whenever I take carisoprodol with my methadone dose I feel the best, better then benzos or even barbs which like I said amobarbital is very euphoric and nice but it removes the methadone from the body faster due to the CYP2D6 enzyme inhibition. Some people (interaction charts) say that chloral hydrate is supposed to be 'fatal' mixed with methadone. I also had methadone with clomethiazole up to 800mg in the course of 1 day (I stopped due to stomach irritation after 3 days of using it) and never felt any euphoria though some bluelighters report that clomethiazole mixed with opiates (oral, that's the only way wtih clomethiazole). With clomethiazole I felt some very slight euphoria like with ethaqualone though nothing like 'it blows benzo sarbs & longer and def little stronger euphoria, subtle you still need to look for it but def

What I would like to point out is neither of those drugs potentiate the drug (methadone) they do however potentiat

As someone said anything around 60mg-80mg even if their dose is 100mg-200mg will hold you the rest (over 70mg is to get high on methadone).

Reason for the post is I read Milk Thistle increases the duration of methadone rather than sedating effects. I take it and don't notice very well but the effects seem to last a bit longer.