Vancouver BC man claims poorly mixed fentanyl results in 'hot spots' which kill.

On Opiophile oxymorphone was considered the most euphoric opioid by far, But it remains to be seen if they will do so. I PRESUME the DEA will be able to obtain satellite footage to gauge if poppies have been grown and harvested within Mexico. I know it virtually died out but if suddenly it's back, I would be asking if it's normal opium poppies, GM opium poppies or oriental poppies (the last two indicating oxymorphone is the intended product).

Heck - someone could most likely just use Google Earth to find them.
 
jied.lse.ac.uk

The Last Harvest? From the US Fentanyl Boom to the Mexican Opium Crisis

For decades, farmers in the most marginalised regions of Mexico have depended for survival on the illicit cultivation of opium poppy for the US heroin market. In 2017 they could earn up to 20,000 pesos ($950–$1,050 dollars) per kilo of opium, which channelled around 19 billion pesos ($1 billion...
jied.lse.ac.uk jied.lse.ac.uk

Actually, considering that the Norman strain (GM opium poppy that produces thebaine and oripavine but no morphine) can be grown in open fields in Tazmania, I would be looking closely to see if some Mexican entrepreneur has gained the right to grow the stuff legally. I imagine someone can easily claim to be growing it to extract a 'pharmaceutical intermediate' and possibly even get government grants for growing in poor areas.

Because their is NO control over oripavine. Thebaine IS mistakenly listed as a UNODC 'drug' even though it fact it's a poison, but orpiavine ISN'T and it's quite feasible to selectively extract it. It's also toxic. Not hugely so, but sufficiently to ensure NOBODY is going to mistake it for a drug.
 
CaptnRon said:
I’m gonna go out on a limb and just say that the reason fent is so prevalent, is that the cartels are making it dirt fucking cheap.

The price margins are huge. For example, you’re paying $25 for a press that literally costs a few cents to make. The bags of fent/fentadope I used to buy from the local open air drug markets by me, are fucking dirt cheap, like 50$ for 16+ bags, and still at that price the cartels are getting filthy rich, and there’s still enough profit for the corner bosses, runners, and dope boys to make money. Or they wouldn’t be out hustling.

The cost of producing quality heroin is ten fold or more than the cost to produce fentanyl/fentalogues. Thus the reason the US market is saturated with fent.

Stay good
Always, fair winds and following seas
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The iron law of prohibition. Truth.
 
O
someguyontheinternet said:
Oh man if the cartels start making oxymorphone 😍
Probably wouldn't be very clean though. But who knows, apparently they make meth decently pure
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Only if they hired the right chemists. Apparently, they can’t even manage proper dosage mix of fent analogues. I highly doubt their chances at decent oxymorphone or hydromorphone synthesis.
 
I
AlsoTapered said:
On Opiophile oxymorphone was considered the most euphoric opioid by far, But it remains to be seen if they will do so. I PRESUME the DEA will be able to obtain satellite footage to gauge if poppies have been grown and harvested within Mexico. I know it virtually died out but if suddenly it's back, I would be asking if it's normal opium poppies, GM opium poppies or oriental poppies (the last two indicating oxymorphone is the intended product).

Heck - someone could most likely just use Google Earth to find them.
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I don’t agree w that, but everyone is different. One that has a big reputation but feels more like low dose DXM
Is levorphanol. And I was prescribed very large dose. Disappointing af.
 
Does the oxymorphone deal with the pain? After all, what we are actually discussing the side-effects.
 
sekio said:
I somehow doubt this. Dealers here don't mix their own "down" (as the local lingo goes). They almost always buy it from their "boss" who probably knows the people distributing the final product on a large scale. It is almost always as homogeneous as possible. (It is not good PR to kill too many customers).
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really hard to get facts on this, but I have seen at least one vid of a local street-level f dealer mixing up fent in a basement suite - trying to relocate.
 
Mjäll said:
No i'm not sure at all. More of an interesting observation of claims than a claim of irrefutable fact.

This is my reference, however; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676998/

Does seem pretty good research, although i am yet to parse the practical details

I do believe based on this research and personal experience that kratom is meaningfully a2 adrenergic agonist. It's a belief that may be challenged and not set in stone. I am attracted to the concept of course.
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That paper shows that kratom alkaloids act as antagonists of alpha2 adrenergic receptors, not agonists.

They function like (the structurally similar) yohimbine, rather than xylazine.

Edit: I'd like to point out this recent thread in NSPD. It contains discussion about a paper looking into the pharmacology of xylazine. They found that it acts as a kappa opioid antagonist, a sigma 1 agonist, and a 5HT7 agonist.

It also makes withdrawals worse, partially by altering adrenergic signaling (which is already a key downstream driver of a lot of withdrawal symptoms).
 
Skorpio said:
That paper shows that kratom alkaloids act as antagonists of alpha2 adrenergic receptors, not agonists.

They function like (the structurally similar) yohimbine, rather than xylazine.

Edit: I'd like to point out this recent thread in NSPD. It contains discussion about a paper looking into the pharmacology of xylazine. They found that it acts as a kappa opioid antagonist, a sigma 1 agonist, and a 5HT7 agonist.

It also makes withdrawals worse, partially by altering adrenergic signaling (which is already a key downstream driver of a lot of withdrawal symptoms).
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You're right! Honestly i didn't even get that far as to looking at the raw data since i'm used to not even finding it. But there it was.

However an interesting detail is that it seems an even stronger antagonist at alpha1 receptor subtypes, which to my understanding have opposite effects. So as far as i understand it could still have net anti-noradrenergic effects. Maybe i'm mistaken. It really feels that way to me and i seem to have a high sensitivity to noradrenaline.
 
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