Limpet_Chicken
Bluelighter
- Joined
- Oct 13, 2005
- Messages
- 6,323
This isn't because it affects me personally, I intend to direct someone to the thread if it takes off and produces any useful input.
But there is a subject (female if it makes a difference) thats been taking at one point, daily, some pretty staggering doses of DOx. DON in particular but afaik, others also. Possibly DOCN (does 2C-CN and the other 2Cx series share the same action?). So much so that I'm staggered tachyphylaxis doesn't set in. Or that they continue to have any effect at all.
I know DOI in particular has some fairly potent inhibitory effects on TNF-alpha release. And given the doses and regularity, daily, in largish quantities (6mg DON plus) whats the likeliehood of a rebound resulting in systemic proinflammatory effects, or generalized cytotoxicity? particularly concerned about damage to the heart. Subject describes burning of the skin (although had also recently been in hospital after a nasty incident, that afaik, involved a Br2 spill. So not sure if this was systemic or limited to the area contacted by bromine, although I think, the former)
But there is a subject (female if it makes a difference) thats been taking at one point, daily, some pretty staggering doses of DOx. DON in particular but afaik, others also. Possibly DOCN (does 2C-CN and the other 2Cx series share the same action?). So much so that I'm staggered tachyphylaxis doesn't set in. Or that they continue to have any effect at all.
I know DOI in particular has some fairly potent inhibitory effects on TNF-alpha release. And given the doses and regularity, daily, in largish quantities (6mg DON plus) whats the likeliehood of a rebound resulting in systemic proinflammatory effects, or generalized cytotoxicity? particularly concerned about damage to the heart. Subject describes burning of the skin (although had also recently been in hospital after a nasty incident, that afaik, involved a Br2 spill. So not sure if this was systemic or limited to the area contacted by bromine, although I think, the former)