UnBounD
Bluelighter
upon snorting 5mg of valium I got no effect at all when 5mg the other day injested orally worked fine....why isnt there any effect when it is snorted
Originally posted by UnBounD:
it would make more sense though that a low does would have some effect snorted like if you rail a .5mg of xanex it hits you alot harder than if you would of ate it. so most likely valium isnt a polor substance and thats why it can't dissolve throught the nasal membrane
UTFSE! This question gets asked/discussed about every other day. Benzos are NOT water soluble. Snorthing them is a WASTE of time unless you follow them up with a snort of vodka... EAT THEM! If you *think* they hit you harder snorting them, you're fooling yourself- plain and simple. The only reason you feel anything by snorthing them is from the drip hitting your stomach.
doc
Originally posted by Dr.groveller:
Benzos are NOT water soluble.
According to Merck Index (12th ed.) diazepam is slightly soluble in water.
Originally posted by Drug Dustbin:
According to Merck Index (12th ed.) diazepam is slightly soluble in water.
Slightly! SLIGHTLY is damn close to NOT. Do your own experiment- crush them up and put them in water- watch what doesn't happen- this is the whole reason it's REAL tough to bang benzos.
Whatever
doc
Originally posted by Dr.groveller:
Slightly! SLIGHTLY is damn close to NOT. Do your own experiment- crush them up and put them in water- watch what doesn't happen- this is the whole reason it's REAL tough to bang benzos.
I know the solubility problem when using benzodiazepines intravenously. But how do you explain the case reports of intranasal abuse of alprazolam [1]? Also flunitrazepam, which is quite lipid-soluble benzodiazepine, reaches systemic
circulation 5 minutes after snorting [2].
[1] Sheehan MF, Sheehan DV, Torres A, Coppola A, Francis E.
Snorting benzodiazepines.
Am J Drug Alcohol Abuse. 1991;17(4):457-68.
[2] Bond A, Seijas D, Dawling S, Lader M.
Systemic absorption and abuse liability of snorted flunitrazepam.
Addiction. 1994 Jul;89(7):821-30.
Originally posted by HYDRO_CHRONIC:
enough already!!...EVER HEARD OF "PLACEBO"
Placebo can account some of the effects, but you can not deny the fact that flunitrazepam is detected in blood within five minutes after snorting. Flunitrazepam is insoluble in water and is slightly less lipid-soluble than diazepam.
Originally posted by dan0125:
While you can snort benzos like Valium, it's really not necessary. It doesn't get absorbed into your nasal membrane, like cocaine, or opiates. You still feel the effects, but you have to wait until it drips down the back of your throat and into your stomach. Anyway, 5mg is a very low dose of Valium, even for a first-timer. I'd try swallowing 20-30mg next time. If you want it to kick in faster try letting them dissolve under your tongue, which is called the sublingual method.
What is the point of administering a benzo sublingually if it cannot be absorbed intranasally? They work on the same principle, do they not?