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  • BDD Moderators: Keif’ Richards

Valium, Propranolol, Amitriptyline, Dexedrine - Stress, Study, Sleep

R

reflekt

Bluelighter
Joined
Feb 22, 2011
Messages
301
So... A bunch of shit just went down in the past several hours that left me infuriated and anxious.

To calm down I took 4 10mg Valiums (legitimate Roche). It's working psychologically. However, I was not satisfied with it physically...

So, I took 4x10mg Propranolol to slow down my tremor and heart racing.

I then took 7.5mg Dexedrine because I have a midterm I need to study for.

I plan on taking probably 4 more 5mg Dexedrine spaced out by 2 hours.

I also take Amitriptyline 25mg every night before bed, which I will be taking in 2-3 hours.

Along with that, I plan on taking another couple 10mg Valium to ease with sleeping after taking Dexedrine late at night.

This is quite the cocktail, I know... However, I am extremely comfortable with substance intake and have a tolerance to Valium.

Could this pose any major problems? Or should I switch up the times of doses?

Thanks!
 
I'm not 100% sure I understand the question, are you asking if you could do this combination on a daily basis or if there are any interactions between all the drugs listed?
 
Oh, sorry about that, anxiety must have got the best of me.

I was just wondering if it is safe to administrate the drugs in the way I described.

Or, if there is any interactions that would decrease the positive effects of some.

One time thing. Just tonight.
 
Well, the propranolol and Valium (diazepam) will probably completely counter-act the effects of the Dexedrine (dextroamphetamine)...

This resource says that mixing amitriptyline with dextroamphetamine could cause adverse reactions.

To be honest, it doesn't sound safe or effective...I would remove the propranolol and amitriptyline from the mix if you could....unless you need to take those medications.

Speaking as a person with panic disorder...amphetamines can cause some major anxiety...and I wouldn't recommend mixing amitriptyline and dextroamphetamine anyway.

Hopefully somebody with more experience with those drugs in question (I've never had propranolol or amitriptyline) can chime in :)
 
So despite the fact that diazepam doesn't effect dopamine, GABA would prevent dopamine's release? (I hope I worded that properly. I also hope you get what I mean lol)

Amitriptyline I do need daily for neuropathy. However, I can wait hours later to take it, as Valium should ease the nerve pain what with it having anti-convulsion properties and all. I have mixed the ami with d-amp before... Well... As a sleep aid afterward.

I have much experience with Dexedrine and haven't had many problems with respects to anxiety. So I'll hope for the best there.

Thanks a bunch for your reply though, really. I'll take it all into consideration now and into the future.
 
I would skip the amitriptaline for this evening (I personally despise the chemical, but that's personal preference - if it works, it works), and I think you'll be fine with the rest. Don't go too heavy with the beta blocker though (propranolol), or the valium due to its very long half-life (40-100 hours or something like that) for that matter.

The dexedrine will counter-act much of the sedation (probably until you're awake again and get some food in ya - which you're definitely going to want to do).

Good luck on your midterm! :)
 
Thanks a bunch, Pjkt2501!

I'll try and skip the amitriptyline this evening. Last time I missed the dose by 6 hours, I was in excruciating nerve pain for about 4 hours even after I took it (it's peak plasma is 3-4 hours after oral administration). Hopefully, as I said before, the Valium in my system will dull the pain! Haha.

Might I ask, though... For what reason do you recommend I skip the amitriptyline dose, exactly? Is it because the d-amp releases norepinephrine and the amitriptyline inhibits the reuptake... Resulting in too much norepinephrine, I assume? That makes sense...
 
It's because amitriptyline works similarly to DXM and PCP - it's an NDMA antagonist (agonist? I forget, whatever) and causes similar damage to the brain with extended use. I forget where I read this, will have to look around (just spent a few minutes looking before posting this and didn't find what I had last time - my gf's mum got an Rx for this and we got her off of it immediately.. she was also high as hell when she took it haha [maybe she just wasn't used to being happy..:(]).

Here's a different form of damage: http://www.ncbi.nlm.nih.gov/pubmed/21501668
 
Pjkt2501 said:
It's because amitriptyline works similarly to DXM and PCP - it's an NDMA antagonist (agonist? I forget, whatever) and causes similar damage to the brain with extended use. I forget where I read this, will have to look around (just spent a few minutes looking before posting this and didn't find what I had last time - my gf's mum got an Rx for this and we got her off of it immediately.. she was also high as hell when she took it haha [maybe she just wasn't used to being happy..:(]).

Here's a different form of damage: http://www.ncbi.nlm.nih.gov/pubmed/21501668
Click to expand...

She got high off of Elavil? Are you sure it wasn't just the initial sedation most TCA's herald in for the first few months?
 
Did not know it had NDMA-antagonist properties. Jesus. I have never taken amitriptyline, just nortriptyline and doxepin on a few occassions.
 
http://www.medaphile.com/medical-dictionary/ketamine-amitriptyline-np-h-cream

NDMA receptor antagonists such as amitriptyline and ketamine interfere with the role of NMDA receptors in the process of central sensitization in which NMDA receptors on spinal dorsal horn neurons are activated, resulting in an increase in synaptic efficacy and so an amplification of the response to sensory input.
Click to expand...

Yeah, I was rather pissed off when I was trying to buy 2x 30mg oxycodones and got 2 of these instead. They look almost identical, and have the same script on them (V). Ah well.

http://www.waterbcn2011.org/powerpo...7298_JULIEN_LEROUX/LeRoux_IWA_barcelona_2.pdf

Slide 8 even has some comparative data.
 
I'm on a low, possibly the lowest, dose of amitriptyline: 25mg/night. Some people who are prescribed it for depression take 75mg minimum lol. That's terrible.

I'm only on it for about a month anyway until I can get in for an EMG test at the end of the month.

I didn't take my dose last night, though, and I'm fine.

I have a lot of experience with DXM. I knew TCA's were NMDA antagonists, though, but with such a low dose for a short period of time I'm not worried.
 
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